Lisa E. Kratz, PhD
Highlights
Languages
- English
Gender
FemaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Lisa E. Kratz
Primary Academic Title
Associate Professor of Genetic Medicine
Background
Dr. Lisa Kratz is an assistant professor of pediatrics at the Johns Hopkins University School of Medicine. Her research focuses on inborn errors of metabolism.
She is also director of the Biochemical Genetics Laboratory at the Kennedy Krieger Institute.
Dr. Kratz received her undergraduate degree from Western Maryland College and her doctorate in human genetics from the University of Maryland at Baltimore. She completed a post-doctoral fellowship in biochemical genetics at the University of Colorado Health Sciences Center.
Prior to joining Johns Hopkins and the Kennedy Krieger Institute, Dr. Kratz was the assistant director of the biochemical diseases detection laboratory at Yale University.
Dr. Kratz is a member of the American Society of Human Genetics and the Society for Inherited Metabolic Disorders.
Centers and Institutes
Additional Academic Titles
Associate Professor of Pediatrics
Research Interests
Disorders of cholesterol biosynthesis including Smith-Lemli-Opitz syndrome, sesmosterolosis, x-linked dominant Conradi Hünermann syndrome and CHILD sequence, Disorders of creatine synthesis and transport, Barth syndrome, and mevalonate kinase deficiency, Inborn errors of metabolism
Research Summary
Dr. Kratz's research focuses on inborn errors of metabolism. One particular area of interest involves disorders of cholesterol biosynthesis including Smith-Lemli-Opitz syndrome, desmosterolosis, x-linked dominant Conradi Hünermann syndrome, and CHILD sequence. She is also interested in disorders of creatine synthesis and transport, Barth syndrome and mevalonate kinase deficiency.
Selected Publications
Dias C, Rupps R, Millar B, Choi K, Marra M, Demos M, Kratz LE, Boerkoel CF. “Desmosterolosis: an illustration of diagnostic ambiguity of cholesterol synthesis disorders.” Orphanet J Rare Dis. 2014 Jun 25;9:94. doi: 10.1186/1750-1172-9-94.
Gauthier N, Wu JW, Wang SP, Allard P, Mamer OA, Sweetman L, Moser AB, Kratz L, Alvarez F, Robitaille Y, Lépine F, Mitchell GA. “A liver-specific defect of Acyl-CoA degradation produces hyperammonemia, hypoglycemia and a distinct hepatic Acyl-CoA pattern.” PLoS One. 2013 Jul 5;8(7):e60581. doi: 10.1371/journal.pone.0060581. Print 2013.
Herman GE, Kratz L. “Disorders of sterol synthesis: beyond Smith-Lemli-Opitz syndrome.” Am J Med Genet C Semin Med Genet. 2012 Nov 15;160C(4):301-21. doi: 10.1002/ajmg.c.31340. Epub 2012 Oct 5.
Sparks SE, Wassif CA, Goodwin H, Conley SK, Lanham DC, Kratz LE, Hyland K, Gropman A, Tierney E, Porter FD. “Decreased cerebral spinal fluid neurotransmitter levels in Smith-Lemli-Opitz syndrome.” J Inherit Metab Dis. 2014 May;37(3):415-20. doi: 10.1007/s10545-013-9672-5. Epub 2014 Feb 6.
Sukhanova A, Gorin A, Serebriiskii IG, Gabitova L, Zheng H, Restifo D, Egleston BL, Cunningham D, Bagnyukova T, Liu H, Nikonova A, Adams GP, Zhou Y, Yang DH, Mehra R, Burtness B, Cai KQ, Klein-Szanto A, Kratz LE, Kelley RI, Weiner LM, Herman GE, Golemis EA, Astsaturov I. “Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.” Cancer Discov. 2013 Jan;3(1):96-111. doi: 10.1158/2159-8290.CD-12-0031. Epub 2012 Nov 2.
Memberships
- American Society of Human Genetics
- Society for Inherited Metabolic Disorders
Additional Training
Education
Ph.D.
University of Maryland at Baltimore
1989
Human Genetics
Baltimore, MD
B.A.
Western Maryland College
1985
Westminster, MD
Training
Fellowships
University of Colorado Health Sciences Center
1991
Biochemical Genetics
Certification
Biochemical Genetics, 1993
Locations
- 707 North Broadway, Kennedy Krieger Institute, Baltimore, MD 21205
- phone: 443-923-2782
- fax: 443-923-2781