
Khaled Mahmoud El-Shami, MBCHB, MS, PhD
Leukemia
Lymphoma
Hematologic Malignancy
Highlights
Johns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Khaled Mahmoud El-Shami
Primary Academic Title
Assistant Professor of Oncology
Background
Khaled M. El-Shami, M.B.Ch.B., Ph.D., is a medical oncologist at Johns Hopkins Kimmel Cancer Center at Sibley Memorial Hospital, as well as an assistant professor of oncology in the Division of Hematologic Malignancies at Johns Hopkins University School of Medicine.
Listen to Dr. El-Shami's Cancer Matters podcast episode to learn more about his work.
Dr. El-Shami's clinical interests are in hematologic malignancies, including leukemias, lymphomas and myelomas..
Dr. El-Shami graduated from Alexandria University Faculty of Medicine in Alexandria, Egypt, where he did a residency in the Department of Neurosurgery. He was a Chevening Scholar as a M.S. student in molecular genetics at the University of Sussex in the United Kingdom, as well as a Sam Cohen Windhoek Scholar as a Ph.D. student in cancer immunology at the Weizmann Institute in Israel. Dr. El-Shami also completed a residency in internal medicine at George Washington University School of Medicine, a fellowship in tumor immunology and biology at the National Cancer Institute, and a fellowship in medical oncology at Johns Hopkins University School of Medicine. Dr. El-Shami previously served as faculty at Georgetown University and George Washington University.
Dr. El-Shami has been named a Top Doctor by Washingtonian Magazine for several years.
Dr. El-Shami is a member of the American Association for Advancement of Science, the American Association of Cancer Research, the American Association of Immunologists, the American Society for Gene Therapy and the American Society of Clinical Oncology.
Dr. El-Shami's research focus is on hematologic malignancies, including acute and chronic leukemias, myelodysplastic syndromes, myeloprolifetive neplasms and lymphomas. He has received the National Institutes of Health Clinical Research Scholars Award, an American Medical Association Seed Grant and an American Society of Clinical Oncology Merit Award.
Centers and Institutes
Recent News Articles and Media Coverage
Cancer Matters Podcast: Dr. Bill Nelson discussing the treatment of leukemia and the growing hematologic program at Sibley, Johns Hopkins Kimmel Cancer Center Podcasts (January 24, 2019)
Research Interests
Lymphomas, Acute Leukemias, Chronic Leukemias, Drug Development in lymphoid Malignancies, Hematologic Malignancies.
Selected Publications
El-Shami, K., Oeffinger, K.C., Erb, N.L., Willis, A., Bretsch, J.K., Pratt-Chapman, M.L., Cannady, R.S., Wong, S.L., Rose, J., Barbour, A.L., Stein, K.D., Sharpe, K.B., Brooks, D.D., Cowens-Alvarado, R.L. "American Cancer Society Colorectal Cancer Survivorship Care Guidelines." CA Cancer J Clin. 2015 Nov-Dec;65(6):428-55. doi: 10.3322/caac.21286. Epub 2015 Sep 8. Review.
El-Shami, K., Stone, R.M., Smith, B.D. "FLT3 inhibitors in acute myeloid leukemia." Expert Rev Hematol. 2008 Dec;1(2):153-60. doi: 10.1586/17474086.1.2.153. Review.
Hossain, A., Rafei, H., Jariwala, A., El-Shami, K. "A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia." Leuk Res Rep. 2017 Jan 24;7:20-22. doi: 10.1016/j.lrr.2017.01.001. eCollection 2017.
Parikh, S.A., Kantarjian, H., Schimmer, A., Walsh, W., Asatiani, E., El-Shami, K., Winton, E., Verstovsek, S. "Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis." Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9. doi: 10.3816/CLML.2010.n.059.
Zheng, L., Edil, B.H., Soares, K.C., El-Shami, K., Uram, J.N., Judkins, C., Zhang, Z., Onners, B., Laheru, D., Pardoll, D., Jaffee, E.M., Schulick, R.D. "A safety and feasibility study of an allogeneic colon cancer cell vaccine administered with a granulocyte-macrophage colony stimulating factor-producing bystander cell line in patients with metastatic colorectal cancer." Ann Surg Oncol. 2014 Nov;21(12):3931-7. doi: 10.1245/s10434-014-3844-x. Epub 2014 Jun 19.
Honors
- Top Doctor, Washingtonian Magazine
- Merit Award, American Society of Clinical Oncology
- Attending of the Year Award, George Washington University School of Medicine
- Clinical Research Scholars Award, National Institutes of Health
Memberships
- American Association for Advancement of Science,
Member
- American Association of Cancer Research,
Member
- American Association of Immunologists,
Member
- American Society for Gene Therapy,
Member
- American Society of Clinical Oncology,
Member
Locations
- Sibley Memorial Hospital
- 5255 Loughboro Road Northwest, Building B, Washington, DC 20016
- phone: 202-660-6500
- fax: 202-660-6501
Expertise
Education
Johns Hopkins University School of Medicine
Fellowship, Oncology, 2008The George Washington University School of Medicine
Residency, Internal Medicine, 2005Weizmann Institute Weinberg Graduate School
Graduate School, PhD, 2000University of Sussex
Graduate School, BioChemistry, MS, 1993Alexandria University Hospital
Residency, Surgery, 1992Alexandria University Faculty of Medicine
Medical Education, MBChB MS, 1987Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)
Ratings & Reviews
5 out of 5
230 ratings, 92 reviewsThe Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
- 5 out of 5 starsReviewed on 3/19/2025
Excellent
- 5 out of 5 starsReviewed on 2/17/2025
Dr. El-Shami is the finest doctor I've ever been treated by.
- 5 out of 5 starsReviewed on 2/14/2025
Dr. El-Shami is an outstanding specialist.I am very fortunate to be his patient.
- 5 out of 5 starsReviewed on 2/12/2025
He is very knowledgeable and is able to translate his knowledge to my specific case
- 5 out of 5 starsReviewed on 2/10/2025
I am very pleased with this doctor. He take his time to hear my concern and provides answer. An excellent doctor he does rush to get you out of his office.
- 5 out of 5 starsReviewed on 2/10/2025
Dr El-Shami is kind, thoughtful, friendly, concerned and excellent.
- 5 out of 5 starsReviewed on 2/7/2025
Excellent
- 5 out of 5 starsReviewed on 2/7/2025
Dr. El-Shami Is a superb provider. I was impressed with his understanding of my current and former health history. He met my expectations and more, which were quite high for that visit. I felt he was open minded and tuned into some of my questions and concerns. He instilled a sense of confidence of guiding me firmly, but with consideration of who I am as a person.
- 5 out of 5 starsReviewed on 2/5/2025
Excellent care
- 5 out of 5 starsReviewed on 2/3/2025
Very,very good
- 5 out of 5 starsReviewed on 1/31/2025
The best! Very knowledgeable and empathetic
- 5 out of 5 starsReviewed on 1/29/2025
A very competent doctor.
- 5 out of 5 starsReviewed on 1/24/2025
The medical oncology center at Sibley is just fantastic. So is Dr. El-Shami.
- 5 out of 5 starsReviewed on 1/15/2025
Dr. El-Shami is the best! My life is in his hands and I trust him implicitly.
- 5 out of 5 starsReviewed on 1/15/2025
Frienclly, helpful
- 5 out of 5 starsReviewed on 1/15/2025
Dr El-Shami is excellent. He makes me feel very comfortable when discussing my health. 5 stars plus
- 5 out of 5 starsReviewed on 1/13/2025
Dr. El-Shami is both brilliant and compassionate. I trust him implicitly with my care.
- 5 out of 5 starsReviewed on 1/10/2025
I am confident re the care and advice provided to me by Dr. El-Shami.
- 5 out of 5 starsReviewed on 12/30/2024
A+
- 5 out of 5 starsReviewed on 12/23/2024
Good
- 5 out of 5 starsReviewed on 12/20/2024
He's terrific: explains what the health issue is, how I am-health wise-, anything I should or shouldn't do. He is patient, helpful, and knowledgeable.
- 5 out of 5 starsReviewed on 12/20/2024
I appreciate my provider El his patience and willing to listen
- 5 out of 5 starsReviewed on 12/16/2024
Very knowledgeable and experienced and very friendly and caring about the patient.
- 5 out of 5 starsReviewed on 12/13/2024
Dr is really excellent
- 5 out of 5 starsReviewed on 12/9/2024
As long as I am benefiting from their service and they continue to be professional I will continue to use them
- 5 out of 5 starsReviewed on 12/6/2024
Very trustworthy, kind, thorough
- 5 out of 5 starsReviewed on 12/6/2024
There are no words to thank - [staff] and Dr. El-Shami For their expertise care and guidance through my journey of non-Hodgkin's lymphoma.
- 5 out of 5 starsReviewed on 12/2/2024
Dr El-Shami helped me understand about my illness and made me feel very confident about the treatment.
- 5 out of 5 starsReviewed on 11/27/2024
Extremely attentive to my somewhat unusual situation and plan of action to manage my cancer.
- 5 out of 5 starsReviewed on 11/22/2024
Exceptional compassion, warmth & care.
- 5 out of 5 starsReviewed on 11/18/2024
Dr. El-Shami always makes sure I understand exactly what he says.
- 5 out of 5 starsReviewed on 11/14/2024
Dr El-Shami asked, listened and showed care about my current situation.
- 5 out of 5 starsReviewed on 11/13/2024
Dr. El-Shami is an excellent doctor. Not only is he very knowledgeable, he also has a awesome bedside manner. He is very thoughtful, kind and concerned about me having the best of care.
- 5 out of 5 starsReviewed on 11/8/2024
Dr. El Shami is an excellent and caring physician.
- 5 out of 5 starsReviewed on 11/6/2024
Amazing Dr. El- Shami!!!
- 5 out of 5 starsReviewed on 11/4/2024
Dr. El-Shami is unformly excellent in his care and attention to my medical issues.
- 5 out of 5 starsReviewed on 11/1/2024
Always very informative and supportive related to my condition and related test results
- 5 out of 5 starsReviewed on 11/1/2024
Dr. El-Shami is the best. He saved my life.
- 5 out of 5 starsReviewed on 10/28/2024
Dr el-shami is a treasure. A fantastic doctor and a great person.
- 5 out of 5 starsReviewed on 10/28/2024
Very courteous and understanding
- 5 out of 5 starsReviewed on 10/25/2024
Dr. El-Shami is an excellent Dr. With a tremendous knowledge in his field.
- 5 out of 5 starsReviewed on 10/25/2024
Outstanding
- 5 out of 5 starsReviewed on 10/25/2024
Dr El Shami is kind, listens attentively, makes excellent eye contact, thoughtful and reassuring.
- 5 out of 5 starsReviewed on 10/2/2024
Excellent
- 5 out of 5 starsReviewed on 10/2/2024
Very knowledgeable and was easy to communicate with
- 5 out of 5 starsReviewed on 9/30/2024
Great
- 5 out of 5 starsReviewed on 9/25/2024
Dr. El-Shami is the best
- 5 out of 5 starsReviewed on 9/18/2024
During my ongoing period of care via Dr. El Shami, I feel confident that I have received good care.
- 5 out of 5 starsReviewed on 9/16/2024
Superb physician an excellent clinician & a very humane wonderful person the best I have ever met in my life.
- 5 out of 5 starsReviewed on 9/16/2024
He was very understanding and informative about my condition. He made me feel that I was in good hands.
- 5 out of 5 starsReviewed on 9/11/2024
Super doc who listens
- 5 out of 5 starsReviewed on 9/9/2024
Outstanding. He cares and is very interested in.my continued recovery from the lymphoma he treated me for.
- 5 out of 5 starsReviewed on 9/9/2024
Dr ElShami is outstanding, very kind and makes me feel safe
- 5 out of 5 starsReviewed on 8/30/2024
Excellent and knowledgeable professional. Answered all questions precisely. Totally explained my situation and procedure going forward
- 5 out of 5 starsReviewed on 8/28/2024
Dr El Shami has been caring for me for 10 years and is absolutely the best
- 5 out of 5 starsReviewed on 8/26/2024
Dr El-Shami has always listened to my concerns and has answered them to my satisfaction and understanding
- 5 out of 5 starsReviewed on 8/26/2024
Very good support
- 5 out of 5 starsReviewed on 8/19/2024
Dr El-Shami is a #1 physician, caring, listening, providing information.
- 5 out of 5 starsReviewed on 8/16/2024
Excellent provider
- 5 out of 5 starsReviewed on 8/16/2024
He's great; knowledgeable, patient, understanding, thorough.
- 5 out of 5 starsReviewed on 8/9/2024
Dr. El-Shami is very knowledgeable and caring. He takes all the time required to listen and answer any questions.
- 5 out of 5 starsReviewed on 7/29/2024
Extremely knowledgeable and caring. Saved my life--probably twice!
- 5 out of 5 starsReviewed on 7/22/2024
Dr. El Shami displayed a thorough understanding of my condition, provided in depth explanations of the treatment options, and helped me make a we informed decision. He presents as knowledgeable, compassionate, caring and unhurried. I would definitely seek his advice again and would wholeheartedly recommend him.
- 5 out of 5 starsReviewed on 7/19/2024
Provider allowed us time to discuss [Patient] results and further treatment
- 5 out of 5 starsReviewed on 7/17/2024
Dr. El-Shami has been fabulous. I feel like I am getting the best possible care for my condition.
- 5 out of 5 starsReviewed on 7/17/2024
Thorough, knowledgeable, conscientious, polite and caring. I am fortunate to have him caring for me
- 5 out of 5 starsReviewed on 6/28/2024
EXCELLENT!
- 5 out of 5 starsReviewed on 6/26/2024
Consistently excellent care
- 5 out of 5 starsReviewed on 6/26/2024
Dr. El Shami is the best doctor I have ever had and I've had many.
- 5 out of 5 starsReviewed on 6/26/2024
Dr El Shami is always attentive and professional. He spends time explaining test results and therapies. I feel like I'm in good hands.
- 5 out of 5 starsReviewed on 6/26/2024
Dr El-Shami is extremely smart and focused on his patient.
- 5 out of 5 starsReviewed on 6/24/2024
Excellent. Could not be bettrer.
- 5 out of 5 starsReviewed on 6/7/2024
Terrific Dr.
- 5 out of 5 starsReviewed on 5/29/2024
Doctor El-Shami was great, in terms of being very professional and knew the reason I was there. He clearly explained everything to me and made sure I understood.
- 5 out of 5 starsReviewed on 5/24/2024
Highly pleased
- 5 out of 5 starsReviewed on 5/24/2024
I'm thankful to God Almighty for the doctor El Sharmi is very understanding and very patient and he sit and talk to me and treated me with respect and making sure that I understood what he was telling me about my health I'm grateful
- 5 out of 5 starsReviewed on 5/22/2024
Dr El-Shami is the best!!!!!
- 5 out of 5 starsReviewed on 5/21/2024
Very knowledgeable about my disease and condition. Excellent about reviewing my overall health.
- 5 out of 5 starsReviewed on 5/20/2024
Dr. Elshami is professional, compassionate, knowledgeable, and effectively saved my life recommending Car tea therapy
- 5 out of 5 starsReviewed on 5/15/2024
He is very attentive and compassionate. I felt that he had put in the time familiarizing himself with my medical history before our appointment.
- 5 out of 5 starsReviewed on 5/15/2024
Dr. El-Shami is the most professional, warn, compassionate & caring doctor. He listens & makes me feel very comfortable & confident with my treatments.
- 5 out of 5 starsReviewed on 5/15/2024
Dr. El-Shami is great. He explains every issue that comes up in understandable detail. He took the time to explain something that is tangential to the condition I see him about, as well as details of other medical issues with which I deal.
- 5 out of 5 starsReviewed on 5/15/2024
Compassionate caring and informative Dr. He sees my mind at ease and takes time to explain everything
- 5 out of 5 starsReviewed on 5/10/2024
Doctor Khalid El- Shami
- 5 out of 5 starsReviewed on 5/8/2024
He's the best oncologist in DC! He's keeping me alive! I'd follow him anywhere!
- 5 out of 5 starsReviewed on 5/8/2024
Great working with Dr. El Shami
- 5 out of 5 starsReviewed on 4/23/2024
The doctor has been has been diligent in my healing process. I feel as though he genuinely cares about my health in getting rid of this cancer.
- 5 out of 5 starsReviewed on 4/22/2024
It was actually my first visit with Dr. El-Shahimi, though I've seen other providers in this office for several years. He was truly excellent.
- 5 out of 5 starsReviewed on 4/19/2024
Dr El-Shami is in absolutely the best Dr. Very much the expert with a great bedside manner.
- 5 out of 5 starsReviewed on 4/16/2024
Superb ! Excellent! Compassionate & Caring one of the very BEST physicians I have ever encountered in my own life as a physician of 37 years experience .
- 5 out of 5 starsReviewed on 4/3/2024
Dr. El Shami is excellent, kind, careful, caring and explains clearly what's going on and how to handle it
- 5 out of 5 starsReviewed on 4/2/2024
Very good