Danny Muehlschlegel, MD, MBA, MSC
Anesthesiology
- Johns Hopkins School of Medicine Faculty
About Danny Muehlschlegel
Professional Titles
- Chair, Department of Anesthesiology and Critical Care Medicine
- Mark C. Rogers Chair in Anesthesiology and Critical Care Medicine
Primary Academic Title
Professor of Anesthesiology and Critical Care Medicine
Background
J. Danny Muehlschlegel, MD, MMSc, MBA, FAHA, FASA is an attending cardiovascular anesthesiologist at Johns Hopkins University School of Medicine, where he serves as the Director (Chair) of the Department of Anesthesiology and Critical Care Medicine. He is also a Professor of Anesthesiology and Critical Care Medicine at the Johns Hopkins School of Medicine and the Mark C. Rogers Professor.
As a cardiac anesthesiologist with significant subspecialty training in all aspects of cardiac disease and transesophageal echocardiography, Dr. Muehlschlegel is a perioperative physician guiding the care of very sick patients with cardiovascular disease.
Dr. Muehlschlegel is an NIH-funded physician-scientist with an active laboratory examining the impact of genetic variation upon adverse cardiovascular events and their significance on a functional level. He is the principal investigator of the CABG Genomics study group and the PI of the NHLBI-sponsored TRANSCRIBE (transcriptomic analysis of left ventricular gene expression) study. Both studies aim to determine the relationship between genetic variation and perioperative myocardial injury in patients undergoing cardiac surgery. Dr. Muehlschlegel is also the principal investigator of the NHLBI-sponsored GENEXPRO Surg (Gene Expression Profiling in Subjects with Postoperative Atrial Fibrillation after Cardiac Surgery) which aims to characterize the left atrium, the site in proximity to the origination of atrial fibrillation, using a multi ‘omics approach.
Among his leadership roles, Muehlschlegel serves on the Board of Directors of the Society of Cardiovascular Anesthesiologists and is a member of the Association of University Anesthesiologists, the Association of Cardiac Anesthesiologists, and on the leadership committee of the American Heart Association’s Council on Cardiovascular Surgery and Anesthesia. He is also an associate oral board examiner of the American Board of Anesthesiology, which will allow him to contribute to, and have a national impact on the specialty of anesthesiology.
Research Summary
My research investigates the impact of genetic variation on adverse cardiovascular events and their functional significance. My cardiac anesthesia patients, possessing transcriptional upregulation, serve as research subjects, enabling genetic transcription variation analysis. I spearhead the CABG Genomics and TRANSCRIBE study groups, focusing on genetic variation's role in perioperative myocardial injury during cardiac surgery. I also manage the GENEXPRO Surg project, utilizing multi 'omics approaches to understand postoperative atrial fibrillation. As Chief Scientific Officer for Team Heart, I blend clinical cardiac anesthesia with genetic research, examining the genetics behind rheumatic heart disease in Rwanda through the RECHARGE study.
Selected Publications
Kelly BJ, Ho Luxford JM, Butler CG, Huang CC, Wilusz K, Ejiofor JI, Rawn JD, Fox JA, Shernan SK, Muehlschlegel JD. Severity of tricuspid regurgitation is associated with long-term mortality. J Thorac Cardiovasc Surg. 2018 Mar;155(3):1032-11038.e2. PMID: 29246545, PMCID: PMC5819734
Saddic LA, Nicoloro SM, Gupta OT, Czech MP, Gorham J, Shernan SK, Seidman CE, Seidman JG, Aranki SF, Body SC, Fitzgibbons TP, Muehlschlegel JD. Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia. Cardiovasc Diabetol. 2017 Jul 7;16(1):87. PMID: 28687077, PMCID
Stone G, Choi A, Meritxell O, Gorham J, Heydarpour M, Seidman CE, Seidman JG, Aranki SF, Body SC, Carey VJ, Raby BA, Stranger BE, Muehlschlegel JD. Sex differences in gene expression in response to ischemia in the human left ventricular myocardium. Hum Mol Genet. 2019 May 15;28(10):1682-1693. PMID: 30649309, PMCID: PMC6494791
Ward Z, Schmeier S, Saddic L, Sigurdsson MI, Cameron VA, Pearson J, Miller A, Morley-Bunker A, Gorham J, Seidman JG, Moravec CS, Sweet WE, Aranki SF, Body S, Muehlschlegel JD*, Pilbrow AP*. Novel and Annotated Long Noncoding RNAs Associated with Ischemia in the Human Heart. Int J Mol Sci. 2021 Oct 20;22(21). PMID: 34768754, PMCID: PMC8583240. Joint senior author.
Wollborn J, Karamnov S, Fields KG, Yeh T, Muehlschlegel JD. COVID-19 increases the risk for the onset of atrial fibrillation in hospitalized patients. Sci Rep. 2022 Jul 14;12(1):12014. PMID: 35835807, PMCID: PMC9281233
Honors
- Excellence in Mentoring Award, Women in Cardiothoracic Anesthesia, 1/1/23
- Kaplan Leadership Development Award, Society of Cardiovascular Anesthesiologists, 1/1/19
- Distinguished Chair in Anesthesiology, Brigham and Women's Hospital, 1/1/18
- Distinction in Mentoring Award, Department of Anesthesiology, Perioperative and Pain Medicine, 1/1/17
Locations
- The Johns Hopkins Hospital
- 1800 Orleans Street, Baltimore, MD 21287
- phone: 410-955-5000
- fax: 410-955-5001
Expertise
Education
Massachusetts Institute of Technology
Graduate School, MBA, 2021Harvard Medical School
Graduate School, MMSc, 2010Brigham and Women's Hospital
Fellowship, Cardiac Anesthesiology, 2008UF Health Shands Hospital
Residency, Anesthesiology, 2006Albert-Ludwigs Universitaet Freiburg
Medical Education, MD, 2001Board Certifications
Adult Cardiac Anesthesiology
American Board of Anesthesiology, 2023Anesthesiology
American Board of Anesthesiology, 2007Advanced Perioperative Transesophageal Echocardiography
National Board of Echocardiography, 2007Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)