Jinchong Xu, MED, PhD, M

Professional Titles

• Director, Human iPS Cell Core for Neurodegenerative Disease Research, Johns Hopkins Alzheimer's Disease Research Center

Primary Academic Title

Assistant Professor of Neurology

Background

Recent News Articles and Media Coverage

• Experts to Study Human Tissue Models' Responses to Space Radiation, And Develop Countermeasures, Johns Hopkins Institute For Nanobiotechnology (October 2, 2020)

Contact for Research Inquiries

733 N. Broadway
Miller Research Building, MRB 769
Baltimore, MD 21205-1832

Phone: (410) 614-6124

Research Interests

Neuroinflammation, Neurological Disorders, Stem Cells

Lab Website

Jinchong Xu - Lab Website

Research Summary

Dr. Xu conducts basic and translational research aimed at better understanding the roles of neural activity dependent surviving pathways in early pathogenesis of Alzheimer’s disease (AD) and inflammatory regulation in a variety of neurodegenerative disease, in which we utilize a large panel of isogenic human induced pluripotent stem cell (iPS)-derived neural cells, preclinical mouse models and state-of-the-art techniques to understand the underlying mechanisms with the goal of developing new medical interventions.

Selected Publications

• Xu, J.-C., Bernreuther, C., Cui, Y.-F., Jakovcevski, I., Hargus, G., Xiao, M.-F., Schachner, M. “Transplanted L1 expressing radial glia and astrocytes enhance recovery after spinal cord injury.” (2011) Journal of Neurotrauma, 28 (9), pp. 1921-1937.

• Xu, J.-C., Dawson, V.L., Dawson, T.M. “Usp16 Key controller of stem cells in down syndrome.” (2013) EMBO Journal, 32 (21), pp. 2788-2789. PMCID: PMC3817468

• Xu, J.-C., Fan, J., Wang, X., Eacker, S.M., Kam, T.-I., Chen, L., Yin, X., Zhu, J., Chi, Z., Jiang, H., Chen, R., Dawson, T.M., Dawson, V.L. “Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity.” (2016) Science Translational Medicine, 8 (333), art. no. ra48. PMCID: PMC5595216.

• Xu, J.-C., Xiao, M.-F., Jakovcevski, I., Sivukhina, E., Hargus, G., Cui, Y.-F., Irintchev, A., Schachner, M., Bernreuther, C. “The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice.” (2014) Journal of Cell Science, 127 (3), pp. 641-652. PMID: 24338367. DOI: 10.1242/jcs.137612.

• Yin, X*, Xu, J.-C.*, Cho, G-S., Kwon, C., Dawson, T.M., Dawson, V.L. “Neurons derived from human inducible pluripotent stem cells integrate into rat brain circuits and maintain both excitatory and inhibitory synaptic activities.” (2019) eNeuro. 6(4). PMCID: PMC6709226. (*equal contribution, article highlighted on eNeuro.org homepage).

Honors

• Johns Hopkins Alzheimer's Disease Research Center Development Award, Johns Hopkins Alzheimer's Disease Research Center, 10/1/21
• Developmental Core Pilot Awards, NIMH Center for Novel Therapeutics, 7/1/21
• CFAR Scholar Award for Faculty Development, Center for AIDS Research, 7/1/20
• Stem Cell Research Fellowship Award, Maryland Stem Cell Research Fund, 6/30/16

Memberships

• Stroke Council, American Heart Association
• Professional Member, American Heart Association
• International Society for Stem Cell Research