Jennifer Foulke-Abel, PhD
Highlights
Languages
- English
Gender
FemaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Jennifer Foulke-Abel
Primary Academic Title
Assistant Professor of Medicine
Background
Dr. Jennifer Foulke-Abel is an Assistant Professor of Medicine in the Division of Gastroenterology & Hepatology at the Johns Hopkins University School of Medicine. Her research focuses on infectious diarrheal diseases and adult stem cell-based models of wound repair.
Dr. Foulke-Abel received her undergraduate degree and her Ph.D. in Biological Chemistry from Texas A&M University and completed her postdoctoral research training fellowship in Gastroenterology at Johns Hopkins University School of Medicine prior to joining the faculty.
Contact for Research Inquiries
720 Rutland Ave
Ross 929
Baltimore, MD 21205
Research Interests
Epithelial Wound Healing, Host-pathogen Interactions, Intestinal Organoids/enteroids, Intestinal Stem cells
Lab Website
Jennifer Foulke-Abel Lab
- The Jennifer Foulke-Abel Lab performs basic and translational research on Infectious Diarrheal Diseases.
Research Summary
Dr. Foulke-Abel’s research focuses in part on identifying preventatives and therapies to treat infectious diarrheal diseases such as cholera and E. coli. Her work utilizes intestinal organoids her team has established from adult intestinal stem cells to recapitulate all of the segments of the human gut.
Dr. Foulke-Abel is also engaged in studies to understand and optimize epithelial wound healing using the intestinal organoid model.
Selected Publications
Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz M. Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Exp Biol Med (Maywood) 2014 Sep;239(9):1124-34. doi: 10.1177/1535370214529398.
Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M. Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology. 2016 Mar;150(3):638-649.e8. doi: 10.1053/j.gastro.2015.11.047.
Foulke-Abel J, Yu H, Sunuwar L, Lin R, Fleckenstein JM, Kaper JB, Donowitz M. Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection. Gut Microbes. 2020 Nov 9;12(1):1752125. doi: 10.1080/19490976.2020.1752125.
In JG, Foulke-Abel J, Clarke E, Kovbasnjuk O. Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium. J Vis Exp. 2019 Apr 9;(146):10.3791/59357. doi: 10.3791/59357.
Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz M. Human enteroids/colonoids and intestinal organoids functionally recapitulate normal intestinal physiology and pathophysiology. J Biol Chem. 2016 Feb 19;291(8):3759–66. doi: 10.1074/jbc.R114.635995. PMID: 26677228.
Memberships
- American Gastroenterological Association
- American Physiological Society