![Hilary J. Vernon](https://cdn-images.kyruus.com/providermatch/johnshopkins/photos/orig/vernon-hilary-1245380047.jpg)
Hilary J. Vernon, MD, PhD
Clinical Biochemical Genetics
Medical Genetics
- Johns Hopkins School of Medicine Faculty
About Hilary J. Vernon
Primary Academic Title
Professor of Genetic Medicine
Background
Dr. Hilary Vernon is a Professor of Genetic Medicine and pediatrics at the Johns Hopkins University School of Medicine. She is also an attending physician at Kennedy Krieger Institute.
Hilary Vernon has expertise in treating inborn errors of metabolism and mitochondrial disorders. She is the director of the Mitochondrial Care Center at The Johns Hopkins Hospital and the Barth Syndrome Interdisciplinary Clinic at the Kennedy Krieger Institute. Her research interests include understanding intermediary metabolism in Barth syndrome and in disorders of branch chain amino acid metabolism. Dr. Vernon also co-directs the Department of Genetic Medicine Clinical Trials Unit, and is the principal investigator on multiple clinical trials for rare diseases.
Dr. Vernon received her medical degree and doctorate from Rutgers University, New Brunswick, New Jersey. She completed residencies in genetics and pediatrics at The Johns Hopkins University, and a fellowship in clinical laboratory biochemical genetics at The Johns Hopkins University.
Dr. Vernon was recognized with the 2010 Francis F. Schwentker Award for Excellence in Research at Johns Hopkins University and the 2011 James B. Sidbury Jr. Fellowship in Biochemical Genetics at Johns Hopkins University.
Centers and Institutes
Clinical Trials Summary
NCT03098797 A Trial to Evaluate Safety, Tolerability and Efficacy of Elamipretide in Subjects With Barth Syndrome
Additional Academic Titles
Professor of Pediatrics
Contact for Research Inquiries
733 North Broadway
MRB 529
Baltimore, MD 21036
Research Interests
Clinical laboratory biochemical diagnosis, Molecular and metabolic pathogenesis of Barth Syndrome, Molecular and metabolic pathogenesis of organic acidemias
Lab Website
The Vernon Lab for Translational Mitochondrial Medicine - Lab Website
- Dr. Vernon's Laboratory at the Department of Genetic Medicine develops and studies cellular models of mitochondrial disorders to understand their biological basis and to find new targets for therapeutic intervention.
Research Summary
Dr. Vernon's current area of study is in inborn errors of metabolism, which cause disturbances of mitochondrial function, including several different organic acidemias and Barth Syndrome. These are rare disorders, each with an approximate incidence of 1/50,000 - 1/250,000. They have an onset in childhood and a devastating effect on health and quality of life.
Dr. Vernon's lab uses a mass spectrometry-based metabolomics approach to create metabolic profiles of these disorders and select promising analytes from these profiles as potential treatment targets for further study. She is also using cell culture and animal-based models in identifying molecular and metabolic markers.
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/?term=Vernon%20HJ%5BAuthor%5D&cauthor=true&cauthor_uid=25851414
Selected Publications
Vernon H, Cohen J, De Nittis P, Fatemi A, McClellan R, Goldstein A, Malerba N, Guex N, Reymond A, Merla G. Intellectual developmental disorder with cardiac arrhythmia syndrome in a child with compound heterozygous GNB5 variants. Clin Genet. 2018 Jun;93(6):1254-1256.
Vernon HJ, Sandlers Y, McClellan R, Kelley RI. Clinical laboratory studies in Barth Syndrome. Mol Genet Metab. 2014 Jun;112(2):143-7
Ferreira CR, Goorden SMI, Soldatos A, Byers HM, Ghauharali-van der Vlugt JMM, Beers-Stet FS, Groden C, van Karnebeek CD, Gahl WA, Vaz FM, Jiang X, Vernon HJ. Deoxysphingolipid precursors indicate abnormal sphingolipid metabolism in individuals with primary and secondary disturbances of serine availability. Mol Genet Metab. 2018 Jul;124(3):204-209.
Sandlers Y, Mercier K, Pathmasiri W, Carlson J, McRitchie S, Sumner S, Vernon HJ. Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function. PLoS One. 2016 Mar 25;11(3):e0151802
Thompson WR, DeCroes B, McClellan R, Rubens J, Vaz FM, Kristaponis K, Avramopoulos D, Vernon HJ. New targets for monitoring and therapy in Barth syndrome. Genet Med. 2016 Oct;18(10):1001-10.
Honors
- James B. Sidbury, Jr. Fellowship in Biochemical Genetics, Johns Hopkins University, 1/1/11
- Francis F. Schwentker Award for Excellence in Research, Johns Hopkins University, 1/1/10
- Chief resident of medical genetics, Institute of Genetic Medicine, Johns Hopkins University, 1/1/10
- Margaret Nielsen Fellowship in Genetic Medicine, Johns Hopkins Institute of Genetic Medicine, 1/1/07
Memberships
- Diplomate, American Board of Pediatrics
- Member, The American Society for Human Genetics
Locations
- Rubenstein Child Health Building
- 200 North Wolfe Street, Rubenstein BLDG Lower Level, Baltimore, MD 21287
- phone: 443-287-9494
- fax: 410-367-3231
Expertise
Education
Johns Hopkins University School of Medicine
Fellowship, Biochemical Genetics, 2011Johns Hopkins University School of Medicine
Residency, Pediatric Genetics, 2010Rutgers Robert Wood Johnson Medical School
Medical Education, MD, 2004Rutgers The State University of New Jersey
Graduate School, Molecular Genetics, PhD, 2004Board Certifications
Clinical Genetics (MD)
American Board of Medical Genetics and Genomics, 2022Clinical Biochemical Genetics
American Board of Medical Genetics and Genomics, 2011Pediatrics
American Board of Pediatrics, 2009Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)