Henry R. Halperin, MD

Professional Titles

• David J. Carver Professor in Medicine
• Co-Director, Johns Hopkins Imaging Institute of Excellence
• Director, Advanced Cardiovascular Life Support

Primary Academic Title

Professor of Medicine

Background

Centers and Institutes

• Electrophysiology and Arrhythmia Service
• Heart and Vascular Institute
• Imaging Institute of Excellence

Additional Academic Titles

Professor of Biomedical Engineering, Professor of Radiology and Radiological Science

Research Interests

Cardiopulmonary Resuscitation, Computed Tomography, Image Guided Electrophysiology Intervention, Magnetic Resonance Imaging, Sudden Death

Lab Website

Cardiology Bioengineering Laboratory - Lab Website

• The Cardiology Bioengineering Laboratory, located in the Johns Hopkins Hospital, focuses on the applications of advanced imaging techniques for arrhythmia management. The primary limitation of current fluoroscopy-guided techniques for ablation of cardiac arrhythmia is the inability to visualize soft tissues and 3-dimensional anatomic relationships. Implementation of alternative advanced modalities has the potential to improve complex ablation procedures by guiding catheter placement, visualizing abnormal scar tissue, reducing procedural time devoted to mapping, and eliminating patient and operator exposure to radiation. Active projects include - Physiological differences between isolated hearts in ventricular fibrillation and pulseless electrical activity - Successful ablation sites in ischemic ventricular tachycardia in a porcine model and the correlation to magnetic resonance imaging (MRI) - MRI-guided radiofrequency ablation of canine atrial fibrillation, and diagnosis and intervention for arrhythmias - Physiological and metabolic effects of interruptions in chest compressions during cardiopulmonary resuscitation Henry Halperin, MD, is co-director of the Johns Hopkins Imaging Institute of Excellence and a professor of medicine, radiology and biomedical engineering. Menekhem M. Zviman, PhD is the laboratory manager.

Selected Publications

• 1. Dickfeld T, Calkins H, Zviman M, Kato R, Meininger G, Lickfett L, Berger R, Halperin H, Solomon SB: Anatomic stereotactic catheter ablation on three-dimensional magnetic resonance images in real time. Circulation. 2003 Nov 11;108(19):2407-13. Epub 2003 Oct 20.

  
  2. Roguin A, Zviman M, Meininger G, Rodriguez ER, Dickfeld T, Bluemke D, Lardo A, Berger R, Calkins H, Halperin H: Modern pacemaker and implantable cardioverter-defibrillator systems can be MRI safe: In-vitro and in-vivo assessment of safety and function at 1.5-Tesla. Circulation. 2004 Aug 3;110(5):475-82.

  
  3. Nazarian S, S, Bluemke D, Lardo A, Zviman M, Watkins S, Dickfeld T, Meininger G, Roguin A, Calkins H, Tomaselli G, Weiss RG, Berger R, Lima J, Halperin H: Magnetic resonance assessment of the substrate for inducible ventricular tachycardia in non-ischemic cardiomyopathy. Circulation. 2005;112:2821-5.

  
  4. Dickfeld T, Kato R , Zviman M, Meininger G , Lardo A , Roguin A, Bluemke D, Berger R, Calkins H, Halperin H: Characterization of radiofrequency ablation lesions with gadolinium-enhanced cardiovascular magnetic resonance imaging. J Am Coll Cardiol. 2006;47:370-8.

  
  5. Dong J, Calkins H, Solomon SB, Lai S, Dalal D, Lardo A, Brem E, Preiss A, Berger RD, Halperin H, Dickfeld T. Integrated electroanatomic mapping with three-dimensional computed tomographic images for real-time guided ablations. Circulation. 2006;113:186-94.

  
  6. Lardo AC, Cordeiro MA, Silva C, Amado LC, George RT, Saliaris AP, Schuleri KH, Fernandes VR, Zviman M, Nazarian S, Halperin HR, Wu KC, Hare JM, Lima JA. Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar. Circulation. 2006;113:394-404

  
  7. Nazarian S, Roguin A, Zviman M, Lardo A, Dickfeld T, Calkins H , Berger R, Bluemke D, Halperin H: Clinical Utility and Safety of a Protocol for Non-Cardiac and Cardiac Magnetic Resonance Imaging of Patients with Permanent Pacemakers and Implantable Cardioverter Defibrillators at 1.5 Tesla. Circulation. 2006;114(12):1277-84. Epub 2006 (Featured)

  
  8. Dickfeld T, Kato R, Zviman M, Nazarian S, Dong J, Ashikaga H, Lardo AC, Berger RD, Calkins H, Halperin H.Characterization of acute and subacute radiofrequency ablation lesions with nonenhanced magnetic resonance imaging. Heart Rhythm. 2007 Feb;4(2):208-14.

  
  9. Halperin, H; American Heart Association: Recommendations for implementation of community consultation and public disclosure under the Food and Drug Administration "exception from informed consent requirements for emergency research": testimony of the American Heart Association. Acad Emerg Med. 2007 Apr;14(4):e37-9.

  
  10. Halperin H, Paradis N, Mosesso V Jr, Nichol G, Sayre M, Ornato JP, Gerardi M, Nadkarni VM, Berg R, Becker L, Siegler M, Collins M, Cairns CB, Biros MH, Vanden Hoek T, Peberdy MA: Recommendations for implementation of community consultation and public disclosure under the Food and Drug Administration's "Exception from informed consent requirements for emergency research": A special report from the American Heart Association Emergency Cardiovascular Care Committee and Council on Cardiopulmonary, Perioperative and Critical Care: Endorsed by the American College of Emergency Physicians and the Society for Academic Emergency Medicine. Circulation. 2007 Oct 16;116(16):1855-63. Epub 2007 Sep 24. [Comment in JAMA. 2007;298(22):2608-2609].

  
  11. Berger RD, Palazzolo J, Halperin H. Rhythm discrimination during uninterrupted CPR using motion artifact reduction system. Resuscitation. 2007 Oct;75(1):145-52. Epub 2007 Apr 30.

  
  12. Tandri H, Zviman MM, Wedan SR, Lloyd T, Berger RD, Halperin H. Determinants of gradient field-induced current in a pacemaker lead system in a magnetic resonance imaging environment. Heart Rhythm. 2008 Mar;5(3):462-8. Epub 2007 Dec 27.

  
  13. Nazarian S, Kolandaivelu A, Zviman MM, Meininger G, Kato R, Susil R, Roguin A, Dickfeld T, Ashikaga H, Calkins H, Berger RD, Bluemke D, Lardo A, Halperin HR: Feasibility of real-time magnetic resonance imaging for catheter guidance in electrophysiology studies. Circulation. 2008 Jul 15;118(3):223-9.

  
  14. Nazarian S, Kantsevoy SV, Zviman MM, Matsen FA 3rd, Calkins H, Berger RD, Halperin HR: Feasibility of endoscopic guidance for nonsurgical transthoracic atrial and ventricular epicardial ablation. Heart Rhythm. 2008 Aug;5(8):1115-9. Epub 2008 May 9.
   

Patents

• ECG Artifact Reduction System,

  An ECG signal processing system which removes the CPR-induced artifact from measured ECG signals obtained during the administration of CPR.

  US8666480 B2, 3/4/14
• CPR Chest Compression Monitor and Method of Use,

  A chest compressions monitor for measuring the depth of chest compressions achieved during CPR. A displacement detector produces a displacement indicative signal indicative of the displacement of the CPR recipient's chest toward the recipient's spine. A signaling mechanism provides chest compression indication signals directing a chest compression force being applied to the chest and a frequency of such compressions.

  US8968224 B2, 3/3/15
• CPR Chest Compression Monitor And Method of Use,

  A chest compressions monitor for measuring the depth of chest compressions achieved during CPR. A displacement detector produces a displacement indicative signal indicative of the displacement of the CPR recipient's chest toward the recipient's spine. A signaling mechanism provides chest compression indication signals directing a chest compression force being applied to the chest and a frequency of such compressions.

  US8147433 B2, 4/3/12
• Band Stop Filter Employing a Capacitor And an Inductor Tank Circuit to Enhance MRI Compatibility of Active Medical Devices,

  A band stop filter is provided for a lead wire of an active medical device (AMD). The band stop filter includes a capacitor in parallel with an inductor. The parallel capacitor and inductor are placed in series with the lead wire of the AMD, wherein values of capacitance and inductance are selected such that the band stop filter has a Q with the resultant 3 dB bandwidth being in the megahertz range. The Q of the inductor may be relatively maximized and the Q of the capacitor may be relatively minimized to reduce the overall Q of the band stop filter to attenuate current flow through the lead wire along a range of selected frequencies. In a preferred form, the band stop filter is integrated into a TIP and/or RING electrode for an active implantable medical device.

  US8275466 B2, 9/25/12
• Band Stop Filter Employing a Capacitor And an Inductor Tank Circuit to Enhance MRI Compatibility of Active Medical Devices,

  A band stop filter is provided for a lead wire of an active medical device (AMD). The band stop filter includes a capacitor in parallel with an inductor. The parallel capacitor and inductor are placed in series with the lead wire of the AMD, wherein values of capacitance and inductance are selected such that the band stop filter is resonant at a selected frequency. The Q of the inductor may be relatively maximized and the Q of the capacitor may be relatively minimized to reduce the overall Q of the band stop filter to attenuate current flow through the lead wire along a range of selected frequencies. In a preferred form, the band stop filter is integrated into a TIP and/or RING electrode for an active implantable medical device.

  US8897887 B2, 11/25/14
• Band stop filter employing a capacitor and an inductor tank,

  Band stop filter employing a capacitor and an inductor tank circuit to enhance MRI compatibility of active implantable medical devices.

  US7363090 B, 4/22/08

Honors

• Fellow, American Heart Association, 1/1/01
• McClure Fellow, Johns Hopkins Applied Physics Laboratory, 1/1/98
• Established Investigator, American Heart Association, 1/1/89
• Physician Scientist, National Institutes of Health, 1/1/84
• Richard King Award for Outstanding Senior, Purdue University, 1/1/71
• B.S. With Highest Distinction, Purdue University, 1/1/71
• National Science Foundation Fellowship, 1/1/71
• Phi Beta Kappa, 1/1/70
• Eagle Scout, 1/1/64

Memberships

• American Heart Association
• Electrophysiology Society
• Heart Rhythm Society