Hao Wang, PhD

Primary Academic Title

Professor of Oncology

Background

Centers and Institutes

Sidney Kimmel Comprehensive Cancer Center

Research Interests

Clinical trial design methods integrating biomarkers to identify subgroups who will benefit from a therapy, Longitudinal data analysis., Missing or coarsened data analysis, Statistical methods of biomarker evaluations

Research Summary

Dr. Wang is interested in developing statistical methods to address problems in biomedical research. She has an extensive collaborative experience in translational and clinical cancer research, cancer prevention and control, as well as AIDS and kidney disease. She provides statistical support through the Kimmel Cancer Center Shared Resources.

PubMed

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/47273742/?sort=date&direction=descending

Selected Publications

• Antonarakis ES, Lu C, Wang H, Luber B, Nakazawa M, Roeser JC, Chen Y, Mohammad TA, Chen Y, Fedor HL, Lotan TL, Zheng Q, De Marzo AM, Isaacs JT, Isaacs WB, Nadal R, Paller CJ, Denmeade SR, Carducci MA, Eisenberger MA, Luo J. AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. N Engl J Med. 2014 Sep 11;371(11):1028-1038. PMCID: PMC4201502.

• Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, Bartlett BR, Wang H, Luber B, Alani RM, Antonarakis ES, Azad NS, Bardelli A, Brem H, Cameron JL, Lee CC, Fecher LA, Gallia GL, Gibbs P, Le D, Giuntoli RL, Goggins M, Hogarty MD, Holdhoff M, Hong SM, Jiao Y, Juhl HH, Kim JJ, Siravegna G, Laheru DA, Lauricella C, Lim M, Lipson EJ, Marie SK, Netto GJ, Oliner KS, Olivi A, Olsson L, Riggins GJ, Sartore-Bianchi A, Schmidt K, Shih lM, Oba-Shinjo SM, Siena S, Theodorescu D, Tie J, Harkins TT, Veronese S, Wang TL, Weingart JD, Wolfgang CL, Wood LD, Xing D, Hruban RH, Wu J, Allen PJ, Schmidt CM, Choti MA, Velculescu VE, Kinzler KW, Vogelstein B, Papadopoulos N, Diaz LA Jr. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med. 2014 Feb 19;6(224):224ra24. doi: 10.1126/scitranslmed.3007094. PMCID: PMC4017867 

• Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, Biedrzycki B, Donehower RC, Zaheer A, Fisher GA, Crocenzi TS, Lee JJ, Duffy SM, Goldberg RM, de la Chapelle A, Koshiji M, Bhaijee F, Huebner T, Hruban RH, Wood LD, Cuka N, Pardoll DM, Papadopoulos N, Kinzler KW, Zhou S, Cornish TC, Taube JM, Anders RA, Eshleman JR, Vogelstein B, Diaz LA Jr. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 2015 Jun 25; 372(26):2509-2520. PMCID: PMC4481136

• Wang H, and Heitjan DF. Modeling heaping in self-reported cigarette counts. Statistics in Medicine. 2008;27(19):3789-804. PMCID:PMC2684113. 

• Wang H, Rosner GL, Goodman SN. Quantifying over-estimation in early-stopped clinical trials and the “freezing effect” on subsequent research. Clinical Trials. In press.