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Hanghang Wang

Hanghang Wang, MD, PhD

Cardiothoracic Surgery

Accepting New Patients
Johns Hopkins Affiliations:
  • Johns Hopkins School of Medicine Faculty

Languages

  • Chinese
  • English

14 Insurances Accepted

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Gender

Female

About Hanghang Wang

Primary Academic Title

Assistant Professor of Cardiac Surgery

Background

Hanghang Wang, M.D., Ph.D. is a Cardiac Surgeon at Suburban Hospital and an Assistant Professor of Surgery at the Johns Hopkins School of Medicine. Dr. Wang received her bachelor’s degree in Biology from Grinnell College, M.D. from Dartmouth Medical School and Ph.D. in Computational Biology & Bioinformatics from Duke University. She also holds a Certificate in College Teaching from Duke University. She completed her general surgery residency at Duke University Medical Center and cardiothoracic surgery fellowship at Johns Hopkins, where she received comprehensive training in mitral valve repair, CABG surgery (both on- and off-pump), and aortic surgery. Further specialized training includes complex mitral and aortic surgeries at the University of Toronto and aortic dissection at one of the world's leading centers for the condition.

Dr. Wang practices all aspects of cardiac surgery, with a special interest in the mitral valve repair surgery. She also has a keen interest in aortic surgery, including aortic dissections.

Dr. Wang leads a translational research lab that intersects cardiac surgery, computational biology, and bioengineering. She has made significant contributions to cardiovascular disease research, discovering novel biomarkers and standardizing metabolomic profiling protocols. She has also played a key role in establishing a comprehensive aortic disease registry and tissue biorepository. Dr. Wang has presented her work at many national and international conferences and has published her work in high-impact journals such as JAMA Cardiology and Circulation.

Her current research projects include:

  • Biomarker Discovery: Aiming to identify novel biomarkers for the rapid diagnosis of acute Type A aortic dissection.
  • Integrative Omics: Utilizing omics approaches for the personalized management of degenerative mitral regurgitation.
  • AI in Surgery: Working on the development of AI-assisted personalized surgical planning for mitral valve repair.

Recent News Articles and Media Coverage

Research Interests

Artificial Intelligence, Bioengineering, Computational Biology, Machine Learning, Omics, Precision Medicine

Lab Website

Cardiovascular Precision Medicine Laboratory - Lab Website

  • The Cardiovascular Precision Medicine Laboratory led by Dr. Hanghang Wang operates at the intersection of cardiac surgery, computational biology, and bioengineering. With a focus on precision medicine, we are dedicated to creating personalized diagnostic and treatment modalities for cardiovascular diseases, integrating cutting-edge research into clinical practice. Our laboratory is also an integral component of the Broccoli Aortic Center for Aortic Diseases, further enhancing our research capabilities and clinical impact.

Selected Publications

  • Wang H, Wagner M, Benrashid E, Keenan J, Wang A, Ranney D, Yerokun B, Gaca JG, McCann RL, Hughes GC. Outcomes of Reoperation After Acute Type A Aortic Dissection: Implications for Index Repair Strategy. J Am Heart Assoc. 2017 Oct 3;6(10). doi: 10.1161/JAHA.117.006376. PubMed PMID: 28974497; PubMed Central PMCID: PMC5721847

  • Wang H, Anstrom K, Ilkayeva O, Muehlbauer MJ, Bain JR, McNulty S, Newgard CB, Kraus WE, Hernandez A, Felker GM, Redfield M, Shah SH. Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial. JAMA Cardiol. 2017 Aug 1;2(8):896-901. doi: 10.1001/jamacardio.2017.1239. PubMed PMID: 28492915; PubMed Central PMCID: PMC5815079

  • Wang H, Hanna JM, Ganapathi A, Keenan JE, Hurwitz LM, Vavalle JP, Kiefer TL, Wang A, Harrison JK, Hughes GC. Comparison of aortic annulus size by transesophageal echocardiography and computed tomography angiography with direct surgical measurement. Am J Cardiol. 2015 Jun 1;115(11):1568-73. doi: 10.1016/j.amjcard.2015.02.060. Epub 2015 Mar 12. PubMed PMID: 25846765

  • Wang H, Muehlbauer MJ, O'Neal SK, Newgard CB, Hauser ER, Bain JR, Shah SH. Recommendations for Improving Identification and Quantification in Non-Targeted, GC-MS-Based Metabolomic Profiling of Human Plasma. Metabolites. 2017 Aug 25;7(3). doi: 10.3390/metabo7030045. PubMed PMID: 28841195; PubMed Central PMCID: PMC5618330

  • Hahn VS, Petucci C, Kim MS, Bedi KC Jr, Wang H, Mishra S, Koleini N, Yoo EJ, Margulies KB, Arany Z, Kelly DP, Kass DA, Sharma K. Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction. Circulation. 2023 Apr 11;147(15):1147-1161. doi: 10.1161/CIRCULATIONAHA.122.061846. Epub 2023 Mar 1. PubMed PMID: 36856044.

Honors

  • AATS Leadership Academy, 2023
  • AATS Foundation Honoring Our Cleveland Clinic Mentors Leadership Program, 2022
  • AATS Foundation Thoracic Surgical Robotics Fellowship, 2021 - 2022
  • AHA FGTB Young Investigator Abstract Travel Award, 2016
  • Thoracic Surgery Foundation for Research and Education Braunwald Fellowship, 2015 - 2017
  • NIH T32 National Research Service Award, NIH, 2015 - 2017
  • Women in Thoracic Surgery (WTS) Scholarship, 2010
  • Summer Fellowship, Memorial Sloan Kettering Cancer Center, 2009
  • AATS Summer Scholarship, 2009
  • Summer Scholar in Thoracic Surgery, Massachusetts General Hospital, 2008
  • Outstanding Commitment to Community Service, Grinnell College, 2007
  • Smith Family Award in Biology, Grinnell College, 2007
  • Joseph F. Wall Scholarship, Grinnell College, 2006
  • High Academic Achievement, Institute for the International Education of Students, 2006
  • Berlin Minority Scholarship, Institute for the International Education of Student, 2006

Lectures & Presentations

  • Wide Variation in Mitral Valve Repair Rates Among U.S. Surgeons: Analysis of Medicare Claims Data, Western Thoracic Surgical Association Annual Meeting, June 2024
  • Precision Medicine in Motion: The Ballet of Mitral Valve Repair, Suburban Hospital Johns Hopkins Medicine Grand Rounds, June 2024
  • The Heart of Resilience: Empowering Lifelong Cardiovascular Wellness, US Army Public Health Command, East, April 2024
  • Educating Surgeons of Tomorrow: A Johns Hopkins Odyssey, Xiangyang Central Hospital Grand Rounds, Xiangyang, China, April 2024
  • Pioneering to Personalization: The Evolution of Cardiac Surgery at Johns Hopkins, Beijing Aerospace General Hospital Grand Rounds, Beijing, China, April 2024
  • AI and Medicine: The Transformative Role of Artificial Intelligence in Healthcare, Johns Hopkins Development & Alumni Relations Talent Conference, April 2024
  • Artificial Intelligence and Aortic Disease, International Aortic Disease Forum, Nanjing, China, September 2023
  • Robotic Repair of Tracheal Injury, General Thoracic Surgical Club Annual Meeting, Duke Key, FL, March 2023

Memberships

  • Southern Thoracic Surgical Association, Member
  • Physician Scientist Training Program Scholars at Johns Hopkins Hospital
  • Society of Thoracic Surgeons
  • The Robert J. Lefkowitz Society at Duke Medicine
  • American Heart Association
  • Women in Thoracic Surgery
  • Dartmouth-Mosenthal Surgical Society
  • Mortar Board National Honor Society
  • Phi Beta Kappa Honor Society

Locations

  1. Suburban Hospital
    • 8600 Old Georgetown Road, Bethesda, MD 20814
    • JH Cardiac Surgery
      • 97 Thomas Johnson Drive, Suite 202, Frederick, MD 21702

      Expertise

      Education

      Johns Hopkins University School of Medicine

      Residency, Cardiothoracic Surgery, 2023

      Duke University Hospital

      Residency, Surgery, 2020

      Duke University

      Graduate School, PhD, 2017

      Duke University Hospital

      Residency, Surgery, 2013

      Geisel School of Medicine at Dartmouth

      Medical Education, MD, 2011

      Board Certifications

      Thoracic and Cardiac Surgery

      American Board of Thoracic Surgery, 2024

      Insurance

      Johns Hopkins providers accept various commercial health insurance plans. However, they may not be included in all of an insurance company's plans or offerings. This may include Exchange, Medicaid, Medicare, and specific limited benefit plans. Exceptions to participation also exist based on your employer’s benefits package and the provider's location or specialty. Please contact your insurer directly to make sure your doctor is covered by your plan. For more details, please review our Insurance Information.
      Search plans
      • Aetna
      • CareFirst
      • Cigna
      • First Health
      • Geisinger Health Plan
      • HealthSmart/Accel
      • Humana
      • Johns Hopkins Health Plans
      • MultiPlan
      • Pennsylvania's Preferred Health Networks (PPHN)
      • Point Comfort Underwriters
      • Private Healthcare Systems (PHCS)
      • UnitedHealthcare
      • Veteran Affairs Community Care Network (Optum-VACCN)