George Sgouros, PhD
Highlights
Languages
- English
Gender
MaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About George Sgouros
Professional Titles
- Director, Radiological Physics Division
Primary Academic Title
Professor of Radiology and Radiological Science
Background
Dr. George Sgouros is a Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science, Department of Radiation Oncology and Department of Oncology and a member of the Johns Hopkins Kimmel Cancer Center. His research focuses on modeling and dosimetry of internally administered radionuclides with a particular emphasis on patient-specific dosimetry, alpha-particle dosimetry, and mathematical modeling of radionuclide therapy. Dr. Sgouros is Director of the Radiological Physics Division of the Russell H. Morgan Department of Radiology and Radiological Science.
Dr. Sgouros received his undergraduate degree in applied physics from Columbia University. He earned his Ph.D. from Cornell University and performed a fellowship in medical physics at Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center in New York. Dr. Sgouros joined the Johns Hopkins faculty in 2003.
Prior to joining Johns Hopkins, Dr. Sgouros was an Associate Professor in Radiology at Cornell University and an Associate Attending Physicist at Memorial Sloan-Kettering Cancer Center.
Dr. Sgouros' research interests include targeted radionuclide therapy, radioimmunotherapy, dosimetry, pharmacokinetic modeling, and alpha-particle emitters. He is author on more than 140 peer-reviewed articles.
Dr. Sgouros serves as chairman of the Medical Internal Radionuclide Dose (MIRD) Committee of the Society of Nuclear Medicine and Molecular Imaging. He has received a number of awards including the 2001 CaP CURE Award and the Society of Nuclear Medicine and Molecular Imaging, Saul Hertz Award which honors outstanding achievements and contributions in radionuclide therapy. Dr. Sgouros is a member of the National Council on Radiation Protection and Measurements (NCRP). He is a member of the International Commission on Radiation Units and Measurements (ICRU), Report Committee on “Bioeffect Modeling and Equieffective Dose Concepts in Radiation Therapy” and chair of Report Committee 31 on “Treatment Planning for Radiopharmaceutical Therapy.” He is also a member of the Scientific Committee of the IAEA/WHO Network of Secondary Standards Dosimetry Laboratories. Dr. Sgouros was a member of the NIH study section on Radiation Therapeutics and Biology (RTB) from 2013 to 2017 and chair of RTB from 2015 to 2017.
Centers and Institutes
Clinical Trials Summary
Safety and Efficacy Study of I-131 Tositumomab in Patients With Relapsed/Refractory Hodgkin's Lymphoma
Additional Academic Titles
Professor of Radiation Oncology and Molecular Radiation Sciences, Professor of Oncology
Research Interests
Alpha-particle emitters, Dosimetry, Pharmacokinetic modeling, Radioimmunotherapy, Targeted radionuclide therapy
Lab Website
Sgouros RTD Lab at Johns Hopkins Medicine - Lab Website
The Sgouros Radionuclide Therapy and Dosimetry Research Lab is focused on modeling and dosimetry analysis of radionuclide therapy to support the translation of novel targeted radionuclide therapy strategies to the clinic. The research is divided between laboratory studies and patient-specific dosimetry/radiobiological modeling studies. Dr. Sgouros’ lab is currently engaged in pre-clinical research investigating targeted alpha-emitter therapy of metastatic cancer.
Research Summary
Dr. Sgouros’ research over the past 20 years has focused on modeling and dosimetry of internally administered radionuclides with a particular emphasis on patient-specific dosimetry, alpha-particle dosimetry, and mathematical modeling of radionuclide therapy.
Selected Publications
Cheng L, Hobbs RF, Segars PW, Sgouros G, Frey EC. “Improved dose-volume histogram estimates for radiopharmaceutical therapy by optimizing quantitative SPECT reconstruction parameters.” Phys Med Biol. 2013 Jun 7;58(11):3631-47. doi: 10.1088/0031-9155/58/11/3631. Epub 2013 May 7
Hobbs RF, Jentzen W, Bockisch A, Sgouros G. “Monte Carlo-based 3-dimensional dosimetry of salivary glands in radioiodine treatment of differentiated thyroid cancer estimated using 124I PET.” Q J Nucl Med Mol Imaging. 2013 Mar;57(1):79-91.
Hobbs RF, Wahl RL, Frey EC, Kasamon Y, Song H, Huang P, Jones RJ, Sgouros G. “Radiobiologic optimization of combination radiopharmaceutical therapy applied to myeloablative treatment of non-Hodgkin lymphoma.” J Nucl Med. 2013 Sep;54(9):1535-42. doi: 10.2967/jnumed.112.117952. Epub 2013 Aug 5
Meghzifene A, Sgouros G. “IAEA support to medical physics in nuclear medicine.” Semin Nucl Med. 2013 May;43(3):181-7. doi: 10.1053/j.semnuclmed.2012.11.008
Song H, Hedayati M, Hobbs RF, Shao C, Bruchertseifer F, Morgenstern A, Deweese TL, Sgouros G. “Targeting Aberrant DNA Double-Strand Break Repair in Triple-Negative Breast Cancer with Alpha-Particle Emitter Radiolabeled Anti-EGFR Antibody.” Mol Cancer Ther. 2013 Oct;12(10):2043-54. doi: 10.1158/1535-7163.MCT-13-0108. Epub 2013 Jul 19.
Honors
- Saul Hertz Award, Society of Nuclear Medicine and Molecular Imaging, 6/9/17
- Organizing Committee Member, International Symposium on Standards, 1/1/09
- Chairman, Medical Internal Radiation Dose (MIRD) Committee Society of Nuclear Medicine, 1/1/08
- Invited faculty, International Atomic Energy Association (IAEA) Training Course on Medical Physics, 1/1/07
- Member, National Council on Radiation Protection and Measurements (NCRP), 1/1/05
- Oncological Sciences IRG Study Section Boundaries Team member, NIH, Center for Scientific Review, 1/1/01
- CaP CURE Award, 1/1/01
Memberships
- American Association of Physicists in Medicine (AAPM), Steering Committee Member, Task Group on Internal Emitter Dosimetry
- National Council on Radiation Protection and Measurements (NCRP), Member, Committee on Uncertainties in Internal Radiation Dosimetry
Professional Activities
- International Commission on Radiological Protection, Chairman, Report Committee 31 on Dosimetry for Radiopharmaceutical Therapy, 5/8/17
- Medical Internal Radionuclide Dose (MIRD) Committee, Chairman
- National Institutes of Health, Chairman, Radiation Therapeutics and Biology Study Section, 2/2/15 - 6/30/17
Additional Training
Sloan-Kettering Institute Memorial Sloan-Kettering Cancer Center, New York, New York, 1993, Post-Doctoral Research Fellow (Medical Physics)