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Ephraim J. Fuchs

Ephraim J. Fuchs, MD

Hematologic Malignancy

Accepting New Patients
Johns Hopkins Affiliations:
  • Johns Hopkins School of Medicine Faculty

Languages

  • English

14 Insurances Accepted

View all

Gender

Male

About Ephraim J. Fuchs

Primary Academic Title

Professor of Oncology

Clinical Trial Keywords

bone marrow transplant; lymphoma; leukemia

Research Interests

bone marrow transplant, myeloid disorders

Selected Publications

  • Durakovic, N.; Bezak, K.B.; Skarica, M.; Radojcic, V.; Fuchs, E.J.; Murphy, G.F.; Luznik, L. Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions. J Immunol. 2006 Oct 1;177(7):4414-4425.

    Huff, C.A.; Fuchs, E.J.; Smith, B.D.; Blackford, A.; Garrett-Mayer, E.; Brodsky, R.A.; Flinn, I.W.; Ambinder, R.F.; Borrello, I.M.; Matsui, W.H.; Vogelsang, G.B.; Griffin, C.A.; Luznik, L.; Jones, R.J. Graft-versus-host reactions and the effectiveness of donor lymphocyte infusions. Biol Blood Marrow Transplant. 2006 Apr;12(4):414-421.

    Ravi, R.; Fuchs, E.J.; Jain, A.; Pham, V.; Yoshimura, K.; Prouser, T.; Jalla, S.; Zhou, X.; Garrett-Mayer, E.; Kaufmann, S.H.; Schulick, R.D.; Pardoll, D.M.; Bedi, A. Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling. Cancer Res. 2006 Feb 1;66(3):1730-1739.

    Wu, K.; Giovannucci, E.; Byrne, C.; Platz, E.A.; Fuchs, C.; Willett, W.C.; Sinha, R. Meat mutagens and risk of distal colon adenoma in a cohort of U.S. men. Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1120-1125.

    Bolanos-Meade, J.; Garrett-Mayer, E.; Luznik, L.; Anders, V.; Webb, J.; Fuchs, E.J.; Huff, C.A.; Matsui, W.; Borrello, I.M.; Brodsky, R.; Kasamon, Y.L.; Swinnen, L.J.; Flinn, I.W.; Ambinder, R.F.; Jones, R.J.; Hess, A.D.; Vogelsang, G.B. Induction of autologous graft-versus-host disease: results of a randomized prospective clinical trial in patients with poor risk lymphoma. Biol Blood Marrow Transplant. 2007 Oct;13(10):1185-1191.

    Durakovic, N.; Radojcic, V.; Skarica, M.; Bezak, K.B.; Powell, J.D.; Fuchs, E.J.; Luznik, L. Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse. Blood. 2007 May 15;109(10):4564-4574.

    Fuchs, E.J.; Lee, L.A.; Torbenson, M.S.; Parsons, T.L.; Bakshi, R.P.; Guidos, A.M.; Wahl, R.L.; Hendrix, C.W. Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission. J Infect Dis. 2007 Mar 1;195(5):703-710.

    Thimmulappa, R.K.; Fuchs, R.J.; Malhotra, D.; Scollick, C.; Traore, K.; Bream, J.H.; Trush, M.A.; Liby, K.T.; Sporn, M.B.; Kensler, T.W.; Biswal, S. Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxid Redox Signal. 2007 Nov;9(11):1963-1970.

    Brodsky, R.A.; Luznik, L.; Bolanos-Meade, J.; Leffell, M.S.; Jones, R.J.; Fuchs, E.J. Reduced intensity HLA-haploidentical BMT with post transplantation cyclophosphamide in nonmalignant hematologic diseases. Bone Marrow Transplant. 2008 Oct;42(8):523-527.

    Luznik, L.; O''Donnell, P.V.; Symons, H.J.; Chen, A.R.; Leffell, M.S.; Zahurak, M.; Gooley, T.A.; Piantadosi, S.; Kaup, M.; Ambinder, R.F.; Huff, C.A.; Matsui, W.; Bolanos-Meade, J.; Borrello, I.; Powell, J.D.; Harrington, E.; Warnock, S.; Flowers, M.; Brodsky, R.A.; Sandmaier, B.M.; Storb, R.F.; Jones, R.J.; Fuchs, E.J. HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant. 2008 Jun;14(6):641-650.

    Symons, H.J.; Levy, M.Y.; Wang, J.; Zhou, X.; Zhou, G.; Cohen, S.E.; Luznik, L.; Levitsky, H.I.; Fuchs, E.J. The allogeneic effect revisited: exogenous help for endogenous, tumor-specific T cells. Biol Blood Marrow Transplant. 2008 May;14(5):499-509.

    Warlick, E.D.; O''Donnell, P.V.; Borowitz, M.; Grupka, N.; Decloe, L.; Garrett-Mayer, E.; Borrello, I.; Brodsky, R.; Fuchs, E.; Huff, C.A.; Luznik, L.; Matsui, W.; Ambinder, R.; Jones, R.J.; Douglas Smith, B. Myeloablative allogeneic bone marrow transplant using T cell depleted allografts followed by post-transplant GM-CSF in high-risk myelodysplastic syndromes. Leuk Res. 2008 Sep;32(9):1439-1447.

    Bolanos-Meade, J.; Luznik, L.; Muth, M.; Matsui, W.H.; Huff, C.A.; Smith, B.D.; Levy, M.Y.; Kasamon, Y.L.; Swinnen, L.J.; Powell, J.D.; Brodsky, R.A.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Salvage transplantation for allograft failure using fludarabine and alemtuzumab as conditioning regimen. Bone Marrow Transplant. 2009 Mar;43(6):477-480.

    Fuchs, E.J.; Huang, X.J.; Miller, J.S. HLA-haploidentical stem cell transplantation for hematologic malignancies. Biol Blood Marrow Transplant. 2009 Nov 2.

    Fuchs, E.J.; Luznik, L.; Bolanos-Meade, J.; Miller, C.B.; Brodsky, R.A.; Ambinder, R.F.; Jones, R.J. Successful pregnancy and childbirth after reduced-intensity conditioning and partially HLA-mismatched BMT. Bone Marrow Transplant. 2009 Jun;43(12):969-970.

    Kasamon, Y.L.; Luznik, L.; Leffell, M.S.; Kowalski, J.; Tsai, H.L.; Bolanos-Meade, J.; Morris, L.E.; Crilley, P.A.; O''Donnell, P.V.; Rossiter, N.; Huff, C.A.; Brodsky, R.A.; Matsui, W.H.; Swinnen, L.J.; Borrello, I.; Powell, J.D.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Nonmyeloablative HLA-Haploidentical BMT with High-Dose Posttransplantation Cyclophosphamide: Effect of HLA Disparity on Outcome. Biol Blood Marrow Transplant. 2009 Nov 16.

    Leffell, M.S.; Cao, K.; Coppage, M.; Hansen, J.A.; Hart, J.M.; Pereira, N.; Pereira, S.; Reinsmoen, N.L.; Senitzer, D.; Smith, A.; Torres, M.; Vega, R.; Fuchs, E. Incidence of humoral sensitization in HLA partially mismatched hematopoietic stem cell transplantation. Tissue Antigens. 2009 Oct 4;74:494-498.

    Levy, M.Y.; Sidana, A.; Chowdhury, W.H.; Solomon, S.B.; Drake, C.G.; Rodriguez, R.; Fuchs, E.J. Cyclophosphamide unmasks an antimetastatic effect of local tumor cryoablation. J Pharmacol Exp Ther. 2009 Aug;330(2):596-601.

    Oster, S.F.; Ebrahimi, K.B.; Eberhart, C.G.; Schein, O.D.; Stark, W.J.; Jun, A.S. A clinicopathologic series of primary graft failure after Descemet''s stripping and automated endothelial keratoplasty. Ophthalmology. 2009 Apr;116(4):609-614.

    Wu, K.; Platz, E.A.; Willett, W.C.; Fuchs, C.S.; Selhub, J.; Rosner, B.A.; Hunter, D.J.; Giovannucci, E. A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma. The American journal of clinical nutrition. 2009 Dec;90(6):1623-1631.

    Bolanos-Meade, J.; Smith, B.D.; Gore, S.D.; McDevitt, M.A.; Luznik, L.; Fuchs, E.J.; Jones, R.J. 5-Azacytidine as Salvage Treatment in Relapsed Myeloid Tumors after Allogeneic Bone Marrow Transplantation. Biol Blood Marrow Transplant. 2010 Oct 15;In Press.

    Brodsky, R.A.; Chen, A.R.; Dorr, D.; Fuchs, E.J.; Huff, C.A.; Luznik, L.; Smith, B.D.; Matsui, W.H.; Goodman, S.N.; Ambinder, R.F.; Jones, R.J. High-dose cyclophosphamide for severe aplastic anemia: long-term follow-up. Blood. 2010 Mar 18;115(11):2136-2141.

    Chen, J.; Garner, R.C.; Lee, L.S.; Seymour, M.; Fuchs, E.J.; Hubbard, W.C.; Parsons, T.L.; Pakes, G.E.; Fletcher, C.V.; Flexner, C. Accelerator mass spectrometry measurement of intracellular concentrations of active drug metabolites in human target cells in vivo. Clin Pharmacol Ther. 2010 Dec;88(6):796-800.

    Dezern, A.E.; Luznik, L.; Fuchs, E.J.; Jones, R.J.; Brodsky, R.A. Post-transplantation cyclophosphamide for GVHD prophylaxis in severe aplastic anemia. Bone Marrow Transplant. 2010 Sep 13.

    Engler, C.; Kelliher, C.; Spitze, A.R.; Speck, C.L.; Eberhart, C.G.; Jun, A.S. Unfolded protein response in fuchs endothelial corneal dystrophy: a unifying pathogenic pathway? Am J Ophthalmol. 2010 Feb;149(2):194-202 e192.

    Engstrom, P.F.; Arnoletti, J.P.; Benson, A.B., 3rd; Berlin, J.D.; Berry, J.M.; Chen, Y.J.; Choti, M.A.; Cooper, H.S.; Dilawari, R.A.; Early, D.S.; Enzinger, P.C.; Fakih, M.G.; Fleshman, J., Jr.; Fuchs, C.; Grem, J.L.; Knol, J.A.; Leong, L.A.; Lin, E.; Mulcahy, M.F.; Rohren, E.; Ryan, D.P.; Saltz, L.; Shibata, D.; Skibber, J.M.; Small, W.; Sofocleous, C.; Thomas, J.; Venook, A.P.; Willett, C. NCCN clinical practice guidelines in oncology. Anal carcinoma. J Natl Compr Canc Netw. 2010 Jan;8(1):106-120.

    Fuchs, E.J.; Huang, X.J.; Miller, J.S. HLA-haploidentical stem cell transplantation for hematologic malignancies. Biol Blood Marrow Transplant. 2010 Jan;16(1 Suppl):S57-63.
    Kasamon, Y.L.; Jones, R.J.; Brodsky, R.A.; Fuchs, E.J.; Matsui, W.; Luznik, L.; Powell, J.D.; Blackford, A.L.; Goodrich, A.; Gocke, C.D.; Abrams, R.A.; Ambinder, R.F.; Flinn, I.W. Immunologic recovery following autologous stem-cell transplantation with pre- and posttransplantation rituximab for low-grade or mantle cell lymphoma. Ann Oncol. 2010 Jun;21(6):1203-1210.

    Kasamon, Y.L.; Luznik, L.; Leffell, M.S.; Kowalski, J.; Tsai, H.L.; Bolanos-Meade, J.; Morris, L.E.; Crilley, P.A.; O''Donnell, P.V.; Rossiter, N.; Huff, C.A.; Brodsky, R.A.; Matsui, W.H.; Swinnen, L.J.; Borrello, I.; Powell, J.D.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Nonmyeloablative HLA-haploidentical bone marrow transplantation with high-dose posttransplantation cyclophosphamide: effect of HLA disparity on outcome. Biol Blood Marrow Transplant. 2010 Apr;16(4):482-489.

    Luznik, L.; Bolanos-Meade, J.; Zahurak, M.; Chen, A.R.; Smith, B.D.; Brodsky, R.; Huff, C.A.; Borrello, I.; Matsui, W.; Powell, J.D.; Kasamon, Y.; Goodman, S.N.; Hess, A.; Levitsky, H.I.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease. Blood. 2010 Apr 22;115(16):3224-3230.

    Luznik, L.; Fuchs, E.J. High-dose, post-transplantation cyclophosphamide to promote graft-host tolerance after allogeneic hematopoietic stem cell transplantation. Immunol Res. 2010 Jul;47(1-3):65-77.

    Luznik, L.; Jones, R.J.; Fuchs, E.J. High-dose cyclophosphamide for graft-versus-host disease prevention. Curr Opin Hematol. 2010 Nov;17(6):493-499.

    Petersen, G.M.; Amundadottir, L.; Fuchs, C.S.; Kraft, P.; Stolzenberg-Solomon, R.Z.; Jacobs, K.B.; Arslan, A.A.; Bueno-de-Mesquita, H.B.; Gallinger, S.; Gross, M.; Helzlsouer, K.; Holly, E.A.; Jacobs, E.J.; Klein, A.P.; LaCroix, A.; Li, D.; Mandelson, M.T.; Olson, S.H.; Risch, H.A.; Zheng, W.; Albanes, D.; Bamlet, W.R.; Berg, C.D.; Boutron-Ruault, M.C.; Buring, J.E.; Bracci, P.M.; Canzian, F.; Clipp, S.; Cotterchio, M.; de Andrade, M.; Duell, E.J.; Gaziano, J.M.; Giovannucci, E.L.; Goggins, M.; Hallmans, G.; Hankinson, S.E.; Hassan, M.; Howard, B.; Hunter, D.J.; Hutchinson, A.; Jenab, M.; Kaaks, R.; Kooperberg, C.; Krogh, V.; Kurtz, R.C.; Lynch, S.M.; McWilliams, R.R.; Mendelsohn, J.B.; Michaud, D.S.; Parikh, H.; Patel, A.V.; Peeters, P.H.; Rajkovic, A.; Riboli, E.; Rodriguez, L.; Seminara, D.; Shu, X.O.; Thomas, G.; Tjonneland, A.; Tobias, G.S.; Trichopoulos, D.; Van Den Eeden, S.K.; Virtamo, J.; Wactawski-Wende, J.; Wang, Z.; Wolpin, B.M.; Yu, H.; Yu, K.; Zeleniuch-Jacquotte, A.; Fraumeni, J.F., Jr.; Hoover, R.N.; Hartge, P.; Chanock, S.J. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010 Mar;42(3):224-228.

    Sidana, A.; Chowdhury, W.H.; Fuchs, E.J.; Rodriguez, R. Cryoimmunotherapy in urologic oncology. Urology. 2010 May;75(5):1009-1014.

    Symons, H.J.; Leffell, M.S.; Rossiter, N.D.; Zahurak, M.; Jones, R.J.; Fuchs, E.J. Improved survival with inhibitory killer immunoglobulin receptor (KIR) gene mismatches and KIR haplotype B donors after nonmyeloablative, HLA-haploidentical bone marrow transplantation. Biol Blood Marrow Transplant. 2010 Apr;16(4):533-542.

    Wolpin, B.M.; Kraft, P.; Xu, M.; Steplowski, E.; Olsson, M.L.; Arslan, A.A.; Bueno-de-Mesquita, H.B.; Gross, M.; Helzlsouer, K.; Jacobs, E.J.; LaCroix, A.; Petersen, G.; Stolzenberg-Solomon, R.Z.; Zheng, W.; Albanes, D.; Allen, N.E.; Amundadottir, L.; Austin, M.A.; Boutron-Ruault, M.C.; Buring, J.E.; Canzian, F.; Chanock, S.J.; Gaziano, J.M.; Giovannucci, E.L.; Hallmans, G.; Hankinson, S.E.; Hoover, R.N.; Hunter, D.J.; Hutchinson, A.; Jacobs, K.B.; Kooperberg, C.; Mendelsohn, J.B.; Michaud, D.S.; Overvad, K.; Patel, A.V.; Sanchez, M.J.; Sansbury, L.; Shu, X.O.; Slimani, N.; Tobias, G.S.; Trichopoulos, D.; Vineis, P.; Visvanathan, K.; Virtamo, J.; Wactawski-Wende, J.; Watters, J.; Yu, K.; Zeleniuch-Jacquotte, A.; Hartge, P.; Fuchs, C.S. Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium. Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3140-3149.

Locations

  1. Sidney Kimmel Comprehensive Cancer Center
    • 401 North Broadway Street, Weinberg BLDG, Baltimore, MD 21287

    Expertise

    Education

    Johns Hopkins University School of Medicine

    Fellowship, 1994

    Johns Hopkins University School of Medicine

    Residency, 1988

    University of Pennsylvania Perelman School of Medicine

    Medical Education, MD, 1985

    Board Certifications

    Internal Medicine

    American Board of Internal Medicine, 1988

    Insurance

    Johns Hopkins providers accept various commercial health insurance plans. However, they may not be included in all of an insurance company's plans or offerings. This may include Exchange, Medicaid, Medicare, and specific limited benefit plans. Exceptions to participation also exist based on your employer’s benefits package and the provider's location or specialty. Please contact your insurer directly to make sure your doctor is covered by your plan. For more details, please review our Insurance Information.
    Search plans
    • Aetna
    • CareFirst
    • Cigna
    • First Health
    • Geisinger Health Plan
    • HealthSmart/Accel
    • Humana
    • Johns Hopkins Health Plans
    • MultiPlan
    • Pennsylvania's Preferred Health Networks (PPHN)
    • Point Comfort Underwriters
    • Private Healthcare Systems (PHCS)
    • UnitedHealthcare
    • Veteran Affairs Community Care Network (Optum-VACCN)

    Ratings & Reviews

    4.9 out of 5

    74 ratings, 28 reviews

    The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

    Overall Rating by Patient
    Average provider Overall Rating by Patient rating 4.9 out of 5 stars
    Provider Listened Carefully
    Average provider Provider Listened Carefully rating 4.9 out of 5 stars
    Provider Explained Things Clearly
    Average provider Provider Explained Things Clearly rating 4.9 out of 5 stars
    Provider Knew Medical History
    Average provider Provider Knew Medical History rating 4.9 out of 5 stars
    Provider Showed Respect
    Average provider Provider Showed Respect rating 5 out of 5 stars
    Provider Spent Enough Time
    Average provider Provider Spent Enough Time rating 4.9 out of 5 stars
    Search reviews
      5 out of 5 stars
      Reviewed on 1/16/2025

      Amazing doctor

      5 out of 5 stars
      Reviewed on 12/19/2024

      Excellent great

      5 out of 5 stars
      Reviewed on 12/3/2024

      Love Dr Fuchs..knowledgeable, easy to talk to, answered all my questions, desire to help.

      5 out of 5 stars
      Reviewed on 11/12/2024

      Very pleased with Dr. Fuchs.

      5 out of 5 stars
      Reviewed on 11/7/2024

      The very professional that they take care all the problems so I think recommend all them

      5 out of 5 stars
      Reviewed on 10/29/2024

      Thoughtful,interested.i

      5 out of 5 stars
      Reviewed on 9/19/2024

      This was my first visit with the provider. I really enjoyed the visit. I look forward to seeing them again.

      5 out of 5 stars
      Reviewed on 9/19/2024

      Dr. Fuchs is a very good doctor who takes his time and explains things thoroughly. I was never rushed.

      5 out of 5 stars
      Reviewed on 9/17/2024

      We had a good level of interaction about lab results.

      5 out of 5 stars
      Reviewed on 9/17/2024

      Dr. Fuchs is very professional, thorough and personable. He encourages a feeling of confidence.

      5 out of 5 stars
      Reviewed on 9/10/2024

      Dr Fuchs is a kind, personable and informative Doctor. I never feel rushed at my appointment and he is focused entirely on my questions and health. I feel safe under his care should my condition progress.

      5 out of 5 stars
      Reviewed on 9/10/2024

      Dr. Fuchs is concerned about my well being and an excellent physician

      5 out of 5 stars
      Reviewed on 8/29/2024

      Very good provider. That's why I'm still here

      5 out of 5 stars
      Reviewed on 8/8/2024

      Very attentive and caring.

      5 out of 5 stars
      Reviewed on 7/25/2024

      Excellent communication and listening skills. Easy to work with and makes things easy.

      5 out of 5 stars
      Reviewed on 5/28/2024

      DR. Fuchs is very knowledgeable. He walked through the diagnosis, explaining things as he went. He exhibited positivity and hope for the available treatment regiment.

      5 out of 5 stars
      Reviewed on 5/21/2024

      Dr. Fuchs was very informative and spent quite a bit of time explaining why treatment is not always the best option for my condition. He took the time to walk me through the decision tree that the National Comprehensive Cancer Network created for my condition. It was a very good discussion and he patiently answered all of my questions/concerns. I was very relieved to have an honest and straightforward discussion with a knowledgable provider.

      5 out of 5 stars
      Reviewed on 5/16/2024

      Dr Fuchs has provided me with excellent care for my situation. He's extremely helpful and knowledgeable. Can't thank him enough for his great bedside manner and positive attitude towards me. His awareness of what was needed for me was on point. I really appreciate him helping me through a difficult time.

      5 out of 5 stars
      Reviewed on 5/16/2024

      Dr. Fuchs is an amazing doctor. He is exceptionally helpful, thoughtful, and compassionate

      5 out of 5 stars
      Reviewed on 4/4/2024

      Explained everything to me in terms I could understand. I felt very comfortable with the Dr.

      5 out of 5 stars
      Reviewed on 3/28/2024

      Great Doctor

      5 out of 5 stars
      Reviewed on 3/28/2024

      Told his prognosis in a way that was understandable

      5 out of 5 stars
      Reviewed on 3/21/2024

      Excellent in all ways

      5 out of 5 stars
      Reviewed on 3/19/2024

      Courteous, knowledgeable and perceptive

      5 out of 5 stars
      Reviewed on 3/14/2024

      Everyone was professional

      5 out of 5 stars
      Reviewed on 3/5/2024

      Doctor Fuchs was amazing he explained everything in great detail and spent a good amount of time answering questions from both me and my wife until we felt satisfied that we understood the situation.

      5 out of 5 stars
      Reviewed on 2/22/2024

      Dr Fuchs is very knowledgeable and personable. He always puts my mind at ease regarding my diagnosis and answers all of my many questions. I feel safe under his care. He also is never rushed and spends a lot of time with us.

      5 out of 5 stars
      Reviewed on 2/20/2024

      Dr. Fuchs Is a Wonderful provider