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Ephraim J. Fuchs, MD
Hematologic Malignancy
- Johns Hopkins School of Medicine Faculty
About Ephraim J. Fuchs
Primary Academic Title
Professor of Oncology
Centers and Institutes
Clinical Trial Keywords
bone marrow transplant; lymphoma; leukemia
Research Interests
bone marrow transplant, myeloid disorders
Selected Publications
- Durakovic, N.; Bezak, K.B.; Skarica, M.; Radojcic, V.; Fuchs, E.J.; Murphy, G.F.; Luznik, L. Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions. J Immunol. 2006 Oct 1;177(7):4414-4425.
Huff, C.A.; Fuchs, E.J.; Smith, B.D.; Blackford, A.; Garrett-Mayer, E.; Brodsky, R.A.; Flinn, I.W.; Ambinder, R.F.; Borrello, I.M.; Matsui, W.H.; Vogelsang, G.B.; Griffin, C.A.; Luznik, L.; Jones, R.J. Graft-versus-host reactions and the effectiveness of donor lymphocyte infusions. Biol Blood Marrow Transplant. 2006 Apr;12(4):414-421.
Ravi, R.; Fuchs, E.J.; Jain, A.; Pham, V.; Yoshimura, K.; Prouser, T.; Jalla, S.; Zhou, X.; Garrett-Mayer, E.; Kaufmann, S.H.; Schulick, R.D.; Pardoll, D.M.; Bedi, A. Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling. Cancer Res. 2006 Feb 1;66(3):1730-1739.
Wu, K.; Giovannucci, E.; Byrne, C.; Platz, E.A.; Fuchs, C.; Willett, W.C.; Sinha, R. Meat mutagens and risk of distal colon adenoma in a cohort of U.S. men. Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1120-1125.
Bolanos-Meade, J.; Garrett-Mayer, E.; Luznik, L.; Anders, V.; Webb, J.; Fuchs, E.J.; Huff, C.A.; Matsui, W.; Borrello, I.M.; Brodsky, R.; Kasamon, Y.L.; Swinnen, L.J.; Flinn, I.W.; Ambinder, R.F.; Jones, R.J.; Hess, A.D.; Vogelsang, G.B. Induction of autologous graft-versus-host disease: results of a randomized prospective clinical trial in patients with poor risk lymphoma. Biol Blood Marrow Transplant. 2007 Oct;13(10):1185-1191.
Durakovic, N.; Radojcic, V.; Skarica, M.; Bezak, K.B.; Powell, J.D.; Fuchs, E.J.; Luznik, L. Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse. Blood. 2007 May 15;109(10):4564-4574.
Fuchs, E.J.; Lee, L.A.; Torbenson, M.S.; Parsons, T.L.; Bakshi, R.P.; Guidos, A.M.; Wahl, R.L.; Hendrix, C.W. Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission. J Infect Dis. 2007 Mar 1;195(5):703-710.
Thimmulappa, R.K.; Fuchs, R.J.; Malhotra, D.; Scollick, C.; Traore, K.; Bream, J.H.; Trush, M.A.; Liby, K.T.; Sporn, M.B.; Kensler, T.W.; Biswal, S. Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxid Redox Signal. 2007 Nov;9(11):1963-1970.
Brodsky, R.A.; Luznik, L.; Bolanos-Meade, J.; Leffell, M.S.; Jones, R.J.; Fuchs, E.J. Reduced intensity HLA-haploidentical BMT with post transplantation cyclophosphamide in nonmalignant hematologic diseases. Bone Marrow Transplant. 2008 Oct;42(8):523-527.
Luznik, L.; O''Donnell, P.V.; Symons, H.J.; Chen, A.R.; Leffell, M.S.; Zahurak, M.; Gooley, T.A.; Piantadosi, S.; Kaup, M.; Ambinder, R.F.; Huff, C.A.; Matsui, W.; Bolanos-Meade, J.; Borrello, I.; Powell, J.D.; Harrington, E.; Warnock, S.; Flowers, M.; Brodsky, R.A.; Sandmaier, B.M.; Storb, R.F.; Jones, R.J.; Fuchs, E.J. HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant. 2008 Jun;14(6):641-650.
Symons, H.J.; Levy, M.Y.; Wang, J.; Zhou, X.; Zhou, G.; Cohen, S.E.; Luznik, L.; Levitsky, H.I.; Fuchs, E.J. The allogeneic effect revisited: exogenous help for endogenous, tumor-specific T cells. Biol Blood Marrow Transplant. 2008 May;14(5):499-509.
Warlick, E.D.; O''Donnell, P.V.; Borowitz, M.; Grupka, N.; Decloe, L.; Garrett-Mayer, E.; Borrello, I.; Brodsky, R.; Fuchs, E.; Huff, C.A.; Luznik, L.; Matsui, W.; Ambinder, R.; Jones, R.J.; Douglas Smith, B. Myeloablative allogeneic bone marrow transplant using T cell depleted allografts followed by post-transplant GM-CSF in high-risk myelodysplastic syndromes. Leuk Res. 2008 Sep;32(9):1439-1447.
Bolanos-Meade, J.; Luznik, L.; Muth, M.; Matsui, W.H.; Huff, C.A.; Smith, B.D.; Levy, M.Y.; Kasamon, Y.L.; Swinnen, L.J.; Powell, J.D.; Brodsky, R.A.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Salvage transplantation for allograft failure using fludarabine and alemtuzumab as conditioning regimen. Bone Marrow Transplant. 2009 Mar;43(6):477-480.
Fuchs, E.J.; Huang, X.J.; Miller, J.S. HLA-haploidentical stem cell transplantation for hematologic malignancies. Biol Blood Marrow Transplant. 2009 Nov 2.
Fuchs, E.J.; Luznik, L.; Bolanos-Meade, J.; Miller, C.B.; Brodsky, R.A.; Ambinder, R.F.; Jones, R.J. Successful pregnancy and childbirth after reduced-intensity conditioning and partially HLA-mismatched BMT. Bone Marrow Transplant. 2009 Jun;43(12):969-970.
Kasamon, Y.L.; Luznik, L.; Leffell, M.S.; Kowalski, J.; Tsai, H.L.; Bolanos-Meade, J.; Morris, L.E.; Crilley, P.A.; O''Donnell, P.V.; Rossiter, N.; Huff, C.A.; Brodsky, R.A.; Matsui, W.H.; Swinnen, L.J.; Borrello, I.; Powell, J.D.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Nonmyeloablative HLA-Haploidentical BMT with High-Dose Posttransplantation Cyclophosphamide: Effect of HLA Disparity on Outcome. Biol Blood Marrow Transplant. 2009 Nov 16.
Leffell, M.S.; Cao, K.; Coppage, M.; Hansen, J.A.; Hart, J.M.; Pereira, N.; Pereira, S.; Reinsmoen, N.L.; Senitzer, D.; Smith, A.; Torres, M.; Vega, R.; Fuchs, E. Incidence of humoral sensitization in HLA partially mismatched hematopoietic stem cell transplantation. Tissue Antigens. 2009 Oct 4;74:494-498.
Levy, M.Y.; Sidana, A.; Chowdhury, W.H.; Solomon, S.B.; Drake, C.G.; Rodriguez, R.; Fuchs, E.J. Cyclophosphamide unmasks an antimetastatic effect of local tumor cryoablation. J Pharmacol Exp Ther. 2009 Aug;330(2):596-601.
Oster, S.F.; Ebrahimi, K.B.; Eberhart, C.G.; Schein, O.D.; Stark, W.J.; Jun, A.S. A clinicopathologic series of primary graft failure after Descemet''s stripping and automated endothelial keratoplasty. Ophthalmology. 2009 Apr;116(4):609-614.
Wu, K.; Platz, E.A.; Willett, W.C.; Fuchs, C.S.; Selhub, J.; Rosner, B.A.; Hunter, D.J.; Giovannucci, E. A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma. The American journal of clinical nutrition. 2009 Dec;90(6):1623-1631.
Bolanos-Meade, J.; Smith, B.D.; Gore, S.D.; McDevitt, M.A.; Luznik, L.; Fuchs, E.J.; Jones, R.J. 5-Azacytidine as Salvage Treatment in Relapsed Myeloid Tumors after Allogeneic Bone Marrow Transplantation. Biol Blood Marrow Transplant. 2010 Oct 15;In Press.
Brodsky, R.A.; Chen, A.R.; Dorr, D.; Fuchs, E.J.; Huff, C.A.; Luznik, L.; Smith, B.D.; Matsui, W.H.; Goodman, S.N.; Ambinder, R.F.; Jones, R.J. High-dose cyclophosphamide for severe aplastic anemia: long-term follow-up. Blood. 2010 Mar 18;115(11):2136-2141.
Chen, J.; Garner, R.C.; Lee, L.S.; Seymour, M.; Fuchs, E.J.; Hubbard, W.C.; Parsons, T.L.; Pakes, G.E.; Fletcher, C.V.; Flexner, C. Accelerator mass spectrometry measurement of intracellular concentrations of active drug metabolites in human target cells in vivo. Clin Pharmacol Ther. 2010 Dec;88(6):796-800.
Dezern, A.E.; Luznik, L.; Fuchs, E.J.; Jones, R.J.; Brodsky, R.A. Post-transplantation cyclophosphamide for GVHD prophylaxis in severe aplastic anemia. Bone Marrow Transplant. 2010 Sep 13.
Engler, C.; Kelliher, C.; Spitze, A.R.; Speck, C.L.; Eberhart, C.G.; Jun, A.S. Unfolded protein response in fuchs endothelial corneal dystrophy: a unifying pathogenic pathway? Am J Ophthalmol. 2010 Feb;149(2):194-202 e192.
Engstrom, P.F.; Arnoletti, J.P.; Benson, A.B., 3rd; Berlin, J.D.; Berry, J.M.; Chen, Y.J.; Choti, M.A.; Cooper, H.S.; Dilawari, R.A.; Early, D.S.; Enzinger, P.C.; Fakih, M.G.; Fleshman, J., Jr.; Fuchs, C.; Grem, J.L.; Knol, J.A.; Leong, L.A.; Lin, E.; Mulcahy, M.F.; Rohren, E.; Ryan, D.P.; Saltz, L.; Shibata, D.; Skibber, J.M.; Small, W.; Sofocleous, C.; Thomas, J.; Venook, A.P.; Willett, C. NCCN clinical practice guidelines in oncology. Anal carcinoma. J Natl Compr Canc Netw. 2010 Jan;8(1):106-120.
Fuchs, E.J.; Huang, X.J.; Miller, J.S. HLA-haploidentical stem cell transplantation for hematologic malignancies. Biol Blood Marrow Transplant. 2010 Jan;16(1 Suppl):S57-63.
Kasamon, Y.L.; Jones, R.J.; Brodsky, R.A.; Fuchs, E.J.; Matsui, W.; Luznik, L.; Powell, J.D.; Blackford, A.L.; Goodrich, A.; Gocke, C.D.; Abrams, R.A.; Ambinder, R.F.; Flinn, I.W. Immunologic recovery following autologous stem-cell transplantation with pre- and posttransplantation rituximab for low-grade or mantle cell lymphoma. Ann Oncol. 2010 Jun;21(6):1203-1210.
Kasamon, Y.L.; Luznik, L.; Leffell, M.S.; Kowalski, J.; Tsai, H.L.; Bolanos-Meade, J.; Morris, L.E.; Crilley, P.A.; O''Donnell, P.V.; Rossiter, N.; Huff, C.A.; Brodsky, R.A.; Matsui, W.H.; Swinnen, L.J.; Borrello, I.; Powell, J.D.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Nonmyeloablative HLA-haploidentical bone marrow transplantation with high-dose posttransplantation cyclophosphamide: effect of HLA disparity on outcome. Biol Blood Marrow Transplant. 2010 Apr;16(4):482-489.
Luznik, L.; Bolanos-Meade, J.; Zahurak, M.; Chen, A.R.; Smith, B.D.; Brodsky, R.; Huff, C.A.; Borrello, I.; Matsui, W.; Powell, J.D.; Kasamon, Y.; Goodman, S.N.; Hess, A.; Levitsky, H.I.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease. Blood. 2010 Apr 22;115(16):3224-3230.
Luznik, L.; Fuchs, E.J. High-dose, post-transplantation cyclophosphamide to promote graft-host tolerance after allogeneic hematopoietic stem cell transplantation. Immunol Res. 2010 Jul;47(1-3):65-77.
Luznik, L.; Jones, R.J.; Fuchs, E.J. High-dose cyclophosphamide for graft-versus-host disease prevention. Curr Opin Hematol. 2010 Nov;17(6):493-499.
Petersen, G.M.; Amundadottir, L.; Fuchs, C.S.; Kraft, P.; Stolzenberg-Solomon, R.Z.; Jacobs, K.B.; Arslan, A.A.; Bueno-de-Mesquita, H.B.; Gallinger, S.; Gross, M.; Helzlsouer, K.; Holly, E.A.; Jacobs, E.J.; Klein, A.P.; LaCroix, A.; Li, D.; Mandelson, M.T.; Olson, S.H.; Risch, H.A.; Zheng, W.; Albanes, D.; Bamlet, W.R.; Berg, C.D.; Boutron-Ruault, M.C.; Buring, J.E.; Bracci, P.M.; Canzian, F.; Clipp, S.; Cotterchio, M.; de Andrade, M.; Duell, E.J.; Gaziano, J.M.; Giovannucci, E.L.; Goggins, M.; Hallmans, G.; Hankinson, S.E.; Hassan, M.; Howard, B.; Hunter, D.J.; Hutchinson, A.; Jenab, M.; Kaaks, R.; Kooperberg, C.; Krogh, V.; Kurtz, R.C.; Lynch, S.M.; McWilliams, R.R.; Mendelsohn, J.B.; Michaud, D.S.; Parikh, H.; Patel, A.V.; Peeters, P.H.; Rajkovic, A.; Riboli, E.; Rodriguez, L.; Seminara, D.; Shu, X.O.; Thomas, G.; Tjonneland, A.; Tobias, G.S.; Trichopoulos, D.; Van Den Eeden, S.K.; Virtamo, J.; Wactawski-Wende, J.; Wang, Z.; Wolpin, B.M.; Yu, H.; Yu, K.; Zeleniuch-Jacquotte, A.; Fraumeni, J.F., Jr.; Hoover, R.N.; Hartge, P.; Chanock, S.J. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010 Mar;42(3):224-228.
Sidana, A.; Chowdhury, W.H.; Fuchs, E.J.; Rodriguez, R. Cryoimmunotherapy in urologic oncology. Urology. 2010 May;75(5):1009-1014.
Symons, H.J.; Leffell, M.S.; Rossiter, N.D.; Zahurak, M.; Jones, R.J.; Fuchs, E.J. Improved survival with inhibitory killer immunoglobulin receptor (KIR) gene mismatches and KIR haplotype B donors after nonmyeloablative, HLA-haploidentical bone marrow transplantation. Biol Blood Marrow Transplant. 2010 Apr;16(4):533-542.
Wolpin, B.M.; Kraft, P.; Xu, M.; Steplowski, E.; Olsson, M.L.; Arslan, A.A.; Bueno-de-Mesquita, H.B.; Gross, M.; Helzlsouer, K.; Jacobs, E.J.; LaCroix, A.; Petersen, G.; Stolzenberg-Solomon, R.Z.; Zheng, W.; Albanes, D.; Allen, N.E.; Amundadottir, L.; Austin, M.A.; Boutron-Ruault, M.C.; Buring, J.E.; Canzian, F.; Chanock, S.J.; Gaziano, J.M.; Giovannucci, E.L.; Hallmans, G.; Hankinson, S.E.; Hoover, R.N.; Hunter, D.J.; Hutchinson, A.; Jacobs, K.B.; Kooperberg, C.; Mendelsohn, J.B.; Michaud, D.S.; Overvad, K.; Patel, A.V.; Sanchez, M.J.; Sansbury, L.; Shu, X.O.; Slimani, N.; Tobias, G.S.; Trichopoulos, D.; Vineis, P.; Visvanathan, K.; Virtamo, J.; Wactawski-Wende, J.; Watters, J.; Yu, K.; Zeleniuch-Jacquotte, A.; Hartge, P.; Fuchs, C.S. Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium. Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3140-3149.
Locations
- Sidney Kimmel Comprehensive Cancer Center
- 401 North Broadway Street, Weinberg BLDG, Baltimore, MD 21287
- phone: 410-955-8964
- fax: 410-367-2194
Expertise
Education
Johns Hopkins University School of Medicine
Fellowship, 1994Johns Hopkins University School of Medicine
Residency, 1988University of Pennsylvania Perelman School of Medicine
Medical Education, MD, 1985Board Certifications
Internal Medicine
American Board of Internal Medicine, 1988Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)
Ratings & Reviews
4.9 out of 5
74 ratings, 28 reviewsThe Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
- 5 out of 5 starsReviewed on 1/16/2025
Amazing doctor
- 5 out of 5 starsReviewed on 12/19/2024
Excellent great
- 5 out of 5 starsReviewed on 12/3/2024
Love Dr Fuchs..knowledgeable, easy to talk to, answered all my questions, desire to help.
- 5 out of 5 starsReviewed on 11/12/2024
Very pleased with Dr. Fuchs.
- 5 out of 5 starsReviewed on 11/7/2024
The very professional that they take care all the problems so I think recommend all them
- 5 out of 5 starsReviewed on 10/29/2024
Thoughtful,interested.i
- 5 out of 5 starsReviewed on 9/19/2024
This was my first visit with the provider. I really enjoyed the visit. I look forward to seeing them again.
- 5 out of 5 starsReviewed on 9/19/2024
Dr. Fuchs is a very good doctor who takes his time and explains things thoroughly. I was never rushed.
- 5 out of 5 starsReviewed on 9/17/2024
We had a good level of interaction about lab results.
- 5 out of 5 starsReviewed on 9/17/2024
Dr. Fuchs is very professional, thorough and personable. He encourages a feeling of confidence.
- 5 out of 5 starsReviewed on 9/10/2024
Dr Fuchs is a kind, personable and informative Doctor. I never feel rushed at my appointment and he is focused entirely on my questions and health. I feel safe under his care should my condition progress.
- 5 out of 5 starsReviewed on 9/10/2024
Dr. Fuchs is concerned about my well being and an excellent physician
- 5 out of 5 starsReviewed on 8/29/2024
Very good provider. That's why I'm still here
- 5 out of 5 starsReviewed on 8/8/2024
Very attentive and caring.
- 5 out of 5 starsReviewed on 7/25/2024
Excellent communication and listening skills. Easy to work with and makes things easy.
- 5 out of 5 starsReviewed on 5/28/2024
DR. Fuchs is very knowledgeable. He walked through the diagnosis, explaining things as he went. He exhibited positivity and hope for the available treatment regiment.
- 5 out of 5 starsReviewed on 5/21/2024
Dr. Fuchs was very informative and spent quite a bit of time explaining why treatment is not always the best option for my condition. He took the time to walk me through the decision tree that the National Comprehensive Cancer Network created for my condition. It was a very good discussion and he patiently answered all of my questions/concerns. I was very relieved to have an honest and straightforward discussion with a knowledgable provider.
- 5 out of 5 starsReviewed on 5/16/2024
Dr Fuchs has provided me with excellent care for my situation. He's extremely helpful and knowledgeable. Can't thank him enough for his great bedside manner and positive attitude towards me. His awareness of what was needed for me was on point. I really appreciate him helping me through a difficult time.
- 5 out of 5 starsReviewed on 5/16/2024
Dr. Fuchs is an amazing doctor. He is exceptionally helpful, thoughtful, and compassionate
- 5 out of 5 starsReviewed on 4/4/2024
Explained everything to me in terms I could understand. I felt very comfortable with the Dr.
- 5 out of 5 starsReviewed on 3/28/2024
Great Doctor
- 5 out of 5 starsReviewed on 3/28/2024
Told his prognosis in a way that was understandable
- 5 out of 5 starsReviewed on 3/21/2024
Excellent in all ways
- 5 out of 5 starsReviewed on 3/19/2024
Courteous, knowledgeable and perceptive
- 5 out of 5 starsReviewed on 3/14/2024
Everyone was professional
- 5 out of 5 starsReviewed on 3/5/2024
Doctor Fuchs was amazing he explained everything in great detail and spent a good amount of time answering questions from both me and my wife until we felt satisfied that we understood the situation.
- 5 out of 5 starsReviewed on 2/22/2024
Dr Fuchs is very knowledgeable and personable. He always puts my mind at ease regarding my diagnosis and answers all of my many questions. I feel safe under his care. He also is never rushed and spends a lot of time with us.
- 5 out of 5 starsReviewed on 2/20/2024
Dr. Fuchs Is a Wonderful provider