Daniel Yeong-Jin Song, MD

Professional Titles

• Co-Director, Prostate Cancer Multidisciplinary Clinic

Primary Academic Title

Professor of Radiation Oncology and Molecular Radiation Sciences

Background

Centers and Institutes

• Johns Hopkins Greenberg Bladder Cancer Institute
• Sidney Kimmel Comprehensive Cancer Center

Clinical Trial Keywords

Prostate brachytherapy; Hypofractionated radiotherapy

Videos

• Meet our Expert: Dr. Danny Song

• Treating Prostate Cancer with Radiation Therapy - Dr Daniel Song

Additional Academic Titles

Professor of Urology, Professor of Oncology

Research Summary

Dr. Song's research focuses on developting an improved seed visualization method for prostate brachytherapy.  His research is currently funded by the National Cancer Institute, and he is working in collaboration with scientists from the Johns Hopkins Engineering Research Center.

Dr. Song's research interests include the development and refinement of new imaging methods to improve radiation targeting, as well as innovative means of reducing potential side effects of radiation treatment.  His research efforts have been sponsored and funded by competitive grants from organizations such as the Department of Defense, the National Cancer Institute, and the American Cancer Society.

PubMed

http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=Song%20DY

Selected Publications

• Alcorn S, Walker AJ, Gandhi N, Narang A, Wild AT, Hales RK, Herman JM, Song DY, DeWeese TL, Antonarakis ES, Tran PT: Molecularly targeted agents as radiosensitizers in cancer therapy--focus on prostate cancer.  Int J Mol Sci. 2013;Jul 16;14(7):14800-14832. doi: 10.3390/ijms140714800.  PMC3742274 

• Benedict S, Cardinale RM, and Song DY: “Application of IMRT to stereotactic radiosurgery”, in Intensity Modulated Radiotherapy: A Clinical Perspective, Arno J. Mundt and John C. Roeske, eds., BC Decker Inc Publisher, Hamilton, Ontario, Canada, 2004.

• Benedict SH, Yenice KM, Followill D, Galvin JM, Hinson W, Kavanagh B, Keall P, Lovelock M, Meeks S, Papiez L, Purdie T, Sadagopan R, Schell MC, Salter B, Schlesinger DJ, Shiu AS, Solberg T, Song DY, Stieber V, Timmerman R, Tomé WA, Verellen D, Wang L, Yin FF: Stereotactic body radiation therapy: the report of AAPM Task Group 101.  Med Phys. 2010;37:4078-101.

• Christodouleas J, Fox J, Song DY, DeWeese TL: “Radiation Therapy for Prostate Cancer”, in Early Diagnosis of Cancer Series: Prostate Cancer, Su LM (Ed), Saunders Elsevier, Philadelphia, PA, 2009.

• Christodouleas JP, Tang S, Susil RC, McNutt TR, Song DY, Bekelman J, Deville C, Vapiwala N, DeWeese TL, Lu HM, Both S: The effect of anterior proton beams in the setting of a prostate-rectum spacer.  Med Dosim. 2013;38(3):315-319. (Epub 2013 Apr 8)

• Corn PG, Song DY, Heath E, Maier J, Meyn R, Kuban D, DePetrillo TA, Mathew P: Sunitinib plus androgen deprivation and radiation therapy for patients with localized high-risk prostate cancer: results from a multi-institutional phase I study.  Int J Radiat Oncol Biol Phys. 2013;86(3):540-545. PMC4103023.

• Dehghan E, Kuo N, Deguet A, Le Y, Armour E, Burdette EC, Song DY, Fichtinger G, Prince JL, Lee J:  “Ultrasound-Fluoroscopy Registration for Intraoperative Dynamic Dosimetry in Prostate Brachytherapy”, in Abdomen and Thoracic Imaging, El-Baz, Saba, and Suri eds., Springer, 2014. 

• DeWeese TL, Song DY: Current evidence for the role of combined androgen suppression and radiation in the treatment of adenocarcinoma of the prostate. Urology. 2000;55:169-174.

• DeWeese TL, Song DY: Radiation dose escalation as treatment for clinically-localized prostate  cancer: is more really better? JAMA. 2005;294:1274-1275.

• Fichtinger G, Fiene J, Kennedy CW, Kronreif G, Iordachita I, Song DY, Burdette EC, Kazanzides P: Robotic assistance for ultrasound guided prostate brachytherapy.  Med Image Anal. 2008;12(5);535-545.

• Ford EC, Gaudette R, Myers L, Vanderver B, Engineer L, Zellars R, Song DY, Wong J, DeWeese TL: Evaluation of safety in a radiation oncology setting using failure mode and effects analysis.  Int J Radiat Oncol Biol Phys. 2009;74(3):852-858.  PMC3655406

• Gandhi N, Wild AT, Chettiar ST, Aziz K, Kato Y, Gajula RP, Williams RD, Cades JA, Annadanam A, Song D, Zhang Y, Hales RK, Herman JM, Armour E, DeWeese TL, Schaeffer EM, Tran PT: Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells.  Cancer Biol Ther. 2013;14(4):347-356. (Epub 2013 Jan 28)  PMC3667875

• Hales R, Song DY: “Radiation Therapy” in Johns Hopkins Patients’ Guide to Lung Cancer, Klamerus J, Brahmer J, Ettinger D (Eds), Jones and Bartlett, Sudbury, MA.

• Huynh-Le M, Zhang Z, Tran PT, DeWeese TL, Song DY:  Low interrater reliability in grading of rectal bleeding using National Cancer Institute Common Toxicity Criteria and Radiation Therapy Oncology Group toxicity scales: a survey of radiation oncologists. Int J Radiat Oncol Biol Phys. 2014;Dec 1;90(5):1076-1082. doi: 10.1016/j.ijrobp.2014.08.014. (Epub 2014 Oct 13).

• Jain A, Deguet A, Iordachita I, Chintalapani G, Blevins J, Le Y, Armour E, Burdette C, Song D, Fichtinger G: Intra-operative 3D guidance in prostate brachytherapy using a non-isocentric C-arm.  Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2007;10(Pt 2):9-17.

• Jain A, Deguet A, Iordachita I, Chintalapani G, Vikal S, Blevins J, Le Y, Armour E, Burdette C, Song D, Fichtinger G: Intra-operative 3D guidance and edema detection in prostate brachytherapy using a non-isocentric C-arm.  Med Image Anal. 2012;16:731-743.

• Kumar R, Le Y, DeWeese T, Song DY: Re-implantation following sub-optimal dosimetry in low-dose-rate prostate brachytherapy: technique for outpatient source insertion using local anesthesia. J Contemp Brachy (in press).

• Kuo N, Deguet A, Song DY, Burdette EC, Prince JL, Lee J: Automatic segmentation of radiographic fiducial and seeds from fluoroscopic images in prostate brachytherapy.  Med Eng Phys. 2012;34:64-77.  PMC3209498

• Kuo N, Dehghan E, Deguet A, Mian OY, Le Y, Burdette EC, Fichtinger G, Prince JL, Lee J, Song DY: An image-guidance system for dynamic dose calculation in prostate brachytherapy using ultrasound and fluoroscopy.  Med Phys. 2014;41(9):091712. doi: 10.1118/1.4893761.

• Kuo N, Kang HJ, Song DY, Kang JU, Boctor EM: Real-time photoacoustic imaging of prostate brachytherapy seeds using a clinical ultrasound system.  J Biomed Opt. 2012;17(6):066005.

• Lee J, Kuo N, Deguet A, Dehghan E, Song DY, Burdette EC, Prince JL: Intraoperative 3D reconstruction of prostate brachytherapy implants with automatic pose correction.  Phys Med Biol. 2011;56:5011-5027.  PMC3172706

• Lin J, Sinibaldi VJ, Carducci MA, Denmeade S, Song D, DeWeese T, Eisenberger MA: Phase I trial with a combination of docetaxel and (153)Sm-lexidronam in patients with castration-resistant metastatic prostate cancer. Urol Oncol. 2011;29:670-675.  PMC3483074

• Lin SH, Sugar E, Teslow T, McNutt T, Saleh H, Song DY: Comparison of daily couch shifts using MVCT (TomoTherapy) and B-mode Ultrasound (BAT system) during prostate radiotherapy.  Technol Cancer Res Treat. 2008;7(4):279-285. PMC3634324

• Muntener M, Patriciu A, Petrisor D, Schar M, Ursu D, Song DY, Stoianovici D: Transperineal prostate intervention: robot for fully automated MR imaging – system description and proof of principle in a canine model. Radiology. 2008;247(2):543-549.  PMC3108451

• Pinkawa M, Schoth F, Bohmer D, Hatiboglu G, Sharabi A, Song D, Eble MJ: Current standards and future directions for prostate cancer radiation therapy.  Exp Rev Anticancer Ther. 2013;13:75-88

• Podder TK, Beaulieu L, Caldwell B, Cormack RA, Crass JB, Dicker AP, Fenster A, Fichtinger G, Meltsner MA, Moerland MA, Nath R, Rivard MJ, Salcudean T, Song DY, Thomadsen BR, Yu Y: AAPM and GEC-ESTRO guidelines for image-guided robotic brachytherapy: Report of Task Group 192.  Med Phys. 2014 Oct;41(10):101501. doi: 10.1118/1.4895013.

• Qiu H, Herman J, Ahuja N, DeWeese T, Song DY: Neoadjuvant chemoradiation followed by interstitial prostate brachytherapy for synchronous prostate and rectal cancer.  Pract Radiat Oncol. 2012;4:e77-84.

• Sharabi A, Song DY: “Effects on rectal dose of injectable hydrogel spacer”, in Innovative Radiotherapy Techniques for Prostate Cancer, Pinkawa M (Ed), UNI-MED Science (in press).

• Song DY, and DeWeese TL: “Radiotherapy for the treatment of locally advanced and metastatic prostate cancer”, in Prostate Cancer: Surgical Principles and Practice, Kirby, Partin, Feneley, and Parsons eds., Taylor and Francis, London, 2005.

• Song DY, Blomgren H:  “Stereotactic Body Radiotherapy for Lung Tumors” in Stereotactic Body Radiotherapy, Kavanagh and Timmerman, eds., Williams-Wilkins, 2004.

• Song DY, Burdette EC, Fiene J, Armour E, Kronreif G, Deguet A, Zhang Z, Iordachita I, Fichtinger G, Kazanzides P: Robotic needle guide for prostate brachytherapy: clinical testing of feasibility and performance.  Brachytherapy. 2011;10:57-63.  PMC3021094

• Song DY, DeWeese TL: “Radiation Therapy”, in Dr. Patrick Walsh’s Guide to Surviving Prostate Cancer, Janet Worthington and Patrick C. Walsh, Warner Books, NY, 2007.

• Song DY, DeWeese TL: Can PSA nadir predict prostate cancer outcomes following radiotherapy?  Nat Clin Pract Urol. 2006;3:464-465.

• Song DY, DeWeese TL: Defining the appropriate measure of success for adjuvant radiation following prostatectomy.  Nat Clin Pract Urol. 2007;4(8):416-417. Munn DH, Beall AC, 

• Song DY, Herfarth KK, Uhl M, Eble MJ, Pinkawa M, van Triest B, Kalisvaart R, Weber DC, Miralbell R, DeWeese TL, Ford EC: A multi-institutional clinical trial of rectal dose reduction via injected polyethylene-glycol hydrogel during IMRT for prostate cancer: Analysis of dosimetric outcomes. Int J Radiat Oncol Biol Phys. 2013;87(1):81-87. (Epub 2013 Feb 13)  PMC3737267

• Song DY, Jabbour S, and DeWeese TL: “Emerging concepts in improving the therapeutic outcome of locally advanced prostate cancer using radiation therapy”, in Prostate Cancer: Biology, genetics, and the new therapeutics, Chung, Isaacs, and Simon eds., Humana Press, NJ, 2006.

• Song DY, Jain AK, Zhang Z, Deguet A, Le Y, Armour E, Burdette EC, Fichtinger G: Dynamic intraoperative dosimetry for prostate brachytherapy using a non-isocentric C-arm.  Brachytherapy. 2011;10:98-106.

• Song DY, Kavanagh BD, Benedict SH, Schefter TA: Stereotactic body radiotherapy: rationale, techniques, optimization, and application of an emerging technology. Oncology. 2004;18:1419-1430.

• Song DY, Lawrie WT, Abrams RA, Kafonek DR, Bayless TM, Welsh JS, DeWeese TL:  Acute and late radiotherapy toxicity in patients with inflammatory bowel disease.  Int J Radiat Oncol Biol Phys. 2001;51(2):455-459.

• Song DY, Thompson TL, Ramakrishnan V, Harrison R, Bhavsar N, Onaodowan O, DeWeese TL: Salvage Radiotherapy for Rising or Persistent PSA after Radical Prostatectomy. Urology. 2002;60(2):281-287.

• Song DY.  Stereotactic body radiation therapy: rationale and clinical experience. In: UpToDate.com, Rose BD (Ed), UpToDate, Wellesley, MA, 2008-2013.

• Song DY: “Brachytherapy for Prostate Cancer”, in Radiation Oncology: a Question-Based Review”, Hristov B, Lin S, Christodouleas J (Eds), Lippincott Williams & Wilkins, Philadelphia, PA, 2010.

• Song DY: Oncology scan—rising stars, fading stars, and shooting stars: new trends in prostate cancer management. Int J Radiat Oncol Biol Phys. 2014;89(1):4-6.

• Song DY: The role of radiotherapy in the treatment of locally advanced prostate cancer. Community Oncol. 2006;3:759-764.

• Sundi D, Cohen J, Cole A, Neuman B, Cooper J, Faisal F, Raben M, Song DY, Drake C, Netto G, Macura K, DeWeese T, Partin A, Bivalacqua T, Ross A, Schaeffer E: Establishment of a new prostate cancer multidisciplinary clinic.  Prostate. 2015 75(2):191-9. PMCID: PMC4270998.

• Susil RC, McNutt T, DeWeese TL, Song DY: Effects of prostate-rectum separation on rectal dose from external beam radiation therapy.  Int J Radiat Oncol Biol Phys. 2010;76(4):1251-1258.  PMC3115781

• Swartz MJ, Janson K, DeWeese TL, Song DY. Radiation therapy for prostate cancer: the role for dose escalation.  Compr Ther. 2007;33:216-222.

• Tran PT, Hales RK, Zeng J, Aziz K, Salih T, Gajula RP, Chettiar S, Gandhi N, Wild AT, Kumar R, Herman JM, Song DY, DeWeese TL: Tissue biomarkers for prostate cancer radiation therapy. Curr Mol Med. 2012;12:772-787.

• Uhl M, Herfarth K, Eble MJ, Pinkawa M, van Triest B, Kalisvaart R, Weber DC, Miralbell R, Song DY, DeWeese TL: Absorbable hydrogel spacer use in men undergoing prostate cancer radiotherapy: 12 month toxicity and proctoscopy results of a prospective multicenter phase II trial.  Radiat Oncol. 2014;9:96.  PMC24758224

• Yang Y, Ford EC, Wu B, Pinkawa M, van Triest B, Campbell P, Song DY, McNutt TR: An overlap-volume-histogram based method for rectal dose prediction and automated treatment planning in the external beam prostate radiotherapy following hydrogel injection. Med Phys. 2013;Jan;40(1):011709. doi: 10.1118/1.4769424.

• Yu HH, Song DY, Tsai Y, Thompson T, Frassica DA, DeWeese TL: Perineural invasion affects biochemical recurrence-free survival in patients with prostate cancer treated with definitive external beam radiotherapy.  Urology. 2007;70(1):111-116.

Honors

• National Institutes of Health 2nd Biennial Career Development Award
• Director's Teaching Award, The Sidney Kimmel Comprehensive Cancer Center, 1/1/14
• Educator of the Year Award, Association of Residents in Radiation Oncology, 1/1/10
• Faculty Teaching Award, VCU Department of Radiation Oncology, 1/1/02
• "Best Pediatric Doctors in Richmond,", Richmond magazine, 1/1/02
• Educator of the Year Award, Association of Residents in Radiation Oncology, 1/1/02
• Alpha Omega Alpha Medical Honor Society, 1/1/95

Memberships

• American Brachytherapy Society
• American Society of Radiation Oncology