Cory Brayton, DVM
Highlights
Languages
- English
Gender
FemaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Cory Brayton
Professional Titles
- Director, Phenotyping Core
Primary Academic Title
Associate Professor of Molecular and Comparative Pathobiology
Background
Cory Brayton, DVM, Diplomate ACLAM, Diplomate ACVP, is an associate professor of molecular and comparative pathobiology at the Johns Hopkins University School of Medicine. Her research focuses on phenotyping and pathology in diverse translational research areas, including cancer, aging, immunology, infectious diseases. Dr. Brayton serves as the director of the 'Phenotyping Core' for pathology support and collaborations, and translational animal research expertise at Johns Hopkins.
Dr. Brayton is a diplomate of the American College of Laboratory Animal Medicine (ACLAM), and of the American College of Veterinary Pathologists (ACVP). She served as president of ACVP in 2014.
Dr. Brayton’s expertise includes the spontaneous pathology and genetics of research mice, experimental pathology, and the impacts of infectious and other environmental factors on pathology, disease expression, and other phenotypes in diverse research models.
She received her DVM from Cornell University, and did postdoctoral research and pathology training in New York City at the Animal Medical Center, Cornell University Medical College, and The Rockefeller University. At The Rockefeller University (1989-1992), she became specifically interested in genetically engineered mice (GEM) models in translational research, and in their pathology and characterization (phenotyping).
At the Hospital for Special Surgery (1992-1998), she was attending veterinarian and Director of the Facility for Comparative Studies. At Baylor College of Medicine (1998-2004), she headed the Comparative Pathology Laboratory, and was responsible for health surveillance and diagnostic pathology for a diverse research population including more than 150,000 mice. She also served as attending veterinarian, and associate director of the Center for Comparative Medicine. In 2004, she moved to Johns Hopkins to develop the Phenotyping Core.
Dr. Brayton’s primary teaching interest is to improve and promote understanding of model organism biology and pathology, especially as it is relevant to valid and predictive translational biomedical research. In the US and abroad she has developed, directed, co-directed, and lectured in symposia, conferences, courses and workshops relevant to phenotyping, pathology, genetics of mice and other laboratory animals. She has authored and coauthored books, chapters and invited reviews on mouse biology and pathology.
At JHU, she has developed symposia and courses including 680.712 Phenotyping for Functional Genetics (Mouse Pathobiology and Phenotyping Short Course), and participated as faculty and lecturer in 680.700 One Medicine; 680.701 Principles of Animal Pathology and Genetically Engineered Mice; 680.702 LAM/PATH Integrated Problem Solving; 680.703 Animal Pathology Laboratory; 680.710 Clinical Conference in Laboratory Animal Medicine; 680.711 Comparative Pathology Conference; 680.713 Regulations that Govern Animal Research; 680.714 Systems Pathology of Animals;680.715 Conversations on Research Animal Medicine and Management (CRAMM); 690.707 Experimental Design and Scientific Writing; Toxicological Pathology, Bloomberg School of Public Health, and other courses.
Centers and Institutes
Contact for Research Inquiries
Phone: (410) 502-3050
cbrayton@jhmi.edu
Research Interests
Cancer, Drug Discovery and Development, Experimental Pathology, Genetically Engineered Mice, GLP, Infectious Disease, Phenotyping, Toxicologic Pathology
Lab Website
Phenotyping and Pathology Core - Lab Website
- The Phenotyping Core promotes functional genomics and other preclinical translational science at Johns Hopkins. We assist and collaborate in the characterization and use of genetically and phenotypically relevant animal models of disease and gene function.
Core Facility
Phenotyping (and Pathology) Core (Phenocore)
Research Summary
The Phenotyping Core facilitates interdisciplinary phenotyping and translational research collaborations, and offers preclinical research pathology support and collaboration. Dr. Brayton works with JHU faculty and cores in multidisciplinary research in diverse research areas.
Dr. Brayton’s primary research role, as collaborator and phenotyping core director, is in model selection, study design, data analysis, and pathology to achieve valid and predictive translational biomedical research. Research outcomes (phenotypes) represent the intended and unintended consequences of experimental interventions, as well as often under-recognized nature (genetic) and nurture (environmental) influences on the model system. Dr. Brayton’s expertise includes the spontaneous pathology and genetics of research mice, as well as experimental pathology, and the impacts of infectious and other environmental factors on pathology, disease expression and other phenotypes in diverse species. She has published on comparative cardiovascular, pulmonary, renal, musculoskeletal, hematopoietic, neural and ophthalmic pathology, comparative carcinogenesis, autoimmune diseases and infectious diseases in mice and other species.
Contact her to discuss experimental design, phenotyping, collaboration or research pathology needs.
Selected Publications
Brayton CF, Treuting PM, Ward JM. Pathobiology of Aging Mice and GEM: Background Strains and Experimental Design. Vet Pathol. 2012. 49(1):85-105. PMID 26387837
Cooper TK, Meyerholz DK, Beck AP, Delaney MA, Piersigilli A, Southard TL, Brayton CF.Research Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits. ILAR J. 62(1-2):77-132. PMCID: PMC9291387
Mulka KR, Beck SE, Solis CV, Johanson AL, Queen SE, McCarron ME, Richardson MR, Zhou R, Marinho P, Jedlicka A, Guerrero-Martin S, Shirk EN, Braxton AM, Brockhurst J, Creisher PS, Dhakal S, Brayton CF, Veenhuis RT, Metcalf Pate KA, Karakousis PC, Zahnow CA, Klein SL, Jain SK, Tarwater PM, Pekosz AS, Villano JS, Mankowski JL; Progression and Resolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Golden Syrian Hamsters. Johns Hopkins COVID-19 Hamster Study Group. Am J Pathol. 2022 Feb; PMC8577872
Radaelli E, Santagostino SF, Sellers RS, Brayton CF. (2019). Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research. ILAR J. 59(3):211-246. Review. PMC7114723
Zeiss, CJ and CF Brayton. Immune responses to the real world. (Nature) Lab Anim (NY). 2017. 47(1): 13-14. Editorial
Courses & Syllabi
- Phenotyping for Functional Genetics (Mouse Pathobiology and Phenotyping Short Course), 680.712, 1/1/07
- Comparative Pathology Tuesday slide conference
Honors
- Doctoris Medicinae Veterinariae (Honorary), University of Bern; Switzerland, 12/1/21
- Affiliate Professor (Honorary); Laboratory Animal Pathology,, University of Copenhagen; Denmark, 9/2/20
- Pravin N. Bhatt Scientific Investigator Award and Wallace P. Rowe Lecture, AALAS American Association for Laboratory Science, 10/1/18
- Edgar Hartley Kettle Distinguished Speaker, Royal College of Pathologists, British Society of Toxicological Pathologists, 6/1/16
- President, American College of Veterinary Pathologists (ACVP), 10/1/14
- Robert Ferrell Distinguished Lecturer, Charles Louis Davis Foundation for the Advancement of Veterinary and Comparative Pathology, 10/1/13
- President Elect, American College of Veterinary Pathologists (ACVP), 10/1/13
- Outstanding Leadership, Baylor College of Medicine, 12/1/01
- Outstanding Service, Charles Louis Davis Foundation for the Advancement of Veterinary and Comparative Pathology, 11/1/01
Graduate Program Affiliations
Graduate Program Comparative Pathology in Translational Science
Memberships
- American Association for Laboratory Animal Science (AALAS),
member since 1990; Editorial Board 'JAALAS', 'Comparative Medicine' since 2002.
- American College of Laboratory Animal Medicine (ACLAM),
Diplomate since 1997; Examination Committee 2000-2003.
- American College of Veterinary Pathologists (ACVP),
Diplomate since 1997; Council (elected) 2009-2012; President Elect 2013; President 2014.
- American Veterinary Medical Association, member
- Davis Thompson Foundation for the Advancement of Veterinary and Comparative Pathology,
Board of Directors; Faculty of Discussants since 2000.
- Institute for Laboratory Animal Research ILAR (National Academy of Sciences Division on Earth and Life Studies of the National Research Council),
Councillor since 2012-2018 (ex officio -2022; co Editor in Chief 'ILAR Journal' (2013-2022).
- International Council for Laboratory Animal Science (ICLAS),
US representative since 2014
- International Mammalian Genome Society (IMGS),
Editorial Board, Mammalian Genome, since 2013
- Society of Toxicologic Pathology (STP),
Member since 2006; Program committee 2014, 2016; Editorial board "Toxicologic Pathology' since 2018.
Professional Activities
- American College of Laboratory Animal Medicine, Diplomate, 1/1/97
- American College of Veterinary Pathologists, Diplomate, 1/1/97
- American College of Veterinary Pathologists (ACVP), President, 1/1/14 - 1/1/15