Chloe L. Thio, MD

Primary Academic Title

Professor of Medicine

Background

Centers and Institutes

• Infectious Disease Center for Viral Hepatitis
• Infectious Diseases Center for Viral Hepatitis Research

Contact for Research Inquiries

855 N Wolfe Street
Room 533
Baltimore, MD 21205

Phone: (410) 614-6088
cthio@jhmi.edu

Research Interests

Hepatitis B, hepatitis C, HIV

Lab Website

Chloe Thio Lab

• Research in the Chloe Thio lab focuses on several areas. First, HBV virology and immunology in HBV monoinfected and HIV-HBV co-infected individuals that will ultimately help develop a cure for HBV. Second, HCV infection in men who have sex with men. Third, non-alcoholic fatty liver disease with a focus on HIV-infected individuals. Fourth, host genetic determinants of spontaneous HBV recovery and HCV clearance.

Research Summary

Dr. Thio has several research interests. Her laboratory is focused on hepatitis B translational science that is working towards a hepatitis B cure including HBV virology in single hepatocytes, immune response to acute hepatitis B, and neutralizing antibodies to hepatitis B.

Her laboratory also investigates the human genetic determinants of HBV and HCV clearance, where she examines polymorphisms in human genes in persons that have either recovered from or have a persistent viral hepatitis infection.

Her laboratory also studies fatty liver in people with HIV and HIV-hepatitis co-infection.

Selected Publications

• Balagopal A, Grudda T, Ribeiro RM, Saad YS, Hwang HS, Quinn J, Murphy M, Ward K, Sterling RK, Zhang Y, Perelson AS, Sulkowski MS, Osburn WO, Thio CL. Single hepatocytes show persistence and transcriptional inactivity of hepatitis B. JCI Insight 2020 Oct 5(19): 140584

• Falade-Nwulia O, Seaberg EC, Snider AE, Rinaldo CR, Wolinsky SM, Witt MD, Thio CL. Outcomes of acute hepatitis B virus (HBV) in HIV infection with and without HBV-active antiretroviral therapy. AIDS 2021 May; 35(6): 991-993

• Irvin R, Gamble T, Malone J, Wang Z, Wilson E, Hughes JP, Farley J, Mayer KH, Del Rio C, Batey DS, Cummings V, Remien RH, Beyrer C, Thio CL. HTPN 078: High prevalence of HCV antibodies among urban US men who have sex with men (MSM) independent of HIV status. CID, 2021 Oct 73(7):e2205-2210

• Price JC, Wang R, Seaberg EC, Brown TT, Budoff MJ, Kingley LA, Palella, FJ, Witt MD, Post WS, Lake JE, Thio CL. Sex hormone binding globulin levels are inversely associated with nonalcoholic fatty liver disease in HIV-infected and –uninfected men. OFID 2019 December,:6(12):ofz468. PMC7047947

• Stevens KE, Thio CL, Osburn WO. CCR5 deficiency enhances hepatic innate immune cell recruitment & inflammation in a murine model of acute hepatitis B infection. Immun Cell Biol 2019 Mar, 97(3):317-25

Graduate Program Affiliations

• Molecular Microbiology and Immunology

  Pathobiology

Memberships

• American College of Physicians
• American Society of Clinical Investigation
• HIVMA
• Infectious Diseases Society of America
• American Association for the Study of Liver Disease

Professional Activities

Johns Hopkins Department of Medicine, Promotions Committee, 1/1/15 - 6/30/20