Charles G. Eberhart, MD, PhD

Professional Titles

• Director, Neuropathology and Ophthalmic Pathology
• Charlotte Wilson and Margaret Whitener Professor of Ophthalmology

Primary Academic Title

Professor of Pathology

Background

Centers and Institutes

Sidney Kimmel Comprehensive Cancer Center

Videos

• Dr. Charles Eberhart | Ophthalmic Pathology

Additional Academic Titles

Professor of Ophthalmology, Professor of Oncology

Lab Website

Eberhart, Rodriguez and Raabe Lab - Lab Website

• Dr. Eberhart works closely with Drs.Rodriguez and Raabe in a multidisciplinary research group. Their studies use our understanding of normal development to guide investigation of the neoplastic process. They have implicated Hedgehog, Notch and other developmentally significant signaling cascades in the initiation and ongoing growth of brain tumors. They are also engaged in preclinical testing of pharmacological agents that target multiple pathways in brain and eye tumors. To accomplish this they have generated new tumor models from surgical specimens and by making relevant oncogenic changes in progenitor cells. A related area of interest in the lab is the relationship between stem cells and cancer. The possibility that specific types of transformed stem cells represent the origins of brain and eye tumors, as well as the hypothesis that “cancer stem cells” are required for long-term tumor self renewal and growth, are both active areas of investigation.

Research Summary

Dr. Eberhart and his lab members study the molecular genetics of medulloblastoma, low grade glioma, glioblastoma, uveal melanoma and other tumors of the brain and eye. One major focus is on Notch and other pathways which play a key role in both normal development and in neoplasia. They are currently analyzing the long terms effects of Notch blockade on cancer stem cells in brain and eye tumors, how therapeutic resistance emerges, and the basis of the sometimes antagonistic effects of various Notch receptors. They are also examining the role of c-Myc in the stem cell phenotype of cancer. Identifying novel genetic changes in ocular surface tumors and other poorly understood neoplasms represents another focus.

Google Scholar

https://scholar.google.com/citations?user=9YvhePoAAAAJ&hl=en

Selected Publications

• Asnaghi L, Lin MH, Lim KS, Lim KJ, Tripathy A, Wendeborn M, Merbs SL, Handa JT, Sodhi A, Bar EE, Eberhart CG. Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation. PLoS One. 2014;9(8):e105372

• Chu Q, Orr BA, Semenkow S, Bar EE, Eberhart CG. Prolonged Inhibition of Glioblastoma Xenograft Initiation and Clonogenic Growth following In Vivo Notch Blockade. Clin Cancer Res 2013;19(12):3224-33.

• Hanaford AR, Archer TC, Price A, Kahlert UD, Maciaczyk J, Nikkhah G, Kim JW, Ehrenberger T, Clemons PA, Dan?ík V, Seashore-Ludlow B, Viswanathan V, Stewart ML, Rees M, Shamji AF, Schreiber SL, Fraenkel E(, Pomeroy SL, Mesirov JP, Tamayo P, Eberhart CG*, Raabe EH* (*corresponding authors). DiSCoVERing innovative therapies for rare tumors: combining genetically accurate disease models with in silico analysis to identify novel therapeutic targets. Clin Cancer Res. 2016

• Pierfelice TJ, Schreck KC, Dang L, Asnaghi L, Gaiano N, Eberhart CG. Notch3 Activation Promotes Invasive Glioma Formation in a Tissue Site-Specific Manner. Cancer Res 2011; 71;1115-25.101.

• Raabe EH, Lim KS, Kim JM, Meeker A, Mao XG, Nikkhah G, Maciaczyk J, Kahlert U, Jain D, Bar E, Cohen KJ, Eberhart CG. BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model. Clin Cancer Res. 2011;17(11):3590-9

Honors

• National Merit Scholar, Phi Beta Kappa, University of Texas at Austin
• Elected to American Association of University Pathologists (Pluto Society), 1/1/15
• Elected to American Society for Clinical Investigation, 1/1/10
• Lucien J. Rubenstain Award for Best Paper in Neuro-oncology, AANP Meeting, 1/1/05
• Jean D Wilson Distinguished Alumni Lecturer, UT Southwestern MSTP, 1/1/04
• Burroughs Wellcome Fund Career Award, 1/1/01
• Howard Hughes Postdoctoral Research Fellowship for Physicians, 1/1/00
• Merck MSTP Fellow, 1/1/96
• March of Dimes Graduate Fellow, 1/1/92
• Deutches Akademisches Austauschdienst Graduate Fellow, 1/1/88

Graduate Program Affiliations

• Pathobiology

Memberships

• American Association for Cancer Research
• American Association of Neuropathology
• Association for Research in Vision and Ophthalmology
• Eastern Cooperative Oncology Group
• Society for Neuro-Oncology
• Verhoeff Zimmerman Society
• American Association of Ophthalmic Oncology and Pathology
• United States and Canadian Academy of Pathology
• International Society for Ocular Oncology
• Children‚Äôs Oncology Group,

  Member of CNS Disease Committee and Co-director of Low Grade Astrocytoma Subcommittee

Professional Activities

• Journal of Neuropathology and Experimental Neurology, Editorial board, 1/1/05
• Neuro-Oncology, Editorial board, 1/1/06
• Society for Neurooncology (SNO), Abstract Review for Scientific Program, 1/1/06
• WHO, Classification of Tumours of the Nervous System Editorial and Consensus Conference, 1/1/06