Arthur Burnett, MD

Professional Titles

• Director, Basic Science Laboratory in Neuro-Urology
• Patrick C. Walsh Professor of Urology
• Director, Sexual Medicine Fellowship Program

Primary Academic Title

Professor of Urology

Background

Centers and Institutes

• Brady Urological Institute
• Reconstructive Urology
• The Johns Hopkins Precision Medicine Center of Excellence for Prostate Cancer
• Transgender and Gender Expansive Health, Center for

Clinical Trial Keywords

Erectile Dysfunction

Clinical Trials Summary

Improving Quality of Life of Prostate Cancer Survivors with Androgen Deficiency; 2021-24; NIH-NIA; co-PI:S Bhasin (Brigham and Women’s Hospital, MA); AL Burnett

Patient – Reported Erectile Recovery and Quality of Life Outcomes with Lyopreserved Placental Tissue Applied Directly over Neurovascular Bundle during Nerve-Sparing, Radical Prostatectomy Versus Standard of Care; 2021; Johns Hopkins Univ; PI: AL Burnett

Long-Term Prospective Registry to Evaluate Treatment Decisions and Clinical Outcomes in Prostate Cancer Patients from Diverse Urology Practice Settings following Prolaris Testing; 2021; Myriad Genetics Inc; PI: AL Burnett

A Multi-Centre, Randomized, Open-Label, Home Use, Parallel Group, Clinical Investigation of Topically-Applied MED3000 Gel and Oral Tadalafil (5 mg) Tablets for the Treatment of Erectile Dysfunction (ED) over a 24-week Period; 2020-22; Futura Medical; Coordinating PI: AL Burnett 

Videos

• Meet Dr. Burnett

• Erectile Dysfunction | Evidence Based Causes and Treatments Webinar

Additional Academic Titles

Professor of Oncology

Research Interests

Cystocele, Enterocele, Erectile dysfunction, Erection physiology, Male sexual dysfunction, Pelvic floor disorders, Pelvic relaxation, Penile cancer, Penile deformities, Peyronie's disease, Prostate cancer, Rectocele, Scrotal cancer, Sexual disorders and dysfunctions, Stress incontinence, Urethral cancer

Lab Website

Neuro-Urology Laboratory - Lab Website

• The basic science laboratory in neurourology, headed by Arthur L. Burnett, M.D., is one of the independent research laboratories within the Brady Urological Institute.

  The laboratory focuses on biological mechanisms of the pelvis as these relate to erectile and voiding dysfunctions primarily. The direction of research aims to understand the neurophysiology as well as vascular physiology of the lower genitourinary tract, with an emphasis on the translational aspect of basic science discoveries relevant to the human condition. Overall, the laboratory is geared toward improving and preserving erectile and voiding dysfunctions that occur as a result of pelvic disorders and consequences from treatment of these disorders.

Research Summary

Dr. Burnett has led the basic science laboratory in neurourology for the last 30 years. Principal research studies have focused on the neurophysiology of the pelvis along with molecular mechanisms largely specific to nerve regulation of erectile and voiding functions.

Original discoveries in the laboratory include the description of nitric oxide as the principal neurotransmitter regulating penile erection. This discovery contributed to an understanding of the science of penile erection in the early 1990s from which drugs such as Viagra, Levita and Cialis were developed. The laboratory has continued major studies in the areas of nitric oxide biology in the pelvis as they relate to other erection disorders such as priapism, a condition of prolonged penile erection.

The laboratory has focused on improving outcomes with radical prostatectomy, particularly as these relate to the recovery of urinary and erectile functions. Primary efforts have gone toward the investigation and development of chemical compounds for application in men undergoing radical prostatectomy in hopes that erectile function will be better preserved. Collaboration with neuroscientists at this institution have established a role for neuroimmunophilins, special proteins localized to nerves which appear to be the receptor molecules for specialized drugs that can be taken to thereby protect the nerves from significant damage. Experimental models in rats with nerve injury leading to erectile dysfunction similar to that occurring in men after radical prostatectomy have been used demonstrating the major potential for drugs based on this pathway to be developed and used in the near future.

Ongoing projects involve the study of novel approaches, using stem cells implantable stimulators that may serve the purpose of recovering penile nerve function in men undergoing radical prostatectomy.

PubMed

http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=Burnett%20AL

Selected Publications

• .Redett, R.J. 3rd, Etra, J.W., Brandacher, G., Burnett, A.L., Tuffaha, S.H., Sacks, J.M., Shores, J.T., Bivalacqua, T.J., Bonawitz, S., Cooney, C.M., Coon, D., Pustavoitau, A., Rizkalla, N.A., Jackson, A.M., Javia, V., Fidder, S.A.J., Davis-Sproul, J., Brennan, D.C., Sander, I.B., Shoham, S., Sopko, N.A., Lee. W.P.A., Cooney, D.S.: “Total Penis, Scrotum, and Lower Abdominal Wall Transplantation.” N Engl J Med. 381(19) (2019), 1876-78.

• Burnett A.L.: “Penile Preserving and Reconstructive Surgery in the Management of Penile Cancer.”                      Nat Rev Urol. 13(5) (2016), 216-25

• Burnett, A.L., Edwards, N.C., Barrett, T.M., Nitschelm, K.D., Bhattacharyya, S.K.: “Addressing Health-Care System Inequities in the Management of Erectile Dysfunction: A Call to Action.” Am J Mens Health. 14(5) (2020), 1557988320965078

• Burnett, A.L., Nehra, A., Breau, R.H., Culkin, D.J., Faraday, M.M., Hakim, L.S., Heidelbaugh, J., Khera, M., McVary, K.T., Miner, M.M., Nelson, C.J., Sadeghi-Nejad, H., Seftel, A.D., Shindel, A.W.: “Erectile Dysfunction: AUA Guideline.” J Urol. 200(3) (2018), 633-41.

• Salonia, A., Burnett, A.L., Graefen, M., Hatzimouratidis, K., Montorsi, F., Mulhall, J.P., Stief, C.: ”Prevention and Management of Postprostatectomy Sexual Dysfunctions.  Part 1: Choosing the Right Patient at the Right Time for the Right Surgery.” Eur Urol. 62 (2012) 261-72.

Patents

• Treatments for Male Sexual Dysfunction,

  Methods and devices are taught for regulating penile erection and urethral function. Inhibitors of nitric oxide synthase and precursors of nitric oxide are applied to relax or contract the muscles of the corpus cavernosum and the urethra.

  5,439,938
• Prevention and Treatment of Erectile Dysfunction, Pending (JHU Ref. 4446)
• Method for Treating Nerve Injury Caused as a Result of Surgery,

  Methods for treating nerve injury caused as a consequence of surgery, and specifically as a consequence of prostate surgery, or for methods of neuroprotection of penile innervation, by administering a neurotrophic compound to a patient in need thereof 10/156/735

Honors

• Distinguished Mentor Award, Urology Care Foundation, American Urological Association
• Martin Luther King Jr. Award for Community Service, Johns Hopkins University
• 2021 Distinguished Scholar Alumnus Award; Urology Care Foundation
• Honorary Member, 2021; American Urological Association
• Ferdinand C. Valentine Medalist, 2020; The Section on Urology of The New York Academy of Medicine
• 2019 Honoree; Caribbean Urological Association
• Top Doctor of the Decade, 2019; International Association of Top Professionals
• Andrology Journal Award, 2018 Best Article Published in Andrology, 2019; American Society of Andrology
• Birdland Community Hero Award, 2018; Baltimore Orioles
• Distinguished Contribution Award, 2018; American Urological Association
• Top Professional of the Year Award, 2018; International Association of Top Professionals
• Diplomate, American Board of Urology
• Best Paper in Basic Science 2022; The Journal of Sexual Medicine, The Journal of Sexual Medicine, 1/1/22
• Faculty Teaching Award, Department of Urology, 1/1/10
• Edward J. Stegman CPA Memorial Award (4.0 GPA), Johns Hopkins Carey Business School, 1/1/09
• Alumni Member, Alpha Omega Alpha Honor Medical Society, 1/1/09
• Certificate of Appreciation, American Society of Andrology, 1/1/08
• First Place Award for Excellence, 27th Annual Jackson Hole Urology Conference, 1/1/07
• Zorgniotti-Newman Prize, for Best Paper on Clinical Research in Sexual Medicine, 12th World Congress of the International Society for Sexual Medicine, 1/1/06
• Jean Francois Ginesti; Prize, for Best Paper on Basic Science on Sexual Medicine (co-author), 11th World Congress of the International Society for Sexual and Impotence Research, 1/1/04
• Emil Tanagho Prize, for Best Innovative Research (co-author), 10th World Congress of the International Society for Sexual and Impotence Research, 1/1/02
• Yamanouchi Best Abstract Prize in Impotence, American Urological Association, 1/1/01
• Fellow, American College of Surgeons, 1/1/99
• Pfizer Scholar in Urology Award, Pfizer, Inc., 1/1/99
• Yamanouchi Best Abstract Prize in Impotence, American Urological Association, 1/1/98
• Merck Clinician Scientist Award, Merck & Co., 1/1/96
• First Place, Lapides Annual Essay Contest on Urodynamic and Neurourology Research, American Urological Association, 1/1/96
• Searle New Investigator Research Award, American Foundation for Urologic Disease, Inc., 1/1/94
• Male Reproduction/Urology Prize Paper, American Fertility Society, 1/1/93
• Second Place, Lapides Annual Essay Contest on Urodynamic and Neurourology Research, American Urological Association, 1/1/93
• First Place, Laboratory Research, Annual Resident Prize Essay Contest, American Urological Association, 1/1/93
• First Place, Basic Science, Resident Essay Competition, Mid-Atlantic Section of the American Urological Association, 1/1/92
• Student Merit Award, American Society of Andrology, 1/1/92
• Young Investigator Award for Post-Doctoral Investigation, Clinical Science, The Johns Hopkins University School of Medicine, 1/1/92
• Summer Research Fellowship Program, Clinical Neurogenetics Branch, National Institute of Mental Health, National Institute of Health, Warren G. Magnuson Clinical Center, 1/1/85
• Charles M. Cannon Memorial Prize, Biology Department Thesis Symposium, Princeton University, 1/1/84
• Distinguished Military Graduate, Princeton University, R.O.T.C. Unit, 1/1/84
• Order of Merit List, R.O.T.C. Advanced Camp, Fort Bragg, North Carolina, 1/1/83
• Eagle Scout, Boy Scouts of America, 1/1/76

Memberships

• American Medical Association
• American Society for Peripheral Nerve
• American Society of Andrology
• American Urogynecologic Society
• American Urological Association
• International Society for Impotence Research
• International Society for the Study of Women‚Äôs Sexual Health
• Medical and Chirurgical Faculty of the State of Maryland
• Monumental City Medical Society
• National Association for the Advancement of Colored People, Baltimore Branch
• National Medical Association
• Reserve Officers‚Äô Association of the United States
• Sexual Medicine Society of North America
• Sigma XI Scientific Research Society
• Society of Government Service Urologists
• Society of Urologic Prosthetic Surgeons
• The American College of Surgeons
• The Society of Black Academic Surgeons
• The Society of Genitourinary Reconstructive Surgeons
• The Society of University Urologists
• Urodynamics Society
• International Society for Sexual Medicine
• Society for Urodynamics and Female Urology
• The Society for Pelvic Research; 2016-Present, Member
• American Association of Genitourinary Surgeons; 2015-Present; Member
• Society of Basic Urologic Research; 2010-Present; Member; 2015-2016; Nominations Committee
• Alpha Omega Alpha Honor Medical Society; 2009-Present, Alumni Member; 2018-Present, Steering Committee, Johns Hopkins University
• The Society of University Urologists; 2006-Present; Member; 2014-2016, Board of Directors
• Society of Urologic Prosthetic Surgeons; 2006-2018; Member
• American Society for Peripheral Nerve; 2003-2004; Member
• International Society for the Study of Women‚Äôs Sexual Health; 2000-Present; Member
• American College of Surgeons; 1999-Present; Member
• The Society of Genitourinary Reconstructive Surgeons; 1998-Present; Member
• American Urogynecologic Society; 1998-2000; Member
• Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction; 1997-Present; Member
• The Society of Black Academic Surgeons; 1997-Present; Member
• International Society for Sexual and Impotence Research/Sexual Medicine; 1996-Present, Member; 2010-2013, Board of Directors; 2018-Present, Treasurer
• Monumental City Medical Society; 1994-Present; Member
• National Medical Association; 1994-Present; Member
• Sexual Medicine Society of North America; 1994-Present, Member; 2005-2007, Board of Directors; 2007-2010, Treasurer; 2011-2012, President-Elect; 2013-2014, President; 2015-2016, Past-President; 2017-2022, Chairman, Fellowship Committee
• American Society of Andrology; 1994-Present, Member; 2004-2007, Council Member; 2004-2009, Diversity Committee, Chairman; 2007, 2008, 2009, Industry Symposium Chairman; 2014-2016; 2016 ASA Program Committee, Co-Chairman
• Society of Government Service Urologists; 1991-2000; Member
• American Urological Association; 1990-Present,

  ; Member; 2008-Present, Abstract Review Committee; 2011, Abstract Review Committee Chairperson (Sexual Medicine); 2013-2021, Research Council; 2015-2021, Research Advocacy Committee Member; 2015-2020, Urology Care Foundation Public Education Council, Reproductive & Sexual Health Committee; 2018-24, Leadership Program Mentor; 2018, Public Policy and Advocacy Board Member; 2020, Urology Care Foundation Board of Directors Member; 2020, Diversity and Inclusion Task Force Member; 2020, Research Office, Diversity, Equity and Inclusion Committee Member; 2022-24, Exhibit Curator

• Mid-Atlantic Section of the American Urological Association; 1990-Present, Member; 2003, Nominations Committee; 2002, Local Arrangements Chairperson; 2004-2007, Board of Directors; 2007, Membership Committee; 2010, Program Committee Chairperson; 2014, President-Elect; 2015, President; 2016, Past-President
• American Medical Association; 1988-Present; Member
• Medical and Chirurgical Faculty of the State of Maryland; 1985-Present; Member
• National Association for the Advancement of Colored People, Baltimore Branch; 1984-Present; Member
• Reserve Officers‚Äô Association of the United States; 1984-Present; Member
• Sigma Xi Scientific Research Society; 1984-Present; Member

Professional Activities

• America (UDA) Contract Management Board; 2021-22, Member, Member
• American Board of Urology, Examination Committee, 1/1/01
• American Board of Urology Examination Committee; 2001-2005; Member, Member
• American College of Surgeons, Fellow
• American Society of Andrology, 2003 Program Committee, 1/1/01
• American Society of Andrology, Executive Council, 1/1/04
• American Society of Andrology, Postgraduate Course Chairman, 1/1/03
• American Society of Andrology 2003 Program Committee; 2001-Present; 2003 Postgraduate Course Chairman, Chairman
• American Society of Andrology Ad Hoc Industry Symposium Committee; 2006-2009, Chairman, Chairman
• American Society of Andrology Diversity Committee; 2004 - 2009, Chairman, Chairman
• American Society of Andrology Examination Committee; 2006-2008, Member, Member
• American Society of Andrology Executive Council; 2004-2007; Member, Member
• American Society of Andrology Journal Committee; 2019-Present, Member, Member
• American Urological Association, Prostate Cancer Guideline Update Panel, 1/1/06
• American Urological Association, Prostate Cancer Outcomes Working Group, 1/1/04 - 1/1/06
• American Urological Association, Male Circumcision Task Force, 1/1/08
• American Urological Association Foundation Research Scholar Reviews, Research Grant Review Committee, 2011, 2012, Grant Review Coommitte
• American Urological Association Male Circumcision Task Force; 2008- 2010, Member, Member
• American Urological Association Prostate Cancer Guideline Update Panel; 2009, Member, Member
• American Urological Association Prostate Cancer Outcomes Working Group; 2004-2006, Member, Member
• American Urological Association, Diversity and Inclusion Task Force; 2020-22, Member, Member
• AUA, Research Council Strategic Workgroup, 1/1/07
• AUA Research Council Strategic Workgroup; 2007, Member, Member
• AUA Research Council, Mid-Atlantic Section; 2013-2018, Representative, Representative
• AUA Update Series Advisory Committee; 2013-2018, Member, Member
• Board of Directors, Sexual Medicine Society of North America; 2005-2007, Member, Member
• Consortium for Diversity of Urologic Conditions (ConDUC), Executive Committee Member; 2019-Present, Member
• External Advisory Board, Howard University Hospital, Division of Urology; 2019-2020; Member, Member
• External Examiner, Jamaican Board of Urology Examination Committee (West Indies University); 2006, 2008, 2011, 2012, External Examiner
• FDA, Advisory Committee for Reproductive Health Drugs, 1/1/03
• FDA Advisory Committee for Reproductive Health Drugs; 2003-2007, Member, Member
• FDA Nonprescription Drugs Advisory Committee; 2012, Member, Member
• International Continence Society Terminology for Sexual Health in Men with Lower Urinary Tract and Pelvic Dysfunction Working Group, Member; 2018-Present, Member
• Jamaican Board of Urology Examination Committee (West Indies University), External Examiner, 1/1/06
• Johns Hopkins, Comprehensive Diabetes Center's Advisory Board, 1/1/97
• Johns Hopkins, Comprehensive Women's Health Center Oversight Committee, 1/1/97
• Johns Hopkins, Men's Health Advisory Board, 1/1/98
• Johns Hopkins Comprehensive Diabetes Center's Advisory Board; 1997-1998; Member, Member
• Johns Hopkins Comprehensive Women's Health Center Oversight Committee; 1997-1998; Member, Member
• Johns Hopkins Men's Health Advisory Board; 1998-2000; Member, Member
• Male Topic Area Work Group, National Heart, Lung, and Blood Institute/NIH and Health Resources Services Administration Hemoglobinopathies Uniform Medical Language Ontology Project; 2013-2014, Member, Member
• Mid-Atlantic Section of the American Urological Association, Board of Directors, 1/1/04 - 1/1/07
• Mid-Atlantic Section of the American Urological Association, Chairman, 1/1/01 - 1/1/02
• Mid-Atlantic Section of the American Urological Association, Membership Committee, 1/1/07
• Mid-Atlantic Section of the American Urological Association, Inc., Nominating Committee, 1/1/99 - 1/1/00
• National Kidney Foundation of Maryland, Medical Advisory Board, 1/1/97
• National Kidney Foundation of Maryland Medical Advisory Board; 1997-2000; Member, Member
• NIDDK, Workshop on Advancing Urologic Science and Career Development, 1/1/07
• NIDDK Workshop on Advancing Urologic Science and Career Development; 2007, Member, Member
• NIH Center for Scientific Review, Urology Study Section, 1/1/01 - 1/1/05
• PhD Thesis Examination Committee, Doctoral Student: Mikael Nils Sturny, Ecole Polytechnique Federale de Lausanne;2020, Member, Member
• Practice Guidelines Sexual Dysfunction Panel, American Urological Association, 2012-2018, Co-Chairperson, Co-Chairperson
• Sexual Medicine Society of North America, Board of Directors, 1/1/05
• Sickle Cell Disease Genitourinary Working Group, Consensus Measures for Phenotypes and Exposures (Phen X), The National Heart, Lung, and Blood Institute (NHLBI) Blood Epidemiology and Clinical Therapeutics Branch; 2021-22, Member, Member
• Society for the Study of Impotence, Website Committee, 1/1/00
• Society for the Study of Impotence, Website Committee; 2000-2003; Member, Member
• Urologic and Kidney Development and Genitourinary Diseases Study Section, NIH Center for Scientific Review; 2001-2002, Member; 2004-2007, Member/Chairperson, Member/Chairman
• Urology Times Editorial Council, Sexual Dysfunction Consultant; 2015- Present, Member