Anthony Ross Cammarato, PhD
Highlights
Languages
- English
Gender
MaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Anthony Ross Cammarato
Primary Academic Title
Associate Professor of Medicine
Background
Dr. Anthony Cammarato is an Associate Professor of Medicine and of Physiology. His research interests include the identification and manipulation of age- and mutation-dependent modifiers of cardiac function. His lab performs hierarchical modeling and imaging of contractile machinery and integrative analysis of striated muscle performance and myopathic processes.
Dr. Cammarato holds a bachelor’s degree in Biology from Mary Washington College and a Ph.D., in Physiology and Biophysics, from Boston University School of Medicine. He completed a postdoctoral fellowship at San Diego State University and worked as a staff scientist and later as an assistant research professor at the Sanford-Burnham Medical Research Institute before joining the Johns Hopkins faculty in 2011. He is a member of the American Physiological Society, the Biophysical Society, the American Society for Cell Biology, and the Genetics Society of America.
Centers and Institutes
Contact for Research Inquiries
720 Rutland Avenue
Division of Cardiology, Ross 1050
Baltimore, MD 21205
Phone: (410) 955-1807
Fax: (410) 502-2558
Research Interests
Hierarchical Modeling and Imaging of Contractile Machinery, Integrative Analysis of Striated Muscle Performance, Myopathic Processes
Lab Website
Cammarato Lab - Lab Website
The Cammarato Lab is located in the Division of Cardiology in the Department of Medicine at The Johns Hopkins University School of Medicine. We are interested in basic mechanisms of striated muscle biology. We employ an array of imaging techniques to study “structural physiology” of cardiac and skeletal muscle. Drosophila melanogaster, the fruit fly, expresses both forms of striated muscle and benefits greatly from powerful genetic tools. We investigate conserved myopathic (muscle disease) processes and perform hierarchical and integrative analysis of muscle function from the level of single molecules and macromolecular complexes through the level of the tissue itself.
Selected Publications
Blice-Baum AC, Zambon AC, Kaushik G, Viswanathan MC, Engler AJ, Bodmer R, Cammarato A. Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age-associated functional decline. Aging Cell. 2017 Feb;16(1):93-103. doi: 10.1111/acel.12543.PMID: 28090761
Madan A, Viswanathan MC, Woulfe KC, Schmidt W, Sidor A, Liu T, Nguyen TH, Trinh B, Wilson C, Madathil S, Vogler G, O'Rourke B, Biesiadecki BJ, Tobacman LS, Cammarato A. TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18822-18831. doi: 10.1073/pnas.2001692117. Epub 2020 Jul 20.PMID: 32690703
Schmidt W, Madan A, Foster DB, Cammarato A. Lysine acetylation of F-actin decreases tropomyosin-based inhibition of actomyosin activity. J Biol Chem. 2020 Nov 13;295(46):15527-15539. doi: 10.1074/jbc.RA120.015277. Epub 2020 Sep 1.PMID: 32873710
Viswanathan MC, Schmidt W, Franz P, Rynkiewicz MJ, Newhard CS, Madan A, Lehman W, Swank DM, Preller M, Cammarato A. A role for actin flexibility in thin filament-mediated contractile regulation and myopathy. Nat Commun. 2020 May 15;11(1):2417. doi: 10.1038/s41467-020-15922-5.PMID: 32415060
Viswanathan MC, Schmidt W, Rynkiewicz MJ, Agarwal K, Gao J, Katz J, Lehman W, Cammarato A. Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy. Cell Rep. 2017 Sep 12;20(11):2612-2625. doi: 10.1016/j.celrep.2017.08.070.PMID: 28903042
Memberships
- Biophysical Society, Member
- Genetics Society of America, Member
- The American Physiological Society, Member
- The American Society for Cell Biology, Member
Additional Training
San Diego State University, San Diego, CA, 2008, Postdoctoral Fellow, Molecular Genetics, Structural Biology, Cardiac Function