Christopher Chute, the Bloomberg Distinguished Professor of Health Informatics and chief research information officer for Johns Hopkins Medicine, has been recognized for his work on how clinical data are represented to support data inferencing and discovery science in the learning health system, focusing on ontologies, classifications and real-world data. He chaired the World Health Organization’s International Classification of Diseases’ 11th revision, which transformed the century-old system to support data science, and co-leads many large-scale national repositories of electronic health record data to advance outcomes research. His work has led to many discoveries that have changed clinical practice.

Jeffrey Rothstein is a professor of neurology and neuroscience, the founder and director of the Robert Packard Center for ALS (amyotrophic lateral sclerosis) Research, director of the Brain Science Institute, and founder and co-director of the ALS Clinic at Johns Hopkins.

His lab first discovered that excitotoxicity might be a common pathophysiological process in sporadic ALS, which led to the development of riluzole for ALS. Rothstein made discoveries on fundamental pathways that underlie familial and sporadic ALS, including excitotoxicity, astroglial and oligodendroglial dysfunction, and the role of nuclear pore complex and nucleocytoplasmic transport in familial and sporadic ALS.