Una D. McCann, MD

Professional Titles

• Associate Program Director JHBMC GCRC
• Director, Anxiety Disorders Program

Primary Academic Title

Professor of Psychiatry and Behavioral Sciences

Background

Centers and Institutes

• Anxiety Disorders Clinic at Johns Hopkins Bayview
• Behavioral Pharmacology Research Unit
• Heart and Vascular Institute
• Women's Cardiovascular Health Center

Additional Academic Titles

Professor of Neurology

Research Interests

Amphetamine-induced Monoamine Neurotoxicity, Neurobiology of Anxiety Disorders

Core Facility

Interdisciplinary Sleep, Research and Education (CISRE), Center for

Research Summary

Dr. McCann’s two active areas of research are in amphetamine-induced monoamine neurotoxicity (i.e., MDMA, methamphetamine, ephedrine or amphetamine-induced monoaminergic neurotoxicity) and the neurobiology of anxiety disorders. Methods used in both research spheres include neuropharmacology, PET, MRI, fMRI, polysomnography, pharmacological challenge and neuropsychiatric assessment. Studies of amphetamine neurotoxicity also include preclinical studies using microarrays, cell culture, rodents and primates.

Selected Publications

• Garg A, Kapoor S, Goel M, Chopra S, Chopra M, Kapoor A, McCann UD, Behera C. “Functional Magnetic Resonance Imaging in Abstinent MDMA Users: A Review.” Curr Drug Abuse Rev. 2015;8(1):15-25

• Mueller M, Maldonado-Adrian C, Yuan J, McCann UD, Ricaurte GA. “Studies of (±) 3,4-methylenedioxymethamphetamine (MDMA) metabolism and disposition in rats and mice: relationship to neuroprotection and neurotoxicity profile.” J Pharmacol Exp Ther. 2013 Feb;344(2):479-88

• Mueller M, Yuan J, McCann UD, Hatzidimitriou G, Ricaurte GA. “Single oral doses of (±) 3,4-methylenedioxymethamphetamine ('Ecstasy') produce lasting serotonergic deficits in non-human primates: relationship to plasma drug and metabolite concentrations.” Int J Neuropsychopharmacol. 2013 May;16(4):791-801

• Rao V, Mielke M, Xu X, Smith GS, McCann UD, Bergey A, Doshi V, Pham DL, Yousem D, Mori S. “Diffusion tensor imaging atlas-based analyses in major depression after mild traumatic brain injury.” J Neuropsychiatry Clin Neurosci. 2012 Summer;24(3):309-15

• Williams MS, Ziegelstein RC, McCann UD, Gould NF, Ashvetiya T, Vaidya D. “Platelet Serotonin Signaling in Patients With Cardiovascular Disease and Comorbid Depression.” Psychosom Med. 2019 May;81(4):352-362

Courses & Syllabi

• Cognitive Behavior Therapy Training, Psychiatry PGY-III, 1/1/04
• Anxiety Disorders Seminar, 1/1/04
• Psychiatry PGY-III Lecture Series, 1/1/04
• Medical Students Psychiatry Rotation, 1/1/04
• GIM Psychiatry Lecture Series, 1/1/02
• Introduction to Clinical Research Practicum, 1/1/02 - 1/1/03
• Introduction to Clinical Research Course, 1/1/01 - 1/1/03

Honors

• U.S. Army Commissioned Officers Award, 1/1/95
• Moos Fellowship for Clinical Research in Psychiatry, Stanford University, 1/1/87
• Sigma Xi Award in Psychology, 1/1/80
• Howard Hughes Foundation Student Scholar, Peter Bent Brigham Hospital, 1/1/80
• Phi Beta Kappa and Sigma Xi Societies, 1/1/80

Memberships

• Society for Neuroscience

Professional Activities

• Addiciones, Editorial board member
• Journal of Addiction, Editorial board member
• Journal of Sleep Disorders: Treatment and Care, Editorial board member
• Journal of Women's Health and Gender Based Medicine, Editorial board member
• Psychotherapy and Psychological Disorders, Editorial board member
• WebmedCentral Plus, Editorial board member
• Women in Medicine, Editorial board member