Sharon I. Turban, MD

Background

Lab Website

Sharon Turban Lab

• Research in the Sharon Turban Lab focuses on the effects of sodium and potassium on blood pressure and on kidney function. We lead the Chronic Kidney Disease-Potassium (CKD-K) clinical trial, funded by American Heart Association, which examines the benefits and safety of two levels of potassium intake in patients with kidney disease. Other research includes the Chronic Renal Insufficiency Cohort (CRIC) study, which aims to improve the understanding of chronic kidney disease and related cardiovascular illness.

Research Summary

Dr. Turban’s clinical research interests include the regulation of blood pressure and prevention of kidney disease, particularly the effects of sodium and potassium on blood pressure and on kidney function. She is the Principal Investigator of the completed American Heart Association-funded Chronic Kidney Disease-Potassium (CKD-K) clinical trial, which investigated the effects of dietary potassium in patients with kidney disease. She is also a Co-Investigator of several other research studies, including an intervention trial investigating the safety and efficacy of a vasopressin receptor antagonist in polycystic kidney disease, the NIH/NIDDK-sponsored Chronic Renal Insufficiency Cohort (CRIC) study, and an NIH-sponsored set of trials investigating the efficacy of tailored dietary advice and mineral supplements on lowering blood pressure.

Selected Publications

• Birju Patel; Sharon Turban; Cheryl Anderson; Jeanne Charleston; Edgar R Miller; Lawrence J Appel; A comparison of web sites used to manage and present home blood pressure readings. Journal of clinical hypertension (Greenwich, Conn.) 2010;12(6):389-95. 2010

• Edgar R Miller; Stephen P Juraschek; Cheryl A Anderson; Eliseo Guallar; Karen Henoch-Ryugo; Jeanne Charleston; Sharon Turban; Michael R Bennett; Lawrence J Appel; The effects of n-3 long-chain polyunsaturated fatty acid supplementation on biomarkers of kidney injury in adults with diabetes: results of the GO-FISH trial. Diabetes care 2013;36(6):1462-9. 2013 

• John Hayes; Kamyar Kalantar-Zadeh; Jun L Lu; Sharon Turban; John E Anderson; Csaba P Kovesdy; Association of hypo- and hyperkalemia with disease progression and mortality in males with chronic kidney disease: the role of race. Nephron. Clinical practice 2012;120(1):c8-16. 2012

• Kathleen T Beutler; Shyama Masilamani; Sharon Turban; Jakob Nielsen; Heddwen L Brooks; Shana Ageloff; Robert A Fenton; Randall K Packer; Mark A Knepper; Long-term regulation of ENaC expression in kidney by angiotensin II. Hypertension 2003;41(5):1143-50. 2003

• Matthew R Weir; Raymond R Townsend; Jeffrey C Fink; Valerie Teal; Stephen M Sozio; Cheryl A Anderson; Lawrence J Appel; Sharon Turban; Jing Chen; Jiang He; et al. Urinary sodium is a potent correlate of proteinuria: lessons from the chronic renal insufficiency cohort study. American journal of nephrology 2012;36(5):397-404. 2012

• Q Chen; S Turban; E R Miller; L J Appel; The effects of dietary patterns on plasma renin activity: results from the Dietary Approaches to Stop Hypertension trial. Journal of human hypertension 2012;26(11):664-9. 2012

• S Turban; F Fuentes; L Ferlic; R Brugada; A M Gotto; C M Ballantyne; A J Marian; A prospective study of paraoxonase gene Q/R192 polymorphism and severity, progression and regression of coronary atherosclerosis, plasma lipid levels, clinical events and response to fluvastatin. Atherosclerosis 2001;154(3):633-40. 2001 

• S Turban; K T Beutler; R G Morris; S Masilamani; R A Fenton; M A Knepper; R K Packer; Long-term regulation of proximal tubule acid-base transporter abundance by angiotensin II. Kidney international 2006;70(4):660-8. 2006

• Sharon Turban; Carol B Thompson; Rulan S Parekh; Lawrence J Appel; Effects of sodium intake and diet on racial differences in urinary potassium excretion: results from the Dietary Approaches to Stop Hypertension (DASH)-Sodium trial. American journal of kidney diseases : the official journal of the National Kidney Foundation 2013;61(1):88-95. 2013

• Sharon Turban; Edgar R Miller; Brett Ange; Lawrence J Appel; Racial differences in urinary potassium excretion. Journal of the American Society of Nephrology : JASN 2008;19(7):1396-402. 2008

• Sharon Turban; Paul J Thuluvath; Mohamed G Atta; Hepatorenal syndrome. World journal of gastroenterology : WJG 2007;13(30):4046-55. 2007

• Sharon Turban; Xiao-Yan Wang; Mark A Knepper; Regulation of NHE3, NKCC2, and NCC abundance in kidney during aldosterone escape phenomenon: role of NO. American journal of physiology. Renal physiology 2003;285(5):F843-51. 2003 

Honors

• Scientist Development Grant, American Heart Association
• Clinical Research Scholar, Johns Hopkins, 1/1/06