- Johns Hopkins School of Medicine Faculty
About Samuel Denmeade
Professional Titles
- Director Genitourinary Oncology Division
Primary Academic Title
Professor of Oncology
Background
Dr. Samuel Denmeade is the R. Dale Hughes Professor of Oncology and Urology at the Johns Hopkins University School of Medicine and Director of the Genitourinary Oncology Division for the Johns Hopkins Kimmel Cancer Center. He also has appointments in the Department of Pharmacology and Molecular Sciences and Department of Biomolecular Engineering. His areas of clinical expertise include bladder cancer, kidney cancer, prostate cancer and testicular cancer.
Dr. Denmeade earned his M.D. from the Columbia College of Physicians and Surgeons of Columbia University. He completed his residency at the University of Chicago. He performed a fellowship in oncology at The Johns Hopkins Hospital and a fellowship in medical oncology at the Johns Hopkins University School of Medicine.
His research interests include prostate cancer, bipolar androgen therapy, clinical trials and targeted drug development.
Dr. Denmeade has published over 200 papers in the area of prostate cancer research. He has received extensive funding from the NIH, the Department of Defense Prostate Cancer Research Fund and the Prostate Cancer Foundation. He is the Editor-in-Chief of the medical journal The Prostate.
Centers and Institutes
Clinical Trial Keywords
kidney cancer; bladder cancer; prostate cancer
Clinical Trials Summary
Learn more about clinical trials at the Johns Hopkins Kimmel Cancer Center.
Additional Academic Titles
Professor of Urology, Professor of Pharmacology and Molecular Sciences
Contact for Research Inquiries
201 N. Broadway
Baltimore, MD 21287
Phone: (410) 502-8341
Fax: (410) 367-2668
denmesa@jhmi.edu
Research Interests
Bipolar Androgen Therapy, Hormonal Resistance, Tumor Metabolism, Immunotherapy, Targeted Drug Development, Bladder Cancer, Cancer imaging, Prostate and Renal Cancer, Targeted therapies for cancer
Lab Website
Samuel R. Denmeade Laboratory - Lab Website
- The main research goals of my laboratory are: (1) to identify and study the biology of novel cancer selective targets whose enzymatic function can be exploited for therapeutic and diagnostic purposes; (2) to develop methods to target novel agents for activiation by these cancer selective targets while avoiding or minimizing systemic toxicity; (3) to develop novel agents for imaging cancer sites at earliest stages. To accomplish these objectives the lab has originally focused on the development of prodrugs or protoxins that are inactive when given systemically via the blood and only become activated by tumor or tissue specific proteases present within sites of tumor. Using this approach, we are developing therapies targeted for activation by the serine proteases prostate-specific antigen (PSA), human glandular kallikrein 2 (hK2) and fibroblast activation protein (FAP) as well as the membrane carboxypeptidase prostate-specific membrane antigen (PSMA). One such approach developed in the lab consists of a potent bacterial protoxin that we have reengineered to be selectively activated by PSA within the Prostate. This PSA-activated toxin is currently being tested clinically as treatment for men with recurrent prostate cancer following radiation therapy. In a related approach, a novel peptide-cytotoxin prodrug candidate that is activated by PSMA has been identified and is this prodrug candidate is now entering early phase clinical development. In addition, we have also identified a series of potent inhibitors of PSA that are now under study as drug targeting and imaging agents to be used in the treatment and detection of prostate cancer.
Selected Publications
Denmeade SR, Antonarakis EA, Markowski MC. Bipolar Androgen Therapy (BAT): A Patient’s Guide. Prostate, 2022 May;82(7):753-762
Denmeade SR, Sena LA, Wang H, Antonarakis ES, Markowski MC. Bipolar Androgen Therapy Followed by Androgen Receptor Inhibition as Sequential Therapy for Prostate Cancer. Oncologist. 2023 Apr 7:oyad055
Denmeade SR, Wang H, Agarwal N, Smith DC, Schweizer MT, Stein MN, Assikis V, Twardowski PW, Flaig TW, Szmulewitz RZ, Holzbeierlein JM, Hauke RJ, Sonpavde G, Garcia JA, Hussain A, Sartor O, Mao S, Cao H, Fu W, Wang T, Abdallah R, Lim SJ, Bolejack V, Paller CJ, Carducci MA, Markowski MC, Eisenberger MA, Antonarakis ES. TRANSFORMER: A Randomized Phase II Study Comparing Bipolar Androgen Therapy Versus Enzalutamide in Asymptomatic Men With Castration-Resistant Metastatic Prostate Cancer. J Clin Oncol. 2021 Feb 22:JCO2002759
Schweizer MT, Antonarakis ES, Wang H, Ajiboye AS, Spitz A, Cao H, Luo J, Haffner MC, Yegnasubramanian S, Carducci MA, Eisenberger MA, Isaacs JT, Denmeade SR. Effect of bipolar androgen therapy for asymptomatic men with castrate-resistant prostate cancer: Results from a pilot clinical study. Sci Trans Med. 2014: In Press
Sena LA, Kumar R, Sanin DE, Thompson EA, Rosen DM, Dalrymple SL, Antony L, Yang Y, Gomes-Alexandre C, Hicks JL, Jones T, Bowers KA, Eskra JN, Meyers J, Gupta A, Skaist A, Yegnasubramanian S, Luo J, Brennen WN, Kachhap SK, Antonarakis ES, De Marzo AM, Isaacs JT, Markowski MC, Denmeade SR. Prostate cancer androgen receptor activity dictates efficacy of bipolar androgen therapy through MYC. J Clin Invest. 2022 Dec 1;132(23):e162396
Honors
The Carolyn and Bill Stutt Scholar, Patrick C. Walsh Prostate Cancer Research Fund, 1/1/12
Graduate Program Affiliations
Locations
- Skip Viragh Outpatient Cancer Center
- 201 North Broadway Street, Viragh BLDG 5th FL, Baltimore, MD 21287
- phone: 410-955-8964
- fax: 410-367-2194
Expertise
Education
Johns Hopkins University School of Medicine
Fellowship, Oncology, 1997University of Chicago Medicine
Residency, Internal Medicine, 1992Columbia University College of Physicians and Surgeons
Medical Education, MD, 1989Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)
Ratings & Reviews
5 out of 5
141 ratings, 56 reviewsThe Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
- 5 out of 5 starsReviewed on 2/20/2025
Excellent
- 5 out of 5 starsReviewed on 2/20/2025
Dr Denmeade is definitely a good listener. He is always open and willing to listen to what I have to say.
- 5 out of 5 starsReviewed on 2/20/2025
Fantastic
- 5 out of 5 starsReviewed on 2/19/2025
The provider is an excellent resource for me - he's an expert in his field and uses his expertise to guide me in making good decisions about my care.
- 5 out of 5 starsReviewed on 2/11/2025
For the past year, I have been under Dr. Denmeade"s treatment and care for metastatic prostate cancer. I have been well satisfied. I drive 2 hours each way to see him. I am very fortunate to have the opportunity to be one of his patients. He is very experienced, competent, and personable.
- 5 out of 5 starsReviewed on 2/6/2025
Dr Denmeade is the BEST
- 5 out of 5 starsReviewed on 2/6/2025
I am a Kaiser patient with metastatic prostate cancer. Kaiser approved a consultation with Johns Hopkins for a second opinion. I chose Dr. Denmeade because of his impressive credentials, his excellent patient ratings and the fact that he treats only prostate cancer patients. He gave me valuable information which I believe will extend and improve the quality my life. I am very happy with the consultation,and grateful to Dr. Denmeade
- 5 out of 5 starsReviewed on 2/5/2025
Both Dr. Denmeade and nurse [staff] were incredibly helpful and competent
- 5 out of 5 starsReviewed on 1/23/2025
Truly the MVP. Recruiting and retaining someone of Dr. Denmeade's caliber speaks to the quality of Hopkins Medicine.. Kudos!
- 5 out of 5 starsReviewed on 1/23/2025
Excellent visit
- 5 out of 5 starsReviewed on 1/15/2025
Dr. Denmeade is outstanding
- 5 out of 5 starsReviewed on 1/15/2025
Dr. Denmeade is awesome, working through the complicated aspects of my current situation.
- 5 out of 5 starsReviewed on 1/2/2025
My provider really understands his patient, and continues to find ways to improve my health
- 5 out of 5 starsReviewed on 1/2/2025
Very confident that I'm in good hands
- 5 out of 5 starsReviewed on 12/18/2024
I have been battling prostate cancer for 24 years and seen many doctors in this time. Never have I met one that made me feel as comfortable and secure as Dr. Denmeade. I am so thankful that I have Dr. Denmeade on my team.
- 5 out of 5 starsReviewed on 12/12/2024
Consummate physician
- 5 out of 5 starsReviewed on 12/5/2024
Outstanding Oncologist!
- 5 out of 5 starsReviewed on 12/4/2024
Very happy to have opportunity to meet with him. I was provided information I needed and contact information for follow up. This visit has made my Christmas !
- 5 out of 5 starsReviewed on 11/14/2024
Dr Denmeade is on top of things and continues to be very thoughtful about my case.
- 5 out of 5 starsReviewed on 11/14/2024
Dr. Denmeade was very professional , knowledgeable, and caring
- 5 out of 5 starsReviewed on 10/30/2024
World class. Thoughtful, knowledgeable, understanding
- 5 out of 5 starsReviewed on 10/16/2024
Dr. Took appropriate amount of time and gave consideration to how far away I live from his office.
- 5 out of 5 starsReviewed on 10/16/2024
Video went well.
- 5 out of 5 starsReviewed on 10/16/2024
Dr. Denmeade is wonderful. He explained the results of my scan perfectly. We agreed on a future plan to monitor everything. He actually put me and my husband at ease.
- 5 out of 5 starsReviewed on 10/3/2024
Dr Denmeade is the most unique Dr. I have ever experienced. His personal qualities is distinctive and uncommon when faced this type of illness. I'm fortunate that he has supported thru this journey in my life!!
- 5 out of 5 starsReviewed on 10/3/2024
He was very patient. I was his last appointment of the day. Almost everyone else had left the building. He did not seem rushed at all. He is very personable. My wife and I enjoyed the visit.
- 5 out of 5 starsReviewed on 10/3/2024
Dr Denmeade is an excellent MD. I am very grateful he is my physician. Very happy with the JHopkins experience in general.
- 5 out of 5 starsReviewed on 10/3/2024
Knowledgeable , good listener, on the same team, willing to answer and discuss questions and choices
- 5 out of 5 starsReviewed on 10/2/2024
Dr Denmeade was fabulous! I cant imagine a better person in charge of my cancer treatment.
- 5 out of 5 starsReviewed on 9/11/2024
Dr Denmeade is very good to talk too. He listens and doesn't rush you.
- 5 out of 5 starsReviewed on 9/5/2024
Dr Denmeade is the best
- 5 out of 5 starsReviewed on 8/28/2024
Outstanding oncologist!
- 5 out of 5 starsReviewed on 8/15/2024
This was my first visit with Dr. Denmeade. I found him to be knowledgeable, thoughtful, respectful and truly interested in my condition. I would not hesitate to see him again nor to recommend him to someone else with similar health concerns.
- 5 out of 5 starsReviewed on 8/15/2024
Dr. Denmeade is the best, I couldn't be happier.
- 5 out of 5 starsReviewed on 8/8/2024
He has excellent bed side manner
- 5 out of 5 starsReviewed on 8/7/2024
Excellent
- 5 out of 5 starsReviewed on 8/7/2024
Very good meeting with Dr.Denmeade.
- 5 out of 5 starsReviewed on 8/1/2024
Wonderful doctor and human being
- 5 out of 5 starsReviewed on 7/25/2024
Dr Denmeade is a very good listener and offers very easy to understand opinions and advice
- 5 out of 5 starsReviewed on 7/18/2024
Great team
- 5 out of 5 starsReviewed on 7/18/2024
Always coordinated, efficient, frank and positive.
- 5 out of 5 starsReviewed on 7/18/2024
Dr. Denmeade was very well knowledge with my prostate cancer. Kind, polite, respectful and a very good listener. My wife and I absolutely appreciate Dr. Denmeade, what a great soul!!!
- 5 out of 5 starsReviewed on 7/17/2024
Dr. Denmeade spent all the time needed to answer all my questions and provide me with the information I needed.
- 5 out of 5 starsReviewed on 7/10/2024
Dr Denmeade answered all of my questions, answered my email right away and was professional, caring and had all the answers
- 5 out of 5 starsReviewed on 6/19/2024
Excellent
- 5 out of 5 starsReviewed on 5/16/2024
Very personable and knowledgeable.
- 5 out of 5 starsReviewed on 5/16/2024
Dr Denmeade is knowledgeable and very kind
- 5 out of 5 starsReviewed on 5/2/2024
Great bed side manner, down to earth and focused on my issues
- 5 out of 5 starsReviewed on 4/18/2024
I am very pleased with every aspect of my care at JH.
- 5 out of 5 starsReviewed on 4/18/2024
Provider is very patient oriented.
- 5 out of 5 starsReviewed on 4/18/2024
Dr Denmeade is professional, personable and explained everything to where I understood what he was telling me.
- 5 out of 5 starsReviewed on 4/4/2024
I consider it a privilege to be in Dr. Denmeade's care. I feel very confident that I will be receiving the best possible care, regardless of what happens in the future.
- 5 out of 5 starsReviewed on 4/4/2024
Very knowledgeable
- 5 out of 5 starsReviewed on 4/4/2024
Dr Denmeade was fabulous. He made me feel much more comfortable about my condition and thoroughly explained all the possible side effects of various treatments.
- 5 out of 5 starsReviewed on 4/3/2024
Dr Denmeade is the best because he is constantly looking to innovating way to heal, and he give you hope!!
- 5 out of 5 starsReviewed on 3/27/2024
Caring understanding