
Lirong Shao, MD
- Johns Hopkins School of Medicine Faculty
Languages
- English
Gender
MaleAbout Lirong Shao
Primary Academic Title
Assistant Professor of Neurology
Background
Dr. Shao received his medical and master's degrees from Soochow University Medical School (China), and postdoctoral training in neuroscience at Colorado State University and the University of Utah. Dr. Shao was a Research Assistant Professor of Pharmacology at Uniformed Services University of the Health Sciences at Bethesda, MD before he joined Johns Hopkins in 2014.
Dr. Shao pursues a research career focusing on understanding cellular mechanisms of acquired epilepsy as well as novel treatments for epilepsy. Using animal models of acquired epilepsy and electrophysiological and pharmacological techniques, he studies the roles of excitatory neuronal circuits, inhibitory synaptic transmission, as well as neuronal network in the process of epileptogenesis. He is committed to continue exploring novel mechanisms of acquired epilepsy and new approaches for epilepsy treatment and prevention.
Research Interests
Acquired epilepsy, Anti-epileptic treatment, Cerebral edema, Epilepsy prevention, GABA neurons, Hippocampus, Metabolism-neuronal excitability coupling, Neural circuit, Neuron-glial interaction, Synaptic transmission
Selected Publications
Shao L-R and Dudek FE (2004). Increased excitatory synaptic activity and local connectivity of hippocampal CA1 pyramidal cells in rats with kainate-induced epilepsy. Journal of Neurophysiology 92:1366-1373
Shao L-R and Dudek FE (2005). Changes in mIPSCs and sIPSCs after kainate treatment: evidence for loss of inhibitory input to dentate granule cells and possible compensatory responses. Journal of Neurophysiology 94:952-960
Shao L-R and Dudek FE (2005). Electrophysiological evidence using focal flash photolysis of caged glutamate that CA1 pyramidal cells receive excitatory synaptic input from the subiculum. Journal of Neurophysiology 93:3007-3011
Shao L-R and Dudek FE (2009). Both synaptic and intrinsic mechanisms underlie the different properties of population bursts in the hippocampal CA3 area of immature versus adult rats. Journal of Physiology 587:5907-5923
Shao L-R and Dudek FE (2011). Repetitive perforant-path stimulation induces epileptiform bursts in minislices of dentate gyrus from rats with kainate-induced epilepsy. Journal of Neurophysiology 105:522-527
Professional Activities
- Frontiers in Cellular Neuroscience, Ad-hoc Reviewer, 10/1/14
- Neuroscience, Ad-hoc Reviewer, 7/1/07