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Joseph L. Mankowski

Joseph L. Mankowski, DVM, PhD

Johns Hopkins Affiliations:
  • Johns Hopkins School of Medicine Faculty

Languages

  • English

Gender

Male

About Joseph L. Mankowski

Primary Academic Title

Professor of Molecular and Comparative Pathobiology

Background

Dr. Joseph L. Mankowski is a professor of molecular and comparative pathobiology, pathology and neurology at the Johns Hopkins University School of Medicine. His research focuses on the impact of HIV on the peripheral nervous system. His lab identified biomarkers that predict the onset of central nervous system disease arising from the simian immunodeficiency virus (SIV) and human immunodeficiency virus (HIV).

His team is studying the immunopathogenesis of HIV infection using the SIV/macaque model. They are using the SIV animal model to test the FDA-approved HIV drug maraviroc for its ability to reduce damage to the nerves and heart.

Dr. Mankowski received his undergraduate degree in neurobiology and behavior from Cornell University. He earned his D.V.M. from Cornell University and his Ph.D. in human genetics from the Johns Hopkins University. He completed a residency in pathology at Johns Hopkins and joined the Johns Hopkins faculty in 1996.

Dr. Mankowski provides diagnostic pathology support for the diverse animal species used in biomedical research at Johns Hopkins and is a diplomate of the American College of Veterinary Pathologists.

Additional Academic Titles

Professor of Pathology, Professor of Neurology

Contact for Research Inquiries

733 N. Broadway
MRB 827
Baltimore, MD 21205

Phone: (410) 955-9770
Fax: (410) 955-9823
jmankows@jhmi.edu

Research Interests

Neuropathology, Retrovirology

Lab Website

Joseph Mankowski Lab

  • The Joseph Mankowski Lab studies the immunopathogenesis of HIV infection using the SIV/macaque model. Our researchers use a multidisciplinary approach to dissect the mechanism underlying HIV-induced nervous system and cardiac diseases. Additionally, we study the role that host genetics play in HIV-associated cognitive disorders.

Research Summary

The Mankowski lab group studies the immunopathogenesis of HIV infection using the SIV/macaque model.

Pathogenesis of HIV-induced nervous system and cardiac disease processes
HIV is well known for its ability to induce loss of CD4+ T-cells leading to immune suppression manifest as AIDS. HIV infection also causes debilitating disease in the brain, the peripheral nervous system and in the heart secondary to infection of macrophages. Although virus-induced damage to these organs is common, the pathogenesis remains poorly defined. Using the SIV/macaque model of HIV, we use a multidisciplinary approach to dissect the mechanisms underlying these diseases, including the central role of macrophage activation.

Host genetics and lentiviral-induced CNS disease
The role that host genetics play in HIV-associated cognitive disorders is poorly understood. We have identified a novel association between expression of a MHC class I allele in pigtailed macaques and SIV-induced CNS disease that sets the stage for studies defining how MHC class I-mediated control of SIV replication in the brain influences SIV CNS disease outcomes.

Selected Publications

  • Avalos CR, Price SL, Forsyth ER, Pin JN, Shirk EN, Bullock BT, Queen SE, Li M, Gellerup D, O'Connor SL, Zink MC, Mankowski JL, Gama L, Clements JE. Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques. J Virol. 2016;90(12):5643-56. doi: 10.1128/JVI.00290-16. PubMed PMID: 27030272; PMCID: PMC4886778

  • Dorsey JL, Mangus LM, Hauer P, Ebenezer GJ, Queen SE, Laast VA, Adams RJ, Mankowski JL. Persistent Peripheral Nervous System Damage in Simian Immunodeficiency Virus-Infected Macaques Receiving Antiretroviral Therapy. J Neuropathol Exp Neurol. 2015;74(11):1053-60. doi: 10.1097/NEN.0000000000000249. PubMed PMID: 26426267; PMCID: PMC4607660

  • Gama L, Abreu CM, Shirk EN, Price SL, Li M, Laird GM, Pate KA, Wietgrefe SW, O'Connor SL, Pianowski L, Haase AT, Van Lint C, Siliciano RF, Clements JE, Group L-SS. Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques. AIDS. 2017;31(1):5-14. doi: 10.1097/QAD.0000000000001267. PubMed PMID: 27898590; PMCID: PMC5131686

  • Klein AH, Vyshnevska A, Hartke TV, De Col R, Mankowski JL, Turnquist BP, Bosmans F, Reeh PW, Schmelz M, Carr RW, Ringkamp M. Sodium channel NaV1.8 underlies TTX-resistant axonal action potential conduction in somatosensory C-fibers of distal cutaneous nerves. J Neurosci. 2017. doi: 10.1523/JNEUROSCI.3799-16.2017. PubMed PMID: 28450535.

  • Mangus LM, Dorsey JL, Weinberg RL, Ebenezer GJ, Hauer P, Laast VA, Mankowski JL. Tracking Epidermal Nerve Fiber Changes in Asian Macaques: Tools and Techniques for Quantitative Assessment. Toxicol Pathol. 2016;44(6):904-12. doi: 10.1177/0192623316650286. PubMed PMID: 27235324; PMCID: PMC4965306

Honors

Diplomate, Veterinary Anatomic Pathology, American College of Veterinary Pathologists, 1/1/98

Graduate Program Affiliations

  • Pathobiology Graduate Program

    Cellular and Molecular Medicine Graduate Program

Professional Activities

American College of Veterinary Pathologists, Diplomate

Additional Training

Johns Hopkins University, Baltimore, MD, 1996, Comparative Pathology; University of Pennsylvania, Kennett Square, PA, 1988, Large Animal Medicine and Surgery

Expertise

Education

Johns Hopkins University

Ph.D., 1998

Cornell University

D.V.M., 1987

Cornell University

B.S., 1983