Vasan Yegnasubramanian, MD, PhD

Highlights

Languages

English

Gender

Male

Johns Hopkins Affiliations:

Johns Hopkins School of Medicine Faculty

About Vasan Yegnasubramanian

Primary Academic Title

Professor of Oncology

Background

Srinivasan "Vasan" Yegnasubramanian, M.D., Ph.D., is Professor of Oncology, Pathology, and Radiation Oncology and Molecular Radiation Sciences at the Johns Hopkins University School of Medicine. He is the Director of inHealth Precision Medicine at Johns Hopkins Medicine. He also serves as co-Director of the Experimental and Computational Genomics Core and Co-Associate Director of Precision Oncology at the Sidney Kimmel Comprehensive Cancer Center.

Led by Dr. Yegnasubramanian, the inHealth Precision Medicine program is the strategic initiative at Johns Hopkins Medicine to harness the ongoing revolutions in measurement and data science to create the intelligent, innovative health system of the future.

His research laboratory is focused on the complex interplay between genetic and epigenetic alterations in driving carcinogenesis and disease progression, and on exploiting this understanding in developing novel cancer biomarkers and therapeutic strategies.

Dr. Yegnasubramanian received his Ph.D. and M.D. at the Johns Hopkins University School of Medicine and joined the faculty in 2006.

Centers and Institutes

Sidney Kimmel Comprehensive Cancer Center

Convergence Institute

Bloomberg~Kimmel Institute for Cancer Immunotherapy

https://www.linkedin.com/in/srinivasan-yegnasubramanian-92417b13/

Clinical Trials Summary

Learn more about clinical trials at the Johns Hopkins Kimmel Cancer Center.

Additional Academic Titles

Professor of Radiation Oncology and Molecular Radiation Sciences, Professor of Pathology

Contact for Research Inquiries

1550 Orleans Street
Room 145
Baltimore, MD 21231

Phone: (410) 502-3425
Fax: (410) 502-9817
syegnasu@jhmi.edu

Research Interests

cancer epigenetics, cancer genetics, cancer biomarkers, cancer epigenetic therapy, precision medicine

Lab Website

Srinivasan Yegnasubramanian Lab - Lab Website

PubMed

https://pubmed.ncbi.nlm.nih.gov/?term=Yegnasubramanian+S%5BAuthor%5D&sort=date

Selected Publications

Haffner MC, Aryee MJ, Toubaji A, Esopi DM, Albadine R, Gurel B, Isaacs WB, Bova GS, Liu W, Xu J, Meeker AK, Netto G, De Marzo AM, Nelson WG, Yegnasubramanian S. Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements. Nature genetics. 2010;42(8): 668-75. PMCID: 3157086.
Aryee MJ, Liu W, Engelmann JC, Nuhn P, Gurel M, Haffner MC, Esopi D, Irizarry RA, Getzenberg RH, Nelson WG, Luo J, Xu J, Isaacs WB, Bova GS, Yegnasubramanian S. DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases. Science translational medicine. 2013;5(169): 169ra10. PMCID: 3577373.
Haffner MC, Mosbruger T, Esopi DM, Fedor H, Heaphy CM, Walker DA, Adejola N, Gurel M, Hicks J, Meeker AK, Halushka MK, Simons JW, Isaacs WB, De Marzo AM, Nelson WG, Yegnasubramanian S. Tracking the clonal origin of lethal prostate cancer. The Journal of clinical investigation. 2013;123(11): 4918-22. PMCID: 3809798.
Graham MK, Chikarmane R, Wang R, Vaghasia A, Gupta A, Zheng Q, Wodu B, Pan X, Castagna N, Liu J, Meyers J, Skaist A, Wheelan S, Simons BW, Bieberich C, Nelson WG, DeWeese TL, De Marzo AM, Yegnasubramanian S. Single-cell atlas of epithelial and stromal cell heterogeneity by lobe and strain in the mouse prostate. Prostate. 2023 Feb;83(3):286-303. doi: 10.1002/pros.24460. Epub 2022 Nov 13. PMID: 36373171.
Caushi JX, Zhang J, Ji Z, Vaghasia A, Zhang B, Hsiue EH, Mog BJ, Hou W, Justesen S, Blosser R, Tam A, Anagnostou V, Cottrell TR, Guo H, Chan HY, Singh D, Thapa S, Dykema AG, Burman P, Choudhury B, Aparicio L, Cheung LS, Lanis M, Belcaid Z, El Asmar M, Illei PB, Wang R, Meyers J, Schuebel K, Gupta A, Skaist A, Wheelan S, Naidoo J, Marrone KA, Brock M, Ha J, Bush EL, Park BJ, Bott M, Jones DR, Reuss JE, Velculescu VE, Chaft JE, Kinzler KW, Zhou S, Vogelstein B, Taube JM, Hellmann MD, Brahmer JR, Merghoub T, Forde PM, Yegnasubramanian S, Ji H, Pardoll DM, Smith KN. Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers. Nature. 2021 Aug;596(7870):126-132. doi: 10.1038/s41586-021-03752-4. Epub 2021 Jul 21. Erratum in: Nature. 2021 Oct;598(7881):E1. doi: 10.1038/s41586-021-03893-6. PMID: 34290408; PMCID: PMC8338555.