
Arnold Bakker, PhD
- Johns Hopkins School of Medicine Faculty
Languages
- English
Gender
MaleAbout Arnold Bakker
Professional Titles
- Director, Psychiatry Neuroimaging Core
Primary Academic Title
Associate Professor of Psychiatry and Behavioral Sciences
Clinical Trial Keywords
Mild Cognitive Impairment (MCI); Functional neuroimaging; Memory impairment; Levetiracetam (Keppra)
Clinical Trials Summary
Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI)
Additional Academic Titles
Associate Professor of Neurology
Contact for Research Inquiries
Phipps Building
600 N. Wolfe Street
Baltimore, MD 21287
Phone: (410) 502-6944
Fax: (410) 614-3676
abakker@jhmi.edu
Research Interests
Cognitive neuroscience of human memory, Diffusion tensor imaging and magnetic resonance spectroscopy, Experimental behavioral assessment and advanced neuroimaging methods, Impaired memory function in aging and disease using neuropsychological assessment, Neural mechanisms of normal memory function, Structural and functional magnetic resonance imaging
Lab Website
Bakker Memory Laboratory - Lab Website
Research Summary
My research focuses on the cognitive neuroscience of human memory. I study the neural mechanisms underlying normal memory function and impaired memory function in aging and disease using neuropsychological assessment, experimental behavioral assessment and particularly advanced neuroimaging methods, including structural and functional magnetic resonance imaging, diffusion tensor imaging, and magnetic resonance spectroscopy.
Selected Publications
Bakker A, Albert MS, Krauss G, Speck CL, Gallagher M., Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance. NeuroImage. Clinical. 2015; 7:688-98. PubMed [journal]PMID: 25844322 PMCID: PMC4377841
Bakker, A., Kirwan, C.B., Miller, M., & Stark, C.E.L. (2008). Pattern separation in the human hippocampal CA3 and dentate gyrus. Science, 319, 1640-1642
Bakker, A., Krauss, G.L., Albert, M.S., Speck, C.L., Jones, L.R., Stark, C.E., Yassa, M.A., Bassett, S.S., Shelton, L., & Gallagher, M. (2012). Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron, 74, 467-474
Marchette, S., Bakker, A., & Shelton, A.L. (2011). Cognitive mappers to creatures of habit: differential engagement of place and response learning mechanisms predicts human navigational behavior. Journal of Neuroscience, 31, 15264-15268
Tran, T.T., Speck, C.L., Pisupati, A., Gallagher, M., & Bakker, A. (2016). Increased hippocampal activation in ApoE-4 carriers and non-carriers with amnestic mild cognitive impairment. NeuroImage: Clinical, 13, 237-245.
Graduate Program Affiliations
Psychological and Brain Sciences