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Arnold Bakker

Arnold Bakker, PhD

Johns Hopkins Affiliations:
  • Johns Hopkins School of Medicine Faculty

Languages

  • English

Gender

Male

About Arnold Bakker

Professional Titles

  • Director, Psychiatry Neuroimaging Core

Primary Academic Title

Associate Professor of Psychiatry and Behavioral Sciences

Clinical Trial Keywords

Mild Cognitive Impairment (MCI); Functional neuroimaging; Memory impairment; Levetiracetam (Keppra)

Additional Academic Titles

Associate Professor of Neurology

Contact for Research Inquiries

Phipps Building
600 N. Wolfe Street
Baltimore, MD 21287

Phone: (410) 502-6944
Fax: (410) 614-3676
abakker@jhmi.edu

Research Interests

Cognitive neuroscience of human memory, Diffusion tensor imaging and magnetic resonance spectroscopy, Experimental behavioral assessment and advanced neuroimaging methods, Impaired memory function in aging and disease using neuropsychological assessment, Neural mechanisms of normal memory function, Structural and functional magnetic resonance imaging

Lab Website

Bakker Memory Laboratory - Lab Website

Research Summary

My research focuses on the cognitive neuroscience of human memory. I study the neural mechanisms underlying normal memory function and impaired memory function in aging and disease using neuropsychological assessment, experimental behavioral assessment and particularly advanced neuroimaging methods, including structural and functional magnetic resonance imaging, diffusion tensor imaging, and magnetic resonance spectroscopy.

Selected Publications

  • Bakker A, Albert MS, Krauss G, Speck CL, Gallagher M., Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance. NeuroImage. Clinical. 2015; 7:688-98. PubMed [journal]PMID: 25844322 PMCID: PMC4377841

  • Bakker, A., Kirwan, C.B., Miller, M., & Stark, C.E.L. (2008).  Pattern separation in the human hippocampal CA3 and dentate gyrus. Science, 319, 1640-1642

  • Bakker, A., Krauss, G.L., Albert, M.S., Speck, C.L., Jones, L.R., Stark, C.E., Yassa, M.A., Bassett, S.S., Shelton, L., & Gallagher, M. (2012). Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron, 74, 467-474

  • Marchette, S., Bakker, A., & Shelton, A.L. (2011). Cognitive mappers to creatures of habit: differential engagement of place and response learning mechanisms predicts human navigational behavior. Journal of Neuroscience, 31, 15264-15268

  • Tran, T.T., Speck, C.L., Pisupati, A., Gallagher, M., & Bakker, A. (2016). Increased hippocampal activation in ApoE-4 carriers and non-carriers with amnestic mild cognitive impairment. NeuroImage: Clinical, 13, 237-245.    

Graduate Program Affiliations

  • Psychological and Brain Sciences

Expertise

Education

Johns Hopkins University

Ph.D., 2011

Johns Hopkins University

M.A., 2007

Tilburg University

B.A., 2002

Tilburg University

M.A., 2002