Ramana Sidhaye, MD
Pulmonology
Highlights
Johns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Ramana Sidhaye
Professional Titles
- Associate Director of the Physician-Scientist Pathway, Osler Residency Program
Primary Academic Title
Professor of Medicine
Background
Dr. Sidhaye is a Professor in Pulmonary and Critical Care Medicine with a joint appointment in Department of Environmental Health and Engineering in the School of Public Health and in Biomedical Engineering. She is an expert in the diagnosis and management of lung diseases including COPD and asthma as well as management of critical illness and ventilatory support.
Her lab is focused on studying lung epithelial responses to insults from non-infectious particles such as cigarette smoke and particulate matter as well as infectious insults such as virus and bacteria. A primary focus of the lab is in epithelial monolayer integrity and quantitative analysis of epithelial dysfunction with the goal of driving the epithelium towards health.
Dr. Sidhaye serves as the co-director of the Physician Scientist Pathway in the Osler Residency Program at Johns Hopkins.
She received her M.D. from the Feinberg School of Medicine at Northwestern University. She completed her residency at Northwestern and performed a fellowship in pulmonary and critical care medicine at Johns Hopkins.
Centers and Institutes
Additional Academic Titles
Professor of Biomedical Engineering
Contact for Research Inquiries
615 N. Wolfe St. E7622
Baltimore, MD 21205
Phone: (410) 502-9293
vsidhay1@jhmi.edu
Research Interests
Airway epithelial biology, Airway epithelial permeability, Alveolar repair mechanisms in chronic injury, Lung epithelial biology
Lab Website
The Sidhaye Lab - Lab Website
Core Facility
Microscopy/Confocal Imaging Core
Research Summary
Dr. Sidhaye’s research focuses on lung epithelial biology. As a principal investigator on several university and NIH sponsored grants, she has strong methodological training in bench and translational investigation. Using primary human differentiated lung cell culture models exposed to environmental particles involved in lung disease, including cigarette smoke, air pollution such as ambient/household air PM2.5, and aerosolized pollutants such as oils and dispersants, she has created in vitro exposure system to assess cellular and molecular dysregulation that leads to disease development. Using these systems she can expose primary human cells to a variety of aerosolized particles while live imaging of cellular function including measuring cilary beat frequency and track intracellular proteins. Her focus has been on molecular mechanisms by which critical epithelial proteins regulate cellular function, including cell-cell adhesive proteins such as E-cadherin, cytoskeletal proteins including actin-myosin and microtubules, as well as proteins involved in secretion and maintenance of airway surface liquid.
Graduate Program Affiliations
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Cell and Molecular Medicine
Environmental Health Sciences and Engineering
Biomedical Engineering
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XDBio
Locations
- The Johns Hopkins Hospital
- 1800 Orleans Street, Baltimore, MD 21287
- phone: 410-955-5000
- fax: 410-955-5001
Expertise
Education
Johns Hopkins University School of Medicine
Fellowship, Pulmonary and Critical Care Medicine, 2006Northwestern University Feinberg School of Medicine
Residency, Internal Medicine, 2002Northwestern University Feinberg School of Medicine
Medical Education, MD, 1998Board Certifications
Critical Care Medicine
American Board of Internal Medicine, 2007Pulmonary Disease
American Board of Internal Medicine, 2006Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)