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Constance L. Monitto

Constance L. Monitto, MD

Pediatric Pain Medicine

Pediatric Anesthesiology

Johns Hopkins Affiliations:
  • Johns Hopkins School of Medicine Faculty

Languages

  • English

14 Insurances Accepted

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Gender

Female

About Constance L. Monitto

Primary Academic Title

Associate Professor of Anesthesiology and Critical Care Medicine

Background

Dr. Constance L. Monitto is an assistant professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. Her clinical work focuses on intraoperative anesthetic management of pediatric patients as well as attending on the pediatric acute pain service.

She serves as associate clinical director of pediatric anesthesiology at the Johns Hopkins University School of Medicine.

Dr. Monitto received her undergraduate degree in physics from Princeton University and earned her medical degree from Harvard Medical School. She completed a residency in pediatrics at The Children’s Hospital, Boston, and a residency in anesthesia at Massachusetts General Hospital. She also completed a subspecialty residency in pediatric anesthesia at The Children’s Hospital of Philadelphia (CHOP). After remaining on staff at CHOP for two years, Dr. Monitto joined the Johns Hopkins faculty in 1994.

Dr. Monitto's clinical research interest is pediatric pain management and her basic science research involves assessing the impact of epigenetic gene regulation on the development of resistance to chemotherapeutic agents in cancer.

She is a member of the American Academy of Pediatrics, the American Society of Anesthesiologists, the Society for Pediatric Anesthesia and the International Anesthesia Research Society.

Centers and Institutes

Johns Hopkins Children's Center

Research Interests

Assessing the impact of epigenetic gene regulation on the development of resistance to chemotherapeutic agents in cancer, Pediatric pain management

Lab Website

Constance Monitto Lab - Lab Website

Research Summary

Dr. Constance L. Monitto is involved in both clinical and basic science research. Her clinical research is focused on pediatric pain management. She and her coworkers are assessing the impact of low-dose opioid antagonism on opioid-related side effects, such as nausea, vomiting, and pruritis. They also are completing analysis of data regarding current methods of pediatric pain management across the country.

In her basic science studies, Dr. Monitto is assessing the impact of epigenetic gene regulation on the development of resistance to chemotherapeutic agents in cancer. She is identifying genes that are silenced or downregulated in drug-resistant cell lines and comparing those to their drug-sensitive, isogeneic counterparts by microarray assessment of gene expression followed by pharmacologic unmasking of methylated genes using the compound 5-deoxyazacytidine. Candidate genes are further assessed by siRNA gene silencing. Her clinical research involves pediatric pain management.

Selected Publications

    1. Singh D, Gross RM, Monitto C, Heitmiller E, Njoku D. “In-depth analysis of a subset of POCA registrants: impact on strategies for successful resuscitation.” Anesthesiology. 2007; 107:A1934.
    2. Nelson KL, Yaster M, Kost-Byerly S, Monitto C. “Patient controlled analgesia by proxy: results from a national survey.” Anesthesiology. 2007;107:A685.
    3. Nelson KL, Yaster M, Kost-Byerly S, Monitto C. “Pediatric pain management – results of a national survey of pediatric anesthesiologists.” Anesthesiology. 2007;107:A688.
    4. Hoque MO, Soria JC, Woo J, Lee T, Lee J, Jang SJ, Udaphyay S, Trink B, Monitto C, Desmaze C, Mao L. Sidransky D, Moon C. “Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth.” Am J Pathol. 2006;168(4):1345-1353. doi: 10.2353/ajpath.2006.050596.
    5. Xiao Y, Monitto CL, Minhas KM, Sidransky D. “Lactoferrin down-regulates G1 cyclin-dependent kinases during growth arrest of head and neck cancer cells.” Clin Canc Res. 2004;10(24):8683-8686. doi: 10.1158/1078-0432.CCR-04-098.

Honors

Research Day Award, Department of Anesthesiology and Critical Care Medicine, 1/1/09

Memberships

  • American Academy of Pediatrics
  • American Society of Anesthesiologists
  • International Anesthesia Research Society
  • Society for Pediatric Anesthesia

Professional Activities

  • Anesthesia and Analgesia, Guest Reviewer
  • British Journal of Cancer, Guest Reviewer
  • Clinical Cancer Research, Guest Reviewer

Locations

  1. The Johns Hopkins Hospital
    • 1800 Orleans Street, Baltimore, MD 21287

    Expertise

    Education

    Children's Hospital of Philadelphia

    Fellowship, Anesthesiology and Critical Care Medicine, 1991

    Massachusetts General Hospital

    Residency, Anesthesiology, 1990

    Boston Children's Hospital

    Residency, Pediatrics, 1988

    Harvard Medical School

    Medical Education, Medicine, MD, 1985

    Board Certifications

    Pediatric Anesthesiology

    American Board of Anesthesiology, 2014

    Anesthesiology

    American Board of Anesthesiology, 1992

    Insurance

    Johns Hopkins providers accept various commercial health insurance plans. However, they may not be included in all of an insurance company's plans or offerings. This may include Exchange, Medicaid, Medicare, and specific limited benefit plans. Exceptions to participation also exist based on your employer’s benefits package and the provider's location or specialty. Please contact your insurer directly to make sure your doctor is covered by your plan. For more details, please review our Insurance Information.
    Search plans
    • Aetna
    • CareFirst
    • Cigna
    • First Health
    • Geisinger Health Plan
    • HealthSmart/Accel
    • Humana
    • Johns Hopkins Health Plans
    • MultiPlan
    • Pennsylvania's Preferred Health Networks (PPHN)
    • Point Comfort Underwriters
    • Private Healthcare Systems (PHCS)
    • UnitedHealthcare
    • Veteran Affairs Community Care Network (Optum-VACCN)