Gabriel Ghiaur, MD, PhD

Primary Academic Title

Associate Professor of Oncology

Background

Centers and Institutes

Sidney Kimmel Comprehensive Cancer Center

Clinical Trial Keywords

Leukemia, Bone Marrow Transplant, Hematologic Malignancies, Natural Killer Cells

Research Interests

Bone Marrow Microenvironment, Bone Marrow Transplant, Hematopoietic Stem Cell Biology and Leukemia Stem Cells, Leukemia, Natural Killer Cells

PubMed

https://www.ncbi.nlm.nih.gov/myncbi/gabriel.ghiaur.1/bibliography/public/

Selected Publications

• Ghiaur G, Levis M. Mechanisms of Resistance to FLT3 Inhibitors and the Role of the Bone Marrow Microenvironment. Hematol Oncol Clin North Am. 2017 Aug;31(4):681-692. doi: 10.1016/j.hoc.2017.04.005. Epub 2017 May 18. Review. PubMed PMID: 28673395; PubMed Central PMCID: PMC5512588.

• Ghiaur G, Yegnasubramanian S, Perkins B, Gucwa J, Gerber J, and Jones RJ. Regulation of Hematopoietic Stem Cell Self-Renewal by the Microenvironment’s Control of Retinoic Acid Signaling. PNAS, 2013, Oct1; 110(40):16121-6. Epub 2013 Sep 16.  PMID: 24043786. PMCID: PMC3791732

• Alonso S, Hernandez D, Chang YT, Gocke CD, McCray M, Varadhan R, Matsui WH, Jones RJ, Ghiaur G. Hedgehog and retinoid signaling alters multiple myeloma microenvironment and generates bortezomib resistance. J Clin Invest. 2016 Dec 1;126(12):4460-4468. doi: 10.1172/JCI88152 PMID: 27775549

• Hernandez D, Palau L, Norsworthy K, Anders NM, Alonso S, Su M, Petkovich M, Chandraratna R, Rudek MA, Smith BD, Jones RJ, Ghiaur G. Overcoming microenvironment-mediated protection from ATRA using CYP26-resistant retinoids. Leukemia. 2020 Mar 9;. doi: 10.1038/s41375-020-0790-4. [Epub ahead of print] PubMed PMID: 32152463.

• Su M, Chang YT, Hernandez D, Jones RJ, Ghiaur G. Regulation of drug metabolizing enzymes in the leukaemic bone marrow microenvironment. J Cell Mol Med. 2019 Jun;23(6):4111-4117. doi: 10.1111/jcmm.14298. Epub 2019 Mar 28. PubMed PMID: 30920135; PubMed Central PMCID: PMC6533513

Honors

• Blood Mentor, ASH-a-Palooza, American Society of Hematology Annual Meeting, 1/1/19
• Visiting Professor in Hematopoiesis, Cluj School of Medicine, 1/1/18
• American Society of Clinical Investigator (ASCI) Young Physician-Scientist Award, 1/1/17
• Passano Physician Scientist Award, 1/1/14
• Fellow, American Society of Hematology, 1/1/12
• Fellow, Maryland Stem Cell Research, 1/1/12

Memberships

• American Association of Cancer Research
• American Society of Hematology
• Romanian Society of Hematology
• Romanian Society of Bone Marrow Transplantation, Honorary Member

Professional Activities

• Education Committee, Sidney Kimmel Comprehensive Cancer Center, Associate Chair
• Normal and Oncologic Tissue Collection Hub (NOTCH) biorepository, Director
• Visiting Professor Series and Translational Research Conference, Director