Peter Abadir, MD

Professional Titles

• Director, Molecular Measurement Core, Johns Hopkins Older Americans Independence Center (2017–Present)
• Director, Johns Hopkins GeroTech Incubators Program (2021–Present)
• Co-Principal Investigator and Co-Director, Clinical Translation and Validation Core, Johns Hopkins Artificial Intelligence and Technology Collaboratory for Aging Research (2021–Present)
• Co-Principal Investigator and Director, Johns Hopkins Post-Doctoral Translational Aging Research Training Program (2024–Present; previously Associate Director 2018–2023)
• Deputy Chief Editor, Journal of American Geriatrics Society (2024–Present)
• Chair, Johns Hopkins Medical School MD Admission Committee (2024–Present)

Primary Academic Title

Associate Professor of Medicine

Background

LinkedIn

https://www.linkedin.com/in/peter-abadir-87401715/

Clinical Trial Keywords

Aging, Frailty, Prefrail older adults, Physical function, Losartan, Antihypertensive therapy, Muscle strength, Mitochondrial health, Biomarkers, Chronic inflammation, Randomized controlled trial, Geriatrics, Clinical intervention, Aging biomarkers, Pharmacokinetics

Clinical Trials Summary

• Title: Serum Concentrations of Losartan Metabolites Correlate with Improved Physical Function in a Pilot Study of Prefrail Older Adults

  Overview:
  This pilot study explored the potential benefits of losartan in improving physical function and reducing frailty in older adults aged 70-90 years. Over six months, participants received either losartan or a placebo. Results showed a significant improvement in frailty scores and muscle strength among losartan recipients, linked to key metabolite levels. This research highlights the potential of repurposing common antihypertensive medications to address age-related frailty and improve quality of life for older adults.

  Key Findings:

• Reduced Frailty: Losartan was associated with an 89% lower likelihood of frailty compared to placebo.
• Increased Strength: Higher serum concentrations of losartan metabolites correlated with improved knee strength.
• Improved Biomarkers: Losartan treatment enhanced mitochondrial health indicators and reduced inflammation markers.

• For further information or potential participation in future studies, please visit the Human Aging Project website.

Videos

• 50 years of Geriatric Medicine at Johns Hopkins Medicine

• Artificial Intelligence & Technology Collaboratory (AITC) | Johns Hopkins Medicine

• Gerotech Program | Human Aging Project

Recent News Articles and Media Coverage

• Inflammatory Biomarker Associated with Mitochondrial Decline Further Linked to Frailty,  Johns Hopkins Medicine
• New Findings Show Mitochondrial DNA Fragments in Blood as Important Biomarkers for Aging and Inflammation, Johns Hopkins Medicine
• Blood Levels of ‘Free Range’ DNA May Signal Early Detection of Dementia and Frailty, Johns Hopkins Medicine
• A Novel Way to Heal Diabetic Wounds in Older Adults, Johns Hopkins Medicine
• New link discovered between class of rogue autoantibodies and poor health outcomes, eurekalert
• Researchers Advance Efforts to Tailor Drug Delivery to Cells’ ‘Power Plants’, Johns Hopkins Medicine
• Gerotech: technology in aging interview with Dr. Peter Abadir, Ask Dr. Mia(Jan. 31, 2023)
• Navigating and Diagnosing Cognitive Frailty in Research and Clinical Domains, Johns Hopkins Medicine

Research Interests

Improving health and resilience in aging, Developing innovative technologies and therapies, Discovery of the mitochondrial angiotensin system, Integrating artificial intelligence and bioengineering, Enhancing health and independence for older adults, Advancement of biomarkers for frailty and cognitive decline

Lab Website

Peter Abadir Lab

• Dr. Abadir's research interests include changes in the renin angiotensin aldosterone system with aging, signal transduction and the role of the cross talk between angiotensin II receptor in aging; and understanding the role of angiotensin II in the development of vascular aging.

Research Summary

Dr. Peter M. Abadir leads cutting-edge research at the intersection of aging science and technology, focusing on improving health and resilience in aging. His work has contributed to the discovery of the mitochondrial angiotensin system, the advancement of biomarkers for frailty and cognitive decline, and the development of novel therapeutic approaches such as nanogels for wound healing. Dr. Abadir is particularly interested in creating innovative technologies and therapies to address frailty, cognitive decline, and age-related conditions, integrating molecular biology, bioengineering, and artificial intelligence to design personalized interventions. Through his leadership, he combines these fields to enhance health and independence for older adults.

Google Scholar

https://scholar.google.com/scholar?q=Peter+Abadir&btnG=&hl=en&as_sdt=0%2C21

PubMed

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/44186696/?sort=date&direction=ascending

Selected Publications

• Abadir PM, Foster DB, Crow M, et al. Identification and characterization of a functional mitochondrial angiotensin system. Proceedings of the National Academy of Sciences USA (PNAS). 2011 Sep 6;108(36):14849-54. DOI: 10.1073/pnas.1101507108

• Abadir PM, Hosseini S, Faghih M, et al. Topical reformulation of valsartan for treatment of chronic diabetic wounds. Journal of Investigative Dermatology. 2017;137(11):2345-2354. DOI: 10.1016/j.jid.2017.09.030

• Abadir PM, Jain A, Powell LJ, et al. Discovery and validation of agonistic angiotensin receptor autoantibodies as biomarkers of adverse outcomes. Circulation. 2017;135:449-459. DOI: 10.1161/CIRCULATIONAHA.116.022385

• Phillip J, Lin R, Cheetham A, et al. Nature-inspired delivery of mitochondria-targeted angiotensin receptor blocker. PNAS Nexus. 2023. DOI: 10.1093/pnasnexus/pgac147

• Nader MM, Cosarderelioglu C, and Abadir PM. Navigating and diagnosing cognitive frailty in research and clinical domains. Nature Aging. 2023. DOI: 10.1038/s43587-023-00504-z

Patents

1. Presence of a Novel Protective Anti-inflammatory Receptor in Human Mitochondria and Its Role in Preserving Mitochondrial Functions

   • Co-Inventors: Abadir P, Walston J
   • Granted US Patent: 10,835,516
   • Date: May 26, 2011

2. Selective Targeting of a Novel Protective Anti-inflammatory Receptor in Human Mitochondria and Its Role in Preserving Mitochondrial Functions

   • Co-Inventors: Abadir P, Walston J
   • Granted US Patent: 10,525,144
   • Date: November 10, 2014

3. Selective Targeting of a Novel Protective Anti-inflammatory Receptor for the Healing of the Soft Tissue Wounds, Injuries, and Inflammatory Skin Conditions

   • Co-Inventors: Abadir P, Walston J
   • Granted US Patent: 10,648,977 & Pending US Application: US2021/0389319
   • Date: February 13, 2015

4. Supramolecular Hydrogels Containing Angiotensin Receptor Blockers for Targeted Treatment of Diabetic Wounds

   • Co-Inventors: Abadir P, Walston J, Honggang, Cui H, Lin X
   • Granted US Patent: 10,835,615
   • Date: October 2, 2015

5. The Design and Validation of Novel Angiotensin Type I Receptor Autoantibody Aptamers

   • Co-Inventors: Abadir P, Walston J, Fedarko N
   • Pending US Provisional Application: 63/272,335
   • Date: November 1, 2018

6. Thermosensitive Hydrogel-Nanoparticle System to Reverse Cellular Senescence and Enhance Collagen Production

   • Co-Inventors: Kokkoli E, Abadir P, Walston J, Kuhn P
   • U.S. Provisional Patent Application Filed: JHU Ref #: C16199
   • Date: September 6, 2024

Honors

•  The American Heart Association-Pharmacia New Investigator Award, 2002
• The American Heart Association-Aventis New Investigator Award, 2003
•  The Endocrine Society Hot Topics in Endocrinology Award, 2003
• The American Heart Association-Merck New Investigator Award, 2004
• University of Kentucky College of Medicine-East Kentucky Family Medicine Residency Intern of the Year Award, 2005
•  The American Academy of Family Physicians Community Outreach Award, 2006
•  The American Academy of Family Physicians Award for Excellence in Graduate Medical Education, 2006
•  The Honorable Order of Kentucky Colonels, Commonwealth of Kentucky, 2007
•  The American Academy of Family Physicians Scholarship Award for Residents, 2007
•  University of Kentucky College of Medicine-East Kentucky Family Medicine Residency Chief Resident of the Year Award, 2007
•  University of Kentucky College of Medicine-East Kentucky Family Medicine Residency Resident Merit Award, 2007
•  The North American Primary Care Research Group Recognition Award, 2007
•  The American Geriatrics Society T. Franklin Williams Research Scholars Award, 2009
•  The Johns Hopkins Clinician Scientist Award, 2009
•  The American Geriatrics Society Presidential Poster Award (Basic Science Category), 2011
•  The American Heart Association-Kidney Council New Investigator Award, 2012
•  The American Geriatrics Society Merck New Investigator Award, 2013
•  The American Geriatrics Society Geriatric Bioscience Best Paper Award, 2013
•  Nathan W. and Margaret T. Shock Aging Research Foundation – Nathan Shock Scholar in Aging, 2013
•  Wound Healing Society 3M Fellow Scholarship Award, 2014
•  The Johns Hopkins University W. Leigh Thompson Excellence in Research Award, 2015
•  Inducted into the Johns Hopkins School of Medicine Distinguished Teaching Honor Society, 2016
•  The Johns Hopkins Frederick L. Brancati Excellence in Mentoring Award, 2017
•  The American Geriatrics Society Geriatric Bioscience Best Paper Award (Senior Author), 2017
•  The American Geriatrics Society Geriatric Lightning Science Best Abstract Award (Senior Author), 2017
•  The American Geriatrics Society’s Research Committee Outstanding Committee Service Award, 2021
•  The Johns Hopkins Human Aging Project – Salisbury Family Scholar, 2021
• The Johns Hopkins Institute for Excellence in Education Award in Leadership and Mentorship, 2024

Memberships

• The American Geriatrics Society (AGS), Member
• The Gerontological Society of America (GSA), Member
• Principal Investigator and Co-Director of the Clinical Translation and Validation Core Johns Hopkins Artificial Intelligence and Technology Collaboratory for Aging Research (AITC)
• Director The Human Aging Project
• Director of the Molecular Measurement Core.Johns Hopkins Older Americans Independence Center (OAIC - Claude D. Pepper Center)
• Co-Founder and Director Johns Hopkins Gerotech Incubator Program
• Core Faculty Member Biology of Healthy Aging Research Group
• Co-Principal Investigator and Program Director Johns Hopkins Clinical Translational Aging Research Training Program (T32 Program)