
Michael G. Goggins, MD
Gastroenterology
- Johns Hopkins School of Medicine Faculty
About Michael G. Goggins
Primary Academic Title
Professor of Pathology
Background
Dr. Michael G. Goggins is a professor of pathology, medicine and oncology at the Johns Hopkins University School of Medicine. He serves as director of the Pancreatic Cancer Early Detection Laboratory and is an attending physician in medicine in the Division of Gastroenterology and Hepatology at The Johns Hopkins Hospital. He is the Sol Goldman Professor of Pancreatic Cancer Research.
Dr. Goggins’ research interests include developing tests to improve the early detection in pancreas cancer, evaluating outcomes of pancreatic surveillance and identifying gene variants responsible for inherited susceptibility to pancreatic cancer.
He obtained his medical degree in 1988 from Trinity College of the University of Dublin, Ireland. He completed a residency in internal medicine and a fellowship in Gastroenterology at St. James' Hospital in Dublin. He obtained his Membership of the Royal College of Physicians of Ireland in 1991 and his European Diploma in Gastroenterology in 1995. He joined the Johns Hopkins faculty in 1999.
Dr. Goggins is a member of the Royal College of Physicians of Ireland. He sits on the editorial boards of Gut.
Centers and Institutes
Clinical Trials Summary
The Cancer of the Pancreas Screening-5 CAPS5)Study
Recent News Articles and Media Coverage
Genetic Testing May Hold Promise in Predicting Pancreatic Cancer, Inside Tract (Fall, 2019)
New Genetic Clues to Pancreatic Cancer, Clinical Connection (Fall, 2017)
Additional Academic Titles
Professor of Medicine, Professor of Oncology
Research Interests
Early detection of pancreatic cancer, familial pancreatic cancer, markers of pancreatic cancer, pancreatic cancer epigenetics, pancreatic cancer genetics, pancreatic cancer screening
Lab Website
Early Detection of Pancreatic Cancer Laboratory - Lab Website
In the Pancreatic Cancer Early Detection Laboratory, Dr. Goggins oversees research that focuses on gene expression patterns of pancreatic cancers using microarray technology. The lab is also studying DNA methylation patterns looking for genes that are methylated in pancreatic cancer but not in normal cells.
The lab has put together a profile of genes that are methylated in pancreatic cancer. Some pancreatic cancers methylate a lot of genes; most appear to methylate only a few genes. The lab is currently directing efforts to identify additional genes methylated in pancreatic cancer using novel techniques, and is studying the role of telomerase in pancreatic cancer and its potential as a marker for early detection.
Research Summary
Dr. Goggins’ current research is focused on discovering new markers of pancreatic adenocarcinoma using genetic, epigenetic and proteomic strategies, characterizing the epigenetic alterations in pancreatic cancers and normal tissues and identifying familial pancreatic cancer susceptibility genes through linkage, genome wide association and candidate gene approaches. Additional epigenetic studies are aimed at determining the functional and clinical significance of aberrant DNA methylation changes in pancreatic cancers.
Selected Publications
Goggins M, Overbeek KA, Brand R, Syngal S, Del Chiaro M, Bartsch DK, Bassi C, Carrato A, Farrell J, Fishman EK, Fockens P, Gress TM, van Hooft JE, Hruban RH, Kastrinos F, Klein A, Lennon AM, Lucas A, Park W, Rustgi A, Simeone D, Stoffel E, Vasen HFA, Cahen DL, Canto MI, Bruno M: Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium. Gut 2020, 69:7-17. doi: 0.1136/gutjnl-2019-319352. Epub 2019 Oct 31
Abe T, Blackford AL, Tamura K, Ford M, McCormick P, Chuidian M, Almario JA, Borges M, Lennon AM, Shin EJ, Klein AP, Hruban RH, Canto MI, Goggins M: Deleterious Germline Mutations Are a Risk Factor for Neoplastic Progression Among High-Risk Individuals Undergoing Pancreatic Surveillance. J Clin Oncol 2019, 37:1070-80
Abe T, Koi C, Kohi S, Song KB, Tamura K, Macgregor-Das A, Kitaoka N, Chuidian M, Ford M, Dbouk M, Borges M, He J, Burkhart R, Wolfgang CL, Klein AP, Eshleman JR, Hruban RH, Canto MI, Goggins M: Gene Variants That Affect Levels of Circulating Tumor Markers Increase Identification of Patients With Pancreatic Cancer. Clin Gastroenterol Hepatol 2020, 18:1161-9.e5. doi: 10.016/j.cgh.2019.10.036. Epub Oct 30
Blackford AL, Canto MI, Klein AP, Hruban RH, Goggins M: Recent trends in the incidence and survival of Stage 1A Pancreatic Cancer: A Surveillance, Epidemiology, and End Results analysis. J Natl Cancer Inst 2020, 112:1162-9
Tamura K, Yu J, Hata T, Suenaga M, Shindo K, Abe T, MacGregor-Das A, Borges M, Wolfgang CL, Weiss MJ, He J, Canto MI, Petersen GM, Gallinger S, Syngal S, Brand RE, Rustgi A, Olson SH, Stoffel E, Cote ML, Zogopoulos G, Potash JB, Goes FS, McCombie RW, Zandi PP, Pirooznia M, Kramer M, Parla J, Eshleman JR, Roberts NJ, Hruban RH, Klein AP, Goggins M: Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer. Proc Natl Acad Sci U S A 2018, 115:4767-72
Graduate Program Affiliations
Pathology
Pathobiology
Memberships
- European Board of Gastroenterology
- Royal College of Physicians of Ireland
Locations
- Johns Hopkins Health Care & Surgery Center - Green Spring Station, Lutherville
- 2360 West Joppa Road, Joppa Concourse STE 205, Lutherville, MD 21093
- phone: 410-933-7495
- fax: 410-616-7351
Expertise
Education
Johns Hopkins University School of Medicine
Fellowship, 1998St James's Hospital
Fellowship, Internal Medicine, 1995St James's Hospital
Residency, Medicine, 1991St James's Hospital
Residency, 1989University of Dublin Trinity College
Medical Education, MD, 1988Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)
Ratings & Reviews
4.9 out of 5
41 ratings, 13 reviewsThe Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
- 5 out of 5 starsReviewed on 12/10/2024
Excellent in every way! Brilliant, thorough and informative.
- 5 out of 5 starsReviewed on 10/22/2024
Pleasant, clear, will informed about my situation, gave alternatives as well as providing clear guidance to best decision
- 5 out of 5 starsReviewed on 10/8/2024
Knowledgeable, good listener and communicator
- 4 out of 5 starsReviewed on 10/8/2024
Very knowledgeable
- 5 out of 5 starsReviewed on 10/8/2024
Dr. Goggins and I had a good initial meeting as I joined his Pancreatic Cancer for Braca 1 Positive individuals. He was very considerate when he found out I needed to postpone my endoscopy due to a Cervical Fusion I was having and had to postpone the endoscopy for 3 months. It made me feel like I was valued for his study.
- 5 out of 5 starsReviewed on 9/24/2024
Excellent
- 5 out of 5 starsReviewed on 9/24/2024
For being the first provider and I have never met him I really like him. He really listens to what you have to say.
- 5 out of 5 starsReviewed on 8/13/2024
Dr. Goggins is an extremely patient doctor. I am an anxious person and probably repeated myself with questions several times and he was very patient and assuring.
- 5 out of 5 starsReviewed on 5/28/2024
This was my first video call with Dr. Goggins. He was very respectful and thorough, and transparent during our conversation.
- 5 out of 5 starsReviewed on 5/14/2024
Happy with provider per se, BUT making aptm & accessing location VERY DIFFICULT!
- 5 out of 5 starsReviewed on 4/23/2024
I feel lucky to be able to get care from a doctor of this caliber without being rich or famous.
- 5 out of 5 starsReviewed on 4/23/2024
Dr. Goggins has excellent patient and understanding expertise; is a knowledgeable and thorough physician.
- 5 out of 5 starsReviewed on 4/9/2024
This was my first meeting with Dr. Goggins and he is terrific ... Knowledgable, thorough, compassionate.