Mark A. Mirski, MD, PhD

Professional Titles

• Vice-Chair, Department of Anesthesiology and Critical Care Medicine
• Director, Johns Hopkins Neuroscience Critical Care Units
• Chief, Division of Neuroanesthesiology
• Co-Director, Johns Hopkins Comprehensive Stroke Center
• Director of Neuroanesthesia and Critical Care Medicine Division

Primary Academic Title

Professor of Anesthesiology and Critical Care Medicine

Background

Centers and Institutes

Stroke Center at The Johns Hopkins Hospital

CV

http://www.hopkinsmedicine.org/anesthesiology_critical_care_medicine/research/experts/research_faculty/bios/cvs/mirski.pdf

Additional Academic Titles

Professor of Neurological Surgery, Professor of Neurology

Research Interests

Investigation of the subcortical mechanisms of seizure propagation and cortical synchrony

Lab Website

Marek Mirski Lab - Lab Website

Research Summary

Dr. Mirski’s laboratory research involves the investigation of the subcortical mechanisms of seizure propagation and cortical synchrony. The lab directs major effort toward the development of methodologies for seizure inhibition via site-specific subcortical electrical stimulation. The principal finding of his research—identification of synaptically linked subcortical elements important in seizure propagation—has led to FDA-sanctioned Phase III clinical trials of targeted thalamic stimulation in patients with intractable seizures. Dr. Mirski also conducts primary research in the treatment of brain edema, ICU sedation and acute stroke.

Additional research activities include investigation of the proconvulsant action of novel alpha2-receptor agonists and pharmacologic osmolar control of elevated intracranial pressure following acute head injury. Major clinical investigations are focused on the treatment of elevated intracranial pressure, cerebral edema, ICU sedation, and clinical trials for ischemic stroke and head injury.

Selected Publications

• 1. Koenig MA, Bryan M, Lewin JJ, Mirski MA, Geocadin RG, Stevens RD. “Reversal of transtentorial herniation with hypertonic saline.” Neurology 70(13):1023–9, 2008.
  2. Hamani C, Hodaie M, Chiang J, del Campo M, Andrade DM, Sherman DL, Mirski MA, Mello LE, Lozano AM. “Deep brain stimulation in the anterior thalamus: Effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus.” Epilepsy Res 78(2–3):117–23, 2008.
  3. Mirski MA, Nyquist P, Toung TJ. “Effect of hypertonic saline concentration on cerebral and visceral organ water in an uninjured rodent model.” Crit Care Med 36(1):256–61, 2008.
  4. Bhatti N, Mirski MA, Tatlipinar A, Koch WM, Goldenberg D. “Reduction of complication rate in percutaneous dilation tracheotomy.” Study of 318 consecutive patients. Otolaryngology 117:172–5, 2007.
  5. Ziai WC, Sherman DL, Zhang N, Bhardwaj A, Mirski MA.” Target-specific catecholamine elevation induced by anticonvulsant thalamic deep brain stimulation.” Epilepsia 46:878–88, 2005.

Honors

• First Johns Hopkins Medicine Joint Director
• Most Influential Physician, Queen's Medical Center, 1/1/98
• Founding Director, Queen's Neuroscience Institute, 1/1/96
• Co-Winner, Neuroscience Research Prize, Washington University/St. Louis Medical Center, 1/1/86

Memberships

• American Academy of Neurology
• American Epilepsy Society
• American Neurological Association
• American Society of Anesthesiology
• Society of Critical Care Medicine
• Society of Neurosurgical Anesthesia and Critical Care

Professional Activities

• American Academy of Neurology, Scientific Co-Chair, 1/1/03
• American Journal of Neuroradiology, Ad-hoc reviewer
• American Society of Anesthesiology, FAER Awards Committee, 1/1/03 - 1/1/05
• American Society of Anesthesiology, Scientific Co-Chair, 1/1/02
• Anesthesia & Analgesia, Ad-hoc reviewer
• Anesthesiology, Ad-hoc reviewer
• Annals of Neurology, Ad-hoc reviewer
• Contemporary Critical Care, Ad-hoc reviewer
• Contemporary Critical Care, Editorial board
• Critical Care Medicine, Ad-hoc reviewer
• Epilepsia, Ad-hoc reviewer
• Epilepsy Research, Ad-hoc reviewer
• Journal Neurocritical Care, Editorial board
• Journal of Experimental Neurology, Ad-hoc reviewer
• Journal of Neurocritical Care, Ad-hoc reviewer
• Journal of Neurosurgical Anesthesiology, Editorial board
• Neurology, Ad-hoc reviewer
• Society of Neurocritical Care, Board of Directors
• Society of NeuroCritical Care, Finance Secretary, 1/1/05 - 1/1/07
• Tzu Chi Medical Journal, International Editor