Malcolm V. Brock, MD

Professional Titles

• Director of Clinical and Translational Research in Thoracic Surgery

Primary Academic Title

Professor of Surgery

Background

Centers and Institutes

• Esophageal Cancer Program
• Lung Cancer Program
• Sidney Kimmel Comprehensive Cancer Center
• Sweat Disorders, Center for

Videos

• Meet Our Expert - Dr. Malcolm Brock

• Microwave Thermolysis for Excessive Sweating

• Battling Cancer Using Epigenetics | Science: Out of the Box

Recent News Articles and Media Coverage

• Do You Suffer From Excessive Sweating?

Additional Academic Titles

Professor of Oncology

Research Interests

Biomarkers as predictors of cancer detection, Epigenetics research for cancer treatment, Hyperhidrosis, Prognosis and Chemotherapy Sensitivity, Translating Basic Research into the Clinic, Tumor Biology of Lung and Esophageal Cancer

Research Summary

Dr. Brock's research has focused primarily on developing and clinically applying molecular biomarkers, namely DNA methylation, to facilitate the early detection, accurate prognosis and specific chemosensitivity of lung and esophageal cancers. Current projects include using DNA methylation as a more accurate molecular indicator of lymph micrometases in a large cohort of lung cancer patients and as a means of predicting sensitivity of esophageal cancer to neoadjuvant chemotherapy based on endoscopic biopsy samples. Dr. Brock actively collaborates with Drs. Stephen Baylin and James Herman in the Division of Tumor Biology in the Cancer Center. Recently, Dr. Brock has received NIH funding to investigate the rising incidence of lung cancer in HIV patients and has begun both a clinical study and a tumor-profiling project in this regard. Finally, the Brock laboratory has developed large relational databases of lung and esophageal patients with matching biological samples to validate biomarker discovery.

PubMed

https://www.ncbi.nlm.nih.gov/pubmed/?term=Brock%2C+Malcolm%5BAuthor%5D

Selected Publications

• Brock, M.V.; Hooker, C.M.; Engels, E.A.; Moore, R.D.; Gillison, M.L.; Alberg, A.J.; Keruly, J.C.; Yang, S.C.; Heitmiller, R.F.; Baylin, S.B.; Herman, J.G.; Brahmer, J.R. Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient care. J Acquir Immune Defic Syndr. 2006 Sep;43(1):47-55.
  
  Chan, C.W.; Crafton, E.; Fan, H.N.; Flook, J.; Yoshimura, K.; Skarica, M.; Brockstedt, D.; Dubensky, T.W.; Stins, M.F.; Lanier, L.L.; Pardoll, D.M.; Housseau, F. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat Med. 2006 Feb;12(2):207-213.
  
  Engels, E.A.; Brock, M.V.; Chen, J.; Hooker, C.M.; Gillison, M.; Moore, R.D. Elevated incidence of lung cancer among HIV-infected individuals. J Clin Oncol. 2006 Mar 20;24(9):1383-1388.
  
  Gallia, G.L.; Rand, V.; Siu, I.M.; Eberhart, C.G.; James, C.D.; Marie, S.K.; Oba-Shinjo, S.M.; Carlotti, C.G.; Caballero, O.L.; Simpson, A.J.; Brock, M.V.; Massion, P.P.; Carson, B.S., Sr.; Riggins, G.J. PIK3CA gene mutations in pediatric and adult glioblastoma multiforme. Mol Cancer Res. 2006 Oct;4(10):709-714.
  
  Guo, M.; House, M.G.; Akiyama, Y.; Qi, Y.; Capagna, D.; Harmon, J.; Baylin, S.B.; Brock, M.V.; Herman, J.G. Hypermethylation of the GATA gene family in esophageal cancer. Int J Cancer. 2006 Nov 1;119(9):2078-2083.
  
  Guo, M.; Ren, J.; House, M.G.; Qi, Y.; Brock, M.V.; Herman, J.G. Accumulation of promoter methylation suggests epigenetic progression in squamous cell carcinoma of the esophagus. Clin Cancer Res. 2006 Aug 1;12(15):4515-4522.
  
  Machida, E.O.; Brock, M.V.; Hooker, C.M.; Nakayama, J.; Ishida, A.; Amano, J.; Picchi, M.A.; Belinsky, S.A.; Herman, J.G.; Taniguchi, S.; Baylin, S.B. Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer. Cancer Res. 2006 Jun 15;66(12):6210-6218.
  
  Montgomery, E.; Mamelak, A.J.; Gibson, M.; Maitra, A.; Sheikh, S.; Amr, S.S.; Yang, S.; Brock, M.; Forastiere, A.; Zhang, S.; Murphy, K.M.; Berg, K.D. Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesions. Appl Immunohistochem Mol Morphol. 2006 Mar;14(1):24-30.
  
  Singh, A.; Misra, V.; Thimmulappa, R.K.; Lee, H.; Ames, S.; Hoque, M.O.; Herman, J.G.; Baylin, S.B.; Sidransky, D.; Gabrielson, E.; Brock, M.V.; Biswal, S. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med. 2006 Oct;3(10):e420.
  
  Weiss, E.S.; Doty, J.; Brock, M.V.; Halvorson, L.; Yang, S.C. A case of ectopic parathyroid hormone production by a pulmonary neoplasm. J Thorac Cardiovasc Surg. 2006 Apr;131(4):923-924.
  
  Yoshimura, K.; Jain, A.; Allen, H.E.; Laird, L.S.; Chia, C.Y.; Ravi, S.; Brockstedt, D.G.; Giedlin, M.A.; Bahjat, K.S.; Leong, M.L.; Slansky, J.E.; Cook, D.N.; Dubensky, T.W.; Pardoll, D.M.; Schulick, R.D. Selective targeting of antitumor immune responses with engineered live-attenuated Listeria monocytogenes. Cancer Res. 2006 Jan 15;66(2):1096-1104.
  
  Brock, M.V.; Herman, J.G.; Baylin, S.B. Cancer as a manifestation of aberrant chromatin structure. Cancer J. 2007 Jan-Feb;13(1):3-8.
  
  Engel, L.S.; Laden, F.; Andersen, A.; Strickland, P.T.; Blair, A.; Needham, L.L.; Barr, D.B.; Wolff, M.S.; Helzlsouer, K.; Hunter, D.J.; Lan, Q.; Cantor, K.P.; Comstock, G.W.; Brock, J.W.; Bush, D.; Hoover, R.N.; Rothman, N. Polychlorinated biphenyl levels in peripheral blood and non-Hodgkin's lymphoma: a report from three cohorts. Cancer Res. 2007 Jun 1;67(11):5545-5552.
  
  Gibbons, M.C.; Brock, M.; Alberg, A.J.; Glass, T.; LaVeist, T.A.; Baylin, S.; Levine, D.; Fox, C.E. The sociobiologic integrative model (SBIM): enhancing the integration of sociobehavioral, environmental, and biomolecular knowledge in urban health and disparities research. J Urban Health. 2007 Mar;84(2):198-211.
  
  Goldberg, M.V.; Maris, C.H.; Hipkiss, E.L.; Flies, A.S.; Zhen, L.; Tuder, R.M.; Grosso, J.F.; Harris, T.J.; Getnet, D.; Whartenby, K.A.; Brockstedt, D.G.; Dubensky, T.W., Jr.; Chen, L.; Pardoll, D.M.; Drake, C.G. Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood. 2007 Jul 1;110(1):186-192.
  
  Guo, M.; House, M.G.; Suzuki, H.; Ye, Y.; Brock, M.V.; Lu, F.; Liu, Z.; Rustgi, A.K.; Herman, J.G. Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer. Int J Cancer. 2007 Sep 15;121(6):1219-1226.
  
  Liu, C.; Zhou, S.; Begum, S.; Sidransky, D.; Westra, W.H.; Brock, M.; Califano, J.A. Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer. Lung Cancer. 2007 Mar;55(3):303-311.
  
  Madar, I.; Bencherif, B.; Lever, J.; Heitmiller, R.F.; Yang, S.C.; Brock, M.; Brahmer, J.; Ravert, H.; Dannals, R.; Frost, J.J. Imaging delta- and mu-opioid receptors by PET in lung carcinoma patients. J Nucl Med. 2007 Feb;48(2):207-213.
  
  Sherwood, J.T.; Brock, M.V. Lung cancer: new surgical approaches. Respirology. 2007 May;12(3):326-332.
  
  Taube, J.M.; Askin, F.B.; Brock, M.V.; Westra, W. Impact of elastic staining on the staging of peripheral lung cancers. Am J Surg Pathol. 2007 Jun;31(6):953-956.
  
  Brock, M.V.; Hooker, C.M.; Ota-Machida, E.; Han, Y.; Guo, M.; Ames, S.; Glockner, S.; Piantadosi, S.; Gabrielson, E.; Pridham, G.; Pelosky, K.; Belinsky, S.A.; Yang, S.C.; Baylin, S.B.; Herman, J.G. DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med. 2008 Mar 13;358(11):1118-1128.
  
  Daniels, J.A.; Gibson, M.K.; Xu, L.; Sun, S.; Canto, M.I.; Heath, E.; Wang, J.; Brock, M.; Montgomery, E. Gastrointestinal tract epithelial changes associated with taxanes: marker of drug toxicity versus effect. Am J Surg Pathol. 2008 Mar;32(3):473-477.
  
  Forastiere, A.A.; Ang, K.K.; Brizel, D.; Brockstein, B.E.; Burtness, B.A.; Cmelak, A.J.; Colevas, A.D.; Dunphy, F.; Eisele, D.W.; Goepfert, H.; Hicks, W.L., Jr.; Kies, M.S.; Lydiatt, W.M.; Maghami, E.; Martins, R.; McCaffrey, T.; Mittal, B.B.; Pfister, D.G.; Pinto, H.A.; Posner, M.R.; Ridge, J.A.; Samant, S.; Schuller, D.E.; Shah, J.P.; Spencer, S.; Trotti, A., 3rd; Weber, R.S.; Wolf, G.T.; Worden, F. Head and neck cancers. J Natl Compr Canc Netw. 2008 Aug;6(7):646-695.
  
  Guo, M.; Ren, J.; Brock, M.V.; Herman, J.G.; Carraway, H.E. Promoter methylation of HIN-1 in the progression to esophageal squamous cancer. Epigenetics. 2008 Nov;3(6):336-341.
  
  Kleinberg, L.R.; Brock, M.V.; Jagannath, S.B.; Forastiere, A.A. Cancer of the Esophagus. In: Abeloff, M.e.a., editor. 4th Edition ed, Clinical Oncology. New York, NY: Churchill-Livingstone; 2008.
  
  Meguid, R.A.; Brooke, B.S.; Chang, D.C.; Sherwood, J.T.; Brock, M.V.; Yang, S.C. Are surgical outcomes for lung cancer resections improved at teaching hospitals? Ann Thorac Surg. 2008 Mar;85(3):1015-1024; discussion 1024-1015.
  
  Argiris, A.; Buchanan, A.; Brockstein, B.; Kolesar, J.; Ghebremichael, M.; Pins, M.; Hahn, K.; Axelrod, R.; Forastiere, A. Docetaxel and irinotecan in recurrent or metastatic head and neck cancer: a phase 2 trial of the Eastern Cooperative Oncology Group. Cancer. 2009 Oct 1;115(19):4504-4513.
  
  Jiang, T.; Collins, B.J.; Jin, N.; Watkins, D.N.; Brock, M.V.; Matsui, W.; Nelkin, B.D.; Ball, D.W. Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer. Cancer Res. 2009 Feb 1;69(3):845-854.
  
  Meguid, R.A.; Hooker, C.M.; Taylor, J.T.; Kleinberg, L.R.; Cattaneo, S.M., 2nd; Sussman, M.S.; Yang, S.C.; Heitmiller, R.F.; Forastiere, A.A.; Brock, M.V. Recurrence after neoadjuvant chemoradiation and surgery for esophageal cancer: does the pattern of recurrence differ for patients with complete response and those with partial or no response? J Thorac Cardiovasc Surg. 2009 Dec;138(6):1309-1317.
  
  Meguid, R.A.; Weiss, E.S.; Chang, D.C.; Brock, M.V.; Yang, S.C. The effect of volume on esophageal cancer resections: what constitutes acceptable resection volumes for centers of excellence? J Thorac Cardiovasc Surg. 2009 Jan;137(1):23-29.
  
  Tjiang, T.; B.J., C.; Jin, N.; Brock, M.V.; Watkins, D.N.; Matsui, W.; Nelkin, B.D.; Ball, D.W. ASCL1 regulates CD133 and tumor-initiating capacity of SCLC. Cancer Research. 2009 (In Press).
  
  Bailey, V.J.; Keeley, B.P.; Zhang, Y.; Ho, Y.P.; Easwaran, H.; Brock, M.V.; Pelosky, K.L.; Carraway, H.E.; Baylin, S.B.; Herman, J.G.; Wang, T.H. Enzymatic incorporation of multiple dyes for increased sensitivity in QD-FRET sensing for DNA methylation detection. Chembiochem. 2010 Jan 4;11(1):71-74.
  
  Bailey, V.J.; Zhang, Y.; Keeley, B.P.; Yin, C.; Pelosky, K.L.; Brock, M.; Baylin, S.B.; Herman, J.G.; Wang, T.H. Single-tube analysis of DNA methylation with silica superparamagnetic beads. Clin Chem. 2010 Jun;56(6):1022-1025.
  
  Bhattacharya, R.; Kowalski, J.; Larson, A.R.; Brock, M.; Alani, R.M. Id1 promotes tumor cell migration in nonsmall cell lung cancers. J Oncol. 2010;2010:856105.
  
  Brock, M.V.; Bouvet, M. Writing a successful NIH Mentored Career Development Grant (K award): hints for the junior faculty surgeon. Ann Surg. 2010 Jun;251(6):1013-1017
  
  Chiao, E.Y.; Dezube, B.J.; Krown, S.E.; Wachsman, W.; Brock, M.V.; Giordano, T.P.; Mitsuyasu, R.; Pantanowitz, L. Time for oncologists to opt in for routine opt-out HIV testing? JAMA. 2010 Jul 21;304(3):334-339
  
  Liu, K.J.; Brock, M.V.; Shih Ie, M.; Wang, T.H. Decoding circulating nucleic acids in human serum using microfluidic single molecule spectroscopy. J Am Chem Soc. 2010 Apr 28;132(16):5793-5798
  
  Meguid, R.A.; Hooker, C.M.; Harris, J.; Xu, L.; Westra, W.H.; Sherwood, J.T.; Sussman, M.; Cattaneo, S.M., 2nd; Shin, J.; Cox, S.; Christensen, J.; Prints, Y.; Yuan, N.; Zhang, J.; Yang, S.C.; Brock, M.V. Long-term survival outcomes by smoking status in surgical and nonsurgical patients with non-small cell lung cancer: comparing never smokers and current smokers. Chest. 2010 Sep;138(3):500-509.
  
  Tseng, E.E.; Brock, M.V.; Lange, M.S.; Troncoso, J.C.; Blue, M.E.; Lowenstein, C.J.; Johnston, M.V.; Baumgartner, W.A. Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest. Ann Thorac Surg. 2010 Feb;89(2):440-445