Paul Rothman, MD
- Johns Hopkins School of Medicine Faculty
Languages
- English
Gender
MaleAbout Paul Rothman
Primary Academic Title
Professor of Medicine
Background
Dr. Paul B. Rothman is a professor of medicine at the Johns Hopkins University School of Medicine. He holds a secondary appointment in the Department of Molecular Biology and Genetics.
A rheumatologist and molecular immunologist, Dr. Rothman served as vice president for medicine at The Johns Hopkins University, and as the Frances Watt Baker, M.D., and Lenox D. Baker Jr., M.D., Dean of the Medical Faculty and chief executive officer of Johns Hopkins Medicine from 2012–2022.
Dr. Rothman earned his medical degree (Alpha Omega Alpha) at Yale University School of Medicine. He completed both an internal medicine residency and a rheumatology fellowship at New York-Presbyterian/Columbia University Irving Medical Center, as well as a postdoctoral biochemistry fellowship at Columbia University College of Physicians and Surgeons.
He also holds a Bachelor of Science in biology (Phi Beta Kappa) from the Massachusetts Institute of Technology.
Dr. Rothman’s research focuses on the role of cytokines in the development of blood cells called leukocytes—the abnormal development of which can lead to leukemia—and in immune responses to asthma and allergies.
Before joining the Johns Hopkins faculty in 2011, Dr. Rothman served as dean of the University of Iowa Carver College of Medicine and leader of the university’s clinical practice plan. Prior to that, he served as professor and head of Iowa’s Department of Internal Medicine, with secondary appointments in the Department of Microbiology and the Department of Physiology and Biophysics.
On the faculty of the Columbia University College of Physicians and Surgeons from 1986 to 2004, Dr. Rothman was the founding chief of its Division of Pulmonary, Allergy and Critical Care Medicine. He later served as vice chair for research of the Department of Medicine.
Dr. Rothman’s awards include a James S. McDonnell Foundation Career Development Award, a Pfizer Scholars Award, a Pew Scholars Award, a Leukemia Society of America Scholar Award and the Pharmacia Allergy Research Foundation International Award.
He is an elected member of the American Association for the Advancement of Science, American College of Physicians, Council of the Association of American Physicians and American Society of Clinical Investigation.
Dr. Rothman is a member of the Merck board of directors and receives compensation in the form of income and stock. Dr. Rothman also is a member of the board of directors of the King Faisal Specialty Hospital, for which he receives compensation in the form of income. To submit concerns related to this arrangement, please contact: policy@jhmi.edu.
Dr. Rothman has served as a member of the National Institutes of Health Immunologic Sciences Study Section, the Israel Cancer Research Fund International Scientific Advisory Board, the American Academy of Allergy, Asthma and Immunology Grant Review Committee and the American Thoracic Society Asthma Immunology and Inflammation Program Committee.
Videos
Additional Academic Titles
Professor of Molecular Biology and Genetics
Research Interests
Cytokines, Immune responses to asthma and allergies, Leukocytes
Lab Website
Paul Rothman Lab - Lab Website
- Research in the Paul Rothman Lab has focused on cytokines. We've investigated the role these molecules play in the normal development of blood cells as well as the abnormal blood-cell development that leads to leukemia. We've also studied the function of cytokines in immune system responses to asthma and allergies.
Research Summary
Dr. Rothman’s research on cytokines (immune system molecules) focuses on their role in the development of blood cells called leukocytes. Abnormal development of these blood cells can lead to leukemia.
He also studies the role of cytokines in immune system responses to asthma and allergies.
Selected Publications
Gorman, J.V.,Starbeck-Miller, G.,Pham, N-L., Traver, G.L., Rothman, P.B., Harty, J.T., Colgan, J.D. Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection. J. Immunol. (2014) 192. 3133-3142
Kashiwada. M., D. M. Levy, L. McKeag, K. Murray, A. J. Schröder, S. M. Canfield, and P. B. Rothman. Interleukin-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching. (2010) PNAS, USA. 107:821-826
Shapiro, S.D., and P. Rothman. How Academic Health Systems Can Move Forward Once COVID-19 Wanes. (2020) JAMA 323:23 2377-2378
Sojka, D.K., Plougastel-Douglas, B., Yang, L., Pak-Wittel, M. A., Artyomov, M.N., Yulia Ivanova, Y., Zhong , C., Elliot, J.M., Rothman, P.B., Yu, J., Riley, J.K., Zhu , J., Tian, Z., and W. M. Yokoyama. Tissue-Resident Natural Killer Cells Are Cell Lineages Distinct From Thymic and Conventional Splenic Natural Killer Cells. eLife (2014) Vol 3., UNSP e01659. April 8
Verena Staedtke, Ren-Yuan Bai, , Kibem Kim, Martin Darvas, Marco L. Davila, Gregory J. Riggins, Paul B. Rothman, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein and Shibin Zhou. Disruption of self-amplifying catecholamine loop reduces cytokine release syndrome. Nature (2018) 564:273-277
Yu, X. Rollins, D., Ruhn, K.A., Stubblefield, J.J., Green, C.B., Kashiwada, M., Rothman, P.B., Takahashi, J.S., and L. V. Hooper. NFIL3 suppresses Rorγ t transcription and links intestinal Th17 cell differentiation to the circadian clock network. Science (2013) 342:727-730
Ziegelstein,, R.C., .C. G. Prober, L. B. Minor, G. Q. Daley, P. B. Rothman, and E. M. Hundert, Is There Merit in Merit Aid. (2017). NEJM., 377:2415-2417
Honors
- President, Association of American Physicians, 1/1/14
- Fellow, American Association for the Advancement of Science, 1/1/08
- Fellow, American College of Physicians, 1/1/05
- Donald D. Dorfman Research Award for Outstanding Published Basic Science Paper, University of Iowa Cancer Center, 1/1/05
- International Award, Pharmacia Allergy Research Foundation, 1/1/97
- Scholar Award, Leukemia Society of America, 1/1/95
- Fellowship Award, Pharmacia Allergy Research Foundation, 1/1/94
- Pew Scholarship in the Biomedical Sciences, The Pew Charitable Trust, 1/1/92
- Scholars Award for New Faculty, Pfizer, 1/1/91
- Career Development Award in Molecular Medicine and Oncology, James S. McDonnell Foundation, 1/1/89
- Physician Scientist Award, National Institutes of Health, 1/1/86
Additional Training
- Residency: Internal Medicine; New York-Presbyterian/Columbia University Irving Medical Center (1986)
- Fellowship: Biochemistry; Columbia University College of Physicians and Surgeons (1990)
- Fellowship: Rheumatology; New York-Presbyterian/Columbia University Irving Medical Center (1989)
- Board Certification: American Board of Internal Medicine (Internal Medicine) (1988)