Jennifer Pardo, MD

Primary Academic Title

Assistant Professor of Pediatrics

Background

Centers and Institutes

• Blalock-Taussig-Thomas Pediatric and Congenital Heart
• Inherited Heart Disease, Center for
• Johns Hopkins Children's Center
• McKusick-Nathans Institute of Genetic Medicine

Research Interests

Aortic aneurysm, Connective Tissue Disorders

Research Summary

Dr. Habashi researches connective tissue disorders, particularly Marfan syndrome. She performed the initial studies demonstrating the effectiveness of losartan in mouse models of Marfan. She is currently evaluating the utility of additional medications for the treatment of this disorder.

PubMed

http://www.ncbi.nlm.nih.gov/pubmed?term=Habashi,%20Jennifer%5BFull%20Author%20Name%5D&cmd=DetailsSearch

Selected Publications

• Gallo EM, Loch DC, Habashi JP, Calderon JF, Chen Y, Bedja D, van Erp C, Gerber EE, Parker SJ, Sauls K, Judge DP, Cooke SK, Lindsay ME, Rouf R, Myers L, ap Rhys CM, Kent KC, Norris RA, Huso DL, Dietz HC. “Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.” J Clin Invest. 2014 Jan;124(1):448-60. doi: 10.1172/JCI69666. Epub 2013 Dec 20.

• Habashi JP, Doyle JJ, Holm TM, Aziz H, Schoenhoff F, Bedja D, Chen Y, Modiri AN, Judge DP, Dietz HC. “Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism.” Science. 2011 Apr 15;332(6027):361-5. doi: 10.1126/science.1192152.

• Holm TM, Habashi JP, Doyle JJ, Bedja D, Chen Y, van Erp C, Lindsay ME, Kim D, Schoenhoff F, Cohn RD, Loeys BL, Thomas CJ, Patnaik S, Marugan JJ, Judge DP, Dietz HC. “Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice.” Science. 2011 Apr 15;332(6027):358-61. doi: 10.1126/science.1192149.

• Judge DP, Rouf R, Habashi J, Dietz HC. “Mitral valve disease in Marfan syndrome and related disorders.” J Cardiovasc Transl Res. 2011 Dec;4(6):741-7. doi: 10.1007/s12265-011-9314-y. Epub 2011 Aug 25. Review.

• Liu D, Wang CJ, Judge DP, Halushka MK, Ni J, Habashi JP, Moslehi J, Bedja D, Gabrielson KL, Xu H, Qian F, Huso D, Dietz HC, Germino GG, Watnick T. “A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease.” J Am Soc Nephrol. 2014 Jan;25(1):81-91. doi: 10.1681/ASN.2012050486. Epub 2013 Sep 26.

Honors

• Accelerated Translational Incubator Pilot (ATIP) Program Award, Johns Hopkins Institute for Clinical and Translational Research,, 1/1/14
• Morford Family Grant, National Marfan Foundation, 1/1/12
• Francis F. Schwentker Award for Excellence in Research by Pediatrics House Staff and Clinic Fellows, The Johns Hopkins University School of Medicine, 5/1/06
• Outstanding Investigator Award, Children's Hospital of Philadelphia Pediatric Cardiology Meeting, 1/1/06
• Young Investigator Award, National Marfan Symposium, 1/1/05
• Postdoctoral Presentation Award, American Society of Human Genetics, 1/1/05
• Outstanding Research Award, American Heart Association Scientific Sessions, 1/1/05
• Travel Grant, Women in Cardiology, 1/1/04