Ray DePaulo Jr., MD
Psychiatry
- Johns Hopkins School of Medicine Faculty
About Ray DePaulo Jr.
Physician’s Office Phone
410-955-6819
Physician’s Office Fax
410-502-3755
Professional Titles
- University Distinguished Service Professor
- Co-Director of the Mood Disorder Center
Primary Academic Title
Professor of Psychiatry and Behavioral Sciences
Background
Dr. Ray DePaulo is a University Distinguished Service Professor and Co-Director of the Mood Disorder Center in the Department of Psychiatry and Behavioral Sciences at Johns Hopkins Medicine. He has been an active clinician, teacher, and researcher throughout his 46 years with the Hopkins faculty. He founded the Hopkins Affective or Mood Disorders Clinic in 1977 and grew it into a multifaceted program of patient care, teaching and research that is a centerpiece in today’s Johns Hopkins Mood Disorders Center.
Dr. DePaulo’s clinical and research interests focus on clinical assessment and the causes and treatments of bipolar disorders and depression. Under his leadership, the Hopkins Mood Disorders research group led several early genetic studies of bipolar disorder and unipolar depression. He has authored over 180 peer-reviewed scientific articles and mentored outstanding clinicians, scientists and leaders in the research of bipolar disorder and depression.
He has partnered with Dr. Kay Jamison in research, education and advocacy efforts for patients and families. and together they founded (2008) and now lead the Hopkins Mood Disorders Center. Dr. DePaulo was the Henry Phipps Professor and Director of the Department of Psychiatry and Behavioral Sciences at Johns Hopkins Medicine and Psychiatrist in Chief at the Johns Hopkins Hospital from 2002 until 2016. From 2016 until 2022 he was the President of the National Network of Depression Centers (NNDC.org).
Today, Dr. DePaulo remains an active clinician and an enthusiastic teacher and mentor of students, residents, fellows and junior faculty. He serves on many foundation boards and scientific advisory groups related to mood disorders including the Depression & Bipolar Support Alliance and Project Healthy Minds. Dr. DePaulo has authored two books on depressive illnesses for patients and families. He has won several national & international awards for clinical leadership, teaching, and research.
Centers and Institutes
Research Interests
Bipolar Disorders, Depression
Selected Publications
Nwulia EA, Miao K, Zandi PP, Mackinnon DF, DePaulo JR, McInnis MG. Genome-wide scan of bipolar II disorder. Bipolar Disord. 6: 580-8, 2007.
Verma R, Cutler DJ, Holmans P, Knowles JA, Crowe RR, Scheftner WA, Weissman MM, DePaulo JR Jr, Levinson DF, Potash JB. Investigating the role of p11 (S100A10) sequence variation in susceptibility to major depression. American Journal of Medical Genetics (Neuropsychiatric Genetics) 144:1079-82, 2007.
Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR Jr, Feinberg AP, McMahon FJ; NIMH Genetics Initiative Bipolar Disorder Consortium. Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1. American Journal of Medical Genetics (Neuropsychiatric Genetics). 147: 59-67, 2008.
Willour VL, Chen H, Toolan J, Belmonte P, Cutler DJ, Goes FS, Zandi PP, Lee RS, Mackinnon DF, Mondimore FM, Schweizer B, Depaulo JR Jr, Gershon ES, McMahon FJ, Potash JB. Family-based association of FKBP5 in bipolar disorder. Mol Psychiatry. 14: 261268, 2009.
Payne JL, MacKinnon DF, Mondimore FM, McInnis MG, Schweizer B, Zamoiski RB, McMahon FJ, Nurnberger JI Jr, Rice JP, Scheftner W, Coryell W, Berrettini WH, Kelsoe JR, Byerley W, Gershon ES, DePaulo JR, Potash JB. Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees. Bipolar Disord. 10: 38-44,2008.
Verma R, Holmans P, Knowles JA, Grover D, Evgrafov OV, Crowe RR, Scheftner WA, Weissman MM, Depaulo JR Jr, Potash JB, Levinson DF. Linkage Disequilibrium Mapping of a Chromosome 15q25-26 Major Depression Linkage Region and Sequencing of NTRK3. Biological Psychiatry. 63:1185-9, 2008.
Langlieb AM, DePaulo JR, Etiology of depression and implications on work environment. Journal of Occupational Environmental Medicine. 391-5, 2008.
Barton CD, DePaulo JR, The unrecognized costs of delirium. Nature Clinical Practice Neurology. 4:233, 2008. [Editorial]
Zandi PP, Belmonte PL, Willour VL, Goes FS, Badner JA, Simpson SG, Gershon ES, McMahon FJ, DePaulo JR
Potash JB; Association study of Wnt signaling pathway genes in bipolar disorder. Bipolar Disorder Phenome Group; National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium. Archives of General Psychiatry. 65: 785-93, 2008.
Nwulia EA, Zandi PP, McInnis MG, DePaulo JR, MacKinnon DF. Rapid switching of mood in families with familial bipolar disorder. Bipolar Disord. 10: 597-606, 2008.
Payne JL, Klein SR, Zamoiski RB, Zandi PP, Bienvenu OJ, Mackinnon DF, Mondimore FM, Schweizer B, Swartz KL; Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees. NIMH Genetics Initiative Bipolar Disorder Consortium, Crowe RP, Scheftner WA, Weissman MM, Levinson DF, DePaulo JR, Potash JB. Archives of Women's Mental Health.12: 27-34, 2009
Honors
- Research Award, American Foundation for Suicide Prevention, 1/1/07
- Samuel Guze Lecture, Washington University, 1/1/02
- SELO Prize, for outstanding research on depression, National Association for Research in Schizophrenia and Depression (NARSAD), 1/1/96
- Harriett and Milton Parker Lecture in Psychiatric Genetics, Ohio State University, 1/1/95
- Public Education Award, The 1992 NIMH - D/ART, 1/1/92
- Alpha Omega Alpha, (elected alumnus chapter), 1/1/91
- Outstanding New Research, National Depressive and Manic Depressive Association, 1/1/89
Memberships
- American Foundation for Suicide Prevention
- Depression and Bipolar Support Association
- National Association for Research in Schizophrenia and Depression
Expertise
Education
Johns Hopkins University School of Medicine
Residency, Psychiatry, 1977Johns Hopkins Bayview Medical Center
Residency, Psychiatry, 1974Johns Hopkins University School of Medicine
Medical Education, MD, 1972Board Certifications
Psychiatry
American Board of Psychiatry and Neurology, 1977Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)