Howard M. Lederman, MD, PhD

Professional Titles

• Director, Immunodeficiency Clinic
• Director, Ataxia-Telangiectasia Clinical Center
• Director, Pediatric Immunology Laboratory

Primary Academic Title

Professor of Pediatrics

Background

Centers and Institutes

• Ataxia Telangiectasia Clinical Center
• Johns Hopkins Children's Center

CV

http://www.hopkinsmedicine.org/johns-hopkins-childrens-center/_documents/_cvs/lederman_howard_cv.pdf

Clinical Trial Keywords

Immunoglobulin; Gamma globulin; Ataxia- Telangiectasia

Clinical Trials Summary

Cell-Based Approaches For Modeling and Treating Ataxia-Telangiectasia

Additional Academic Titles

Joint Appointment in Medicine

Research Interests

Antibody deficiency, Ataxia-Telangiectasia, Chronic granulomatous disease and other disorders of phagocytes, Common variable immunodeficiency, Complement deficiency, DiGeorge syndrome, Hyper-IgE syndrome, Hyper-IgM syndrome, Hypogammaglobulinemia, IgA deficiency, IgM deficiency, Immunoglobulin therapy, IVIG, Primary Immunodeficiency Diseases, Severe combined immunodeficiency, Wiskott-Aldrich syndrome, X-linked agammaglobulinemia

Research Summary

Dr. Lederman’s current research laboratory and clinical research focuses on better understanding and treating patients with ataxia-telangiectasia, a devastating neurological disorder for which there is no cure.

Selected Publications

• Alterman N, Fattal-Valevski A, Moyal L, Crawford TO, Lederman HM, Ziv Y, and Shiloh Y. “Ataxia-Telangiectasia: Mild neurological presentation despite null ATM mutation and severe cellular phenotype.” Am J Med Genet A.  2007 Aug 15;143A(16):1827-34.

• Daniels JA, Maitra A, Lederman HM, and Montgomery E. “Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): A clinicopathologic study and review.” Am J Surg Pathol.  2007 Dec;31(12):1800-12. 

• Lin, DDM, Crawford TO, Lederman HM, Barker PB. “Proton MR Spectroscopic Imaging in Ataxia-Telangiectasia.” Neuropediatrics.  2006 Aug;37(4):241-6.

• McGrath-Morrow S, Lefton-Greif M, Rosquist K, Crawford T, Kelly A, Zeitlin P, Carson K , Lederman HM. “Pulmonary function in adolescents with ataxia-telangiectasia.” Pediatr Pulmonol. 2008 Jan;43(1):59-66.

• Shreffler WG, Visness CM, Burger M, Cruikshank WW, Lederman HM, de la Morena M, Grindle K, Calatroni A, Sampson HA and Gern JE. “Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study.” BMC Immunol. 2006 Dec 12;7:29.

Memberships

• American Association of Immunologists
• American Society for Microbiology
• Clinical Immunology Society
• Infectious Diseases Society of America
• Society for Pediatric Research