What is cystic fibrosis liver disease?

Liver disease associated with cystic fibrosis (CF) has been increasingly diagnosed during recent years, most likely due to the combined effect of systematic hepatic assessment and reduced death from extrahepatic causes of CF patients. Although the natural history of CF-associated liver disease suggests a benign and protracted course in most cases, it is considered a major complication of CF, which may limit survival and quality of life.