Brian Ladle, MD, PhD

Primary Academic Title

Assistant Professor of Oncology

Background

Centers and Institutes

Sidney Kimmel Comprehensive Cancer Center

Clinical Trials Summary

Nivolumab or Nivolumab and Azacitidine in Patients With Recurrent, Resectable Osteosarcoma

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Additional Academic Titles

Assistant Professor of Pediatrics

Research Interests

Immunotherapy, Pediatric sarcomas, Translational immunology

Research Summary

Dr. Ladle is a practicing pediatric oncologist and translational immunology researcher who has the goal of developing novel immunotherapies for the treatment of pediatric malignancies. His research seeks to understand mechanisms of immune tolerance in pediatric sarcomas and developing successful combination immunotherapies that will successfully treat sarcoma patients. He is working on translational projects combining immunotherapy with chemotherapy, epigenetic modifying agents and innate immune system adjuvants. Dr. Ladle has extensive expertise in immunology techniques – including both mouse and in vitro cell culture, multi-color flow cytometry and molecular techniques.

Selected Publications

• A.M. Ercolini and B.H. Ladle (co-first authorship), E.A. Manning, L. Pfannenstiel, T.D. Armstrong, J.P.H. Machiels, J.G. Bieler, L.A. Emens, R.T. Reilly, E.M. Jaffee. “Recruitment of latent pools of high avidity CD8+ T cells to the anti-tumor immune response.” The Journal of Experimental Medicine. 2005 May 16;201(10):1591-602.

• D.T. Le and B.H. Ladle (co-first authorship), T. Lee, V. Weiss, X. Yao, A. Leubner, T.D. Armstrong, E.M. Jaffee. “CD8+ Foxp3+ tumor infiltrating lymphocytes accumulate in the context of an effective anti-tumor response.” International Journal of Cancer. 2011 Aug 1;129(3):636-47.

• R.M. Thomas, C.J. Gamper, B.H. Ladle, J.D. Powell, A.D. Wells. “De novo DNA methylation is required to restrict T helper lineage plasticity.” Journal of Biological Chemistry. 2012 Jun 29;287(27):22900-9

• S. Murata, B.H. Ladle, P.S. Kim, E.R. Lutz, M.E. Wolpoe, S.E. Ivie, H.M. Smith, T.D. Armstrong, L.A. Emens, E.M. Jaffee, R.T. Reilly. “OX40 Costimulation Synergizes with GM-CSF Whole-cell Vaccination to Overcome Established CD8+ T cell Tolerance to an Endogenous Tumor Antigen.” The Journal of Immunology. 2006 Jan. 15; 176(2):974-83.

Courses & Syllabi

Graduate Immunology Course, Lecturer, Johns Hopkins University School of Medicine, 1/1/18

Honors

• $1000 Presentation Award, Immuno-Oncology Young Investigator's Forum, 1/1/15
• John G. Rangos, Sr. Medal of Honor in Creative Thinking, 1/1/12
• Optimist International Research Fellow, Sidney Kimmel Comprehensive Cancer Center, 1/1/11
• Blackfan Research Award, Cincinnati Children's Hospital Medical Center, 1/1/10
• Turock Young Scientist Award, Johns Hopkins Institute of Basic Biomedical Sciences, 1/1/03

Memberships

• American Association for Cancer Research
• American Society for Pediatric Hematology/Oncology
• Children's Oncology Group
• American Society of Clinical Oncology

Professional Activities

• Member, Protocol Committee, National Pediatric Cancer Foundation, 2018