Andrew P. Lane, MD

Professional Titles

• Director, Johns Hopkins Sinus Center

Primary Academic Title

Professor of Otolaryngology-Head and Neck Surgery

Background

Centers and Institutes

Sinus Center

Clinical Trial Keywords

Chronic sinusitis with polyps; Cerebrospinal fluid leaks

Videos

• Meet our Experts - Dr. Andrew Lane

Recent News Articles and Media Coverage

• Stuffy Noses Are Miserable. These Nasal Congestion Treatments Actually Work, Scientific American 12/1/2023

Research Interests

Chronic sinusitis, Endoscopic orbital surgery, Innate immunity of the nose and sinuses, Inverted papilloma, Nasal polyps, olfactory loss due to chronic sinusitis, Underlying mechanisms of chronic sinusitis

Lab Website

Andrew Lane Lab - Lab Website

• The Lane laboratory is focused on understanding molecular mechanisms underlying chronic rhinosinusitis, particularly the pathogenesis of nasal polyps, as well as inflammation on the olfactory epithelium. Diverse techniques in molecular biology, immunology, and physiology are utilized to study epithelial cell innate immunity, olfactory loss, and response to viral infection. Ongoing work explores how epithelial cells of the sinuses and olfactory mucosa participate in the immune response and contribute to chronic inflammation. The lab creates and employs transgenic mouse models of chronic nasal/sinus inflammation to support research in this area. Collaborations are in place with the School of Public Health to explore mechanisms of anti-viral immunity in influenza and COVID-19.

PubMed

http://www.ncbi.nlm.nih.gov/pubmed/?term=Andrew+P+Lane

Selected Publications

• Chapter 12: Surgery for sinonasal disease. Higgins TS, Lane AP. Am J Rhinol Allergy. 2013 May-Jun;27 Suppl 1:S42-4. doi: 10.2500/ajra.2013.27.3897

• Endoscopic resection of esthesioneuroblastoma. Gallia GL, Reh DD, Lane AP, Higgins TS, Koch W, Ishii M. J Clin Neurosci. 2012 Nov;19(11):1478-82. doi: 10.1016/j.jocn.2012.03.011. Epub 2012 Sep 18

• Medical therapy reduces microbiota diversity and evenness in surgically recalcitrant chronic rhinosinusitis. Liu CM, Soldanova K, Nordstrom L, Dwan MG, Moss OL, Contente-Cuomo TL, Keim P, Price LB, Lane AP. Int Forum Allergy Rhinol. 2013 Jul 10. doi: 10.1002/alr.21195. [Epub ahead of print]

• Regulation of inflammation-associated olfactory neuronal death and regeneration by the type II tumor necrosis factor receptor. Pozharskaya T, Liang J, Lane AP. Int Forum Allergy Rhinol. 2013 Jun 3. doi: 10.1002/alr.21187. [Epub ahead of print]

• Sinonasal epithelial cell expression of Toll-like receptor 9 is elevated in cystic fibrosis-associated chronic rhinosinusitis. Melvin TA, Lane AP, Nguyen MT, Lin SY. Am J Rhinol Allergy. 2013 Jan;27(1):30-3. doi: 10.2500/ajra.2013.27.3834

• Sinonasal epithelial cells synthesize active vitamin D, augmenting host innate immune function. Sultan B, Ramanathan M Jr, Lee J, May L, Lane AP. Int Forum Allergy Rhinol. 2013 Jan;3(1):26-30. doi: 10.1002/alr.21087. Epub 2012 Oct 4

• Spontaneous eosinophilic nasal inflammation in a genetically-mutant mouse: comparative study with an allergic inflammation model. Cho SH, Oh SY, Zhu Z, Lee J, Lane AP. PLoS One. 2012;7(4):e35114. doi: 10.1371/journal.pone.0035114. Epub 2012 Apr 11

• Topical Drug Delivery for Chronic Rhinosinusitis.Liang J, Lane AP. Curr Otorhinolaryngol Rep. 2013 Mar 1;1(1):51-60. Epub 2012 Dec 27

Honors

• Earleen Elkins research award, American Academy of Otolaryngology Head and Neck Surgery Foundation
• GlaxoSmithKline research award, American Academy of Otolaryngology Head and Neck Surgery Foundation
• Passano Foundation Clinician Scientist Award, Passano Foundation
• Edmund Prince Fowler Award, Triological Society, 1/1/09
• American Rhinologic Society Research Awards, American Rhinologic Society, 1/1/08
• Maurice H. Cottle Award for Research in Rhinology, 1/1/07
• American Rhinologic Society Research Awards, American Rhinologic Society, 1/1/05

Memberships

• American Academy of Otolaryngology - Head and Neck Surgery
• American Rhinologic Society